A5013334776- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Diversity and Career in Medicine
- Uterine Myomas and Treatments
- Pelvic floor disorders treatments
- Neutropenia and Cancer Infections
- Clinical practice guidelines implementation
- Meta-analysis and systematic reviews
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Endometriosis Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Bacterial Identification and Susceptibility Testing
- scientometrics and bibliometrics research
- Cancer Risks and Factors
- Healthcare Systems and Technology
- Race, History, and American Society
- Academic Publishing and Open Access
- Respiratory viral infections research
- Innovations in Medical Education
- Themes in Literature Analysis
The Barbara Ann Karmanos Cancer Institute
2021-2024
Wayne State University
2021-2024
USA Mitchell Cancer Institute
2023
University of South Alabama
2023
Washington University in St. Louis
2023
University of Cincinnati
2023
Yahoo (United Kingdom)
2023
University of Miami
2023
UC Davis Health System
2023
Sylvester Comprehensive Cancer Center
2023
Vulvar squamous cell cancer (VSC) accounts for 90% of vulvar cancers. Next-generation sequencing studies VSC imply human papillomavirus (HPV) and p53 status play separate roles in carcinogenesis prognosis. We sought to describe the genomic landscape analyze immunologic profiles with respect HPV status. A total 443 tumors underwent tumor profiling. was performed on DNA isolated from formalin-fixed paraffin-embedded samples. PD-L1, microsatellite instability were tested by fragment analysis,...
PURPOSE The new CAP guideline published in August 2022 recommends using immunohistochemistry (IHC) to test for mismatch repair defects gastroesophageal (GE), small bowel (SB), or endometrial carcinoma (EC) cancers over next-generation sequencing assessment of microsatellite instability (NGS-MSI) immune checkpoint inhibitor (ICI) therapy eligibility and states there is a preference use IHC NGS-MSI colorectal (CRC). METHODS We assessed the concordance IHC-MMR from very large cohort across...
Introduction Ovarian cancer recurs in most High Grade Serous Cancer (HGSOC) patients, including initial responders, after standard of care. To improve patient survival, we need to identify and understand the factors contributing early or late recurrence therapeutically target these mechanisms. We hypothesized that HGSOC, response chemotherapy is associated with a specific gene expression signature determined by tumor microenvironment. In this study, sought determine differences immune...
To estimate the rate of concurrent surgery for locoregional gynecologic cancer and pelvic organ prolapse-urinary incontinence (POP-UI) to assess POP-UI within 5 years those who did not undergo surgery.This is a retrospective cohort study. The SEER-Medicare data set was used identify cases local or regional endometrial, cervical, ovarian diagnosed from 2000 2017. Patients were followed up diagnosis. We χ 2 tests categorical variables associated with having procedure hysterectomy hysterectomy....
The aim of this study was to evaluate the prognostic value peritoneal cytology status among other clinicopathological parameters in uterine serous carcinoma (USC). A retrospective 148 patients diagnosed with from 1997 2016 at two academic medical centers Detroit metropolitan area done. central gynecologic pathologist reviewed all available slides and confirmed histologic diagnosis each case USC. We assessed impact various on overall survival (OS) endometrial cancer-specific (ECSS). Those...
To evaluate risk of a second cancer and associated survival times in United States women with diagnosis cancer.The Surveillance Epidemiology End Results (SEER) database was queried for 2 cohorts aged 18 - 89 either an index gynecologic or non-gynecologic diagnosed between 1992 2017. Index cases were followed to determine if primary subsequently diagnosed; defined according SEER multiple histology coding rules. Standard Incident Ratios (SIR) latency intervals evaluated. Among those who...
It has been theorized that 75%-80% of febrile neutropenia (FN) is caused by endogenous pathogens, while up to 20% cases are thought be a viral infection. unknown if precautions such as masking and social distancing reduce the risk FN in susceptible populations.To determine whether coronavirus disease 2019 (COVID-19) infection mitigation efforts, namely distancing, were associated with reduction incidence FN.This was retrospective population based cohort study comparing 13 mo prior (Year 0)...
To determine if the origin of article published in Gynecologic Oncology ("Journal") is correlated with quality when measured per US institution and country, using an index citation (IOC) metric as a stand-in for quality.PubMed was used to query Journal from 2005 2020. Articles not deemed original research were excluded. A US-only cohort ("US-Only") evaluated separately entire ("Whole"). The IOC each calculated by dividing number citations listed PubMed days publication date 9/1/2021....
(Abstracted from Obstet Gynecol 2023;141:629–641) Most women diagnosed with a gynecologic cancer report symptoms related to pelvic organ prolapse or urinary incontinence (POP-UI) before and during their treatment. Often, these go untreated; however, several studies have suggested concurrent surgery for cancer, POP-UI is safe may reduce total surgeries but lack long-term follow-up data.
e17622 Background: 50% of endometrial atypical hyperplasia (AH) cases on sampling have concurrent cancer (EC) hysterectomy. Little data exists regarding molecular signatures that can predict the presence in patients with AH biopsy. Therefore, we set to characterize landscapes samples diagnosed EC final hysterectomy specimen, using matched controls. Methods: Karmanos Cancer Institute pathology database was searched for curettage or biopsy who had a within 6 months. Only adequate tissue next...