A5049762011- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Economic and Financial Impacts of Cancer
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Cutaneous Melanoma Detection and Management
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Circular RNAs in diseases
- Multiple and Secondary Primary Cancers
- Uterine Myomas and Treatments
- Palliative Care and End-of-Life Issues
- Bioinformatics and Genomic Networks
- Global Cancer Incidence and Screening
Wayne State University
2020-2025
The Barbara Ann Karmanos Cancer Institute
2020-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2024
The Ohio State University
2016-2024
The Ohio State University Wexner Medical Center
2016-2024
Kurume University
2024
Caris Life Sciences (United States)
2023
USA Mitchell Cancer Institute
2023
University of South Alabama
2023
Washington University in St. Louis
2023
STAT3 is over-expressed in endometrial cancer, and diabetes a risk factor for the development of type 1 cancer. We therefore investigated whether glucose concentrations influence expression such might be inhibited by metformin.In Ishikawa (grade 1) cancer cells subjected to media with low, normal, or high glucose, its target proteins was evaluated real-time quantitative PCR (qPCR). were treated metformin assessed cell proliferation, survival, migration, ubiquitin assays, as well Western blot...
Vulvar squamous cell cancer (VSC) accounts for 90% of vulvar cancers. Next-generation sequencing studies VSC imply human papillomavirus (HPV) and p53 status play separate roles in carcinogenesis prognosis. We sought to describe the genomic landscape analyze immunologic profiles with respect HPV status. A total 443 tumors underwent tumor profiling. was performed on DNA isolated from formalin-fixed paraffin-embedded samples. PD-L1, microsatellite instability were tested by fragment analysis,...
PURPOSE The new CAP guideline published in August 2022 recommends using immunohistochemistry (IHC) to test for mismatch repair defects gastroesophageal (GE), small bowel (SB), or endometrial carcinoma (EC) cancers over next-generation sequencing assessment of microsatellite instability (NGS-MSI) immune checkpoint inhibitor (ICI) therapy eligibility and states there is a preference use IHC NGS-MSI colorectal (CRC). METHODS We assessed the concordance IHC-MMR from very large cohort across...
Abstract The initial molecular events that lead to malignant transformation of the fimbria fallopian tube (FT) through high-grade serous ovarian carcinoma (HGSC) remain poorly understood. In this study, we report increased expression signal transducer and activator transcription 3 (pSTAT3 Tyr705) suppression or loss protein inhibitor activated STAT3 (PIAS3) in FT likely drive HGSC. We evaluated human tissues-benign normal FT, tubal-peritoneal junction (TPJ), p53 signature tissue, tubal...
Abstract Background Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with overall incidence increasing, particularly high‐grade disease. There sparse information regarding quality of life (QOL) EC survivors a focus on grade Methods A total 259 women diagnosed between 2016 and 2020 were identified via Metropolitan Detroit Cancer Surveillance System consented to enroll Research Survivors cohort study (if African American, n = 138) or completed baseline...
► Ovarian small-cell carcinoma of the hypercalcemic type is a rare neoplasm with no standard treatment. The chemotherapy regimen including vinblastine, cisplatin, cyclophosphamide, bleomycin, doxorubicin and etoposide (VPCBAE) has limited toxicities was effective in 3 patients described this case report.
Uveal melanoma (UM) is a major intraocular cancer that molecularly distinct from cutaneous melanoma. Approximately half of patients with UM eventually develop metastasis. The prognosis metastatic poor, median overall survival (OS) less than year. In this study, we sought to identify microRNAs (miRNAs) associated metastasis and OS in UM. We analyzed the miRNA expression clinical outcomes data Cancer Genome Atlas (TCGA) dataset for Differential analyses were conducted each respect...
PURPOSE Evaluation by a gynecologic oncologist (GO) is associated with improved clinical outcomes for patients cancers, yet little known about health care factors that influence patients' referrals to GO. METHODS Medical records of 50 consecutive new seen in GO clinics at each six referral centers across the United States were reviewed. Patient and disease characteristics collected along indication, evaluation dates, diagnostic procedures, provider specialties, zone improvement plan (ZIP)...
Abstract Endometrial cancer (EC) is the leading gynecologic malignancy in United States with obesity implicated 57% of cases. This research delves into molecular complexities extracellular vesicle (EV) secretion as carriers oncogenic protein expression and their involvement obesity-mediated EC. An understanding these mechanisms pivotal for unraveling pathways relevant to obesity-associated EC, thereby guiding development innovative prevention treatment strategies. Our investigation revealed...
Abstract Introduction: Endometrial cancer (EC) is the leading gynecologic malignancy in U.S., with obesity implicated 57% of cases. This study explores molecular workings oncogenic protein expression (TMEM205, STAT5, and FAS) their role regulating exosome secretion. Understanding these mechanisms crucial for unraveling pathways involved obesity-related EC, informing development innovative strategies prevention treatment. Methods: The isolated exosomes were quantified using nanoparticle...
4127 Background: HPV is an infectious cause of several malignancies. Neuroendocrine neoplasms (NEN) are highly heterogeneous, ranging from low-grade indolent tumors to high-grade clinically aggressive carcinomas. Aside cervical NENs, most have not traditionally been associated with HPV, but our initial studies uncovered a subset NENs that 16/18 positive. To identify actionable differences between HPV+ NEN and non-NENs, genomic transcriptomic landscapes were investigated. Methods: 101343...