A5034958625- Breast Cancer Treatment Studies
- Patient-Provider Communication in Healthcare
- Metabolomics and Mass Spectrometry Studies
- Prostate Cancer Treatment and Research
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- scientometrics and bibliometrics research
- Statistical Methods and Bayesian Inference
- Diagnosis and treatment of tuberculosis
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Angiogenesis and VEGF in Cancer
- Cervical Cancer and HPV Research
- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Economic and Financial Impacts of Cancer
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- Palliative Care and End-of-Life Issues
- Lung Cancer Research Studies
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Statistical Methods and Inference
The Barbara Ann Karmanos Cancer Institute
2015-2024
Wayne State University
2015-2024
Bon Secours Hospital Cork
2022
Mount Sinai Hospital
2022
Jackson Memorial Hospital
2022
University of Louisville
2012-2014
Cambridge University Press
2010
New York University Press
2010
<p>Supplementary legends Supplementary Tables 1-3 Figures 1-8</p>
<div>Abstract<p>Genetic alterations play a pivotal role in various human diseases, particularly cancer. The androgen receptor (AR) is crucial transcription factor driving prostate cancer progression across all stages. Current AR-targeting therapies utilize competitive AR antagonists or pathway suppressors. However, therapy resistance often emerges due to mutations and splice variants, such as AR-v7. To overcome this, we developed ATC-324, an degrader using the innovative protein...
The current standard of care for the treatment small cell lung cancer (SCLC) is concurrent chemoradiation patients with limited-stage SCLC (LS-SCLC) and chemoimmunotherapy extensive-stage (ES-SCLC). backbone chemotherapy regimens in both a platinum-etoposide doublet: cisplatin traditionally preferred platinum agent curative intent setting, whereas carboplatin ES-SCLC because its favorable toxicity profile.To determine whether associated better survival outcomes than treating LS-SCLC...
Cancer clinical trial participation is low and inequitable. Partnering Around Clinical Trials (PACCT) addressed systemic interpersonal barriers through an observational study of eligibility intervention to improve patient-physician communication invitation rates.
Metaplastic breast carcinoma is an aggressive form of cancer that accounts for 0.5% to 3% all cancers.To study the clinicopathologic characteristics and outcomes this rare disease.Retrospective patients with a diagnosis metaplastic between 2000 2019. Hematoxylin-eosin-stained slides were reviewed additional clinical data obtained from electronic medical records. Univariable multivariable Cox proportional hazard regression analyses used determine associations overall survival several...
Problem statement: Lung cancer screening using X-rays has been controversial for many years.A major concern is whether lung really brings any survival benefits, which depends on effective treatment after early detection.The problem was analyzed from a different point of view and estimates were presented the projected lead time participants in program Johns Hopkins Project (JHLP) data.Method: The newly developed method estimation applied where lifetime T treated as random variable rather than...
We aimed to study the clinicopathologic and immunohistochemical (IHC) (CD117, c-Myc, p53) characteristics, overall survival of primary secondary breast angiosarcoma (BAS). This was a retrospective BAS cases diagnosed between 1997 2020 at our institution. Hematoxylin eosin-stained slides were reviewed for tumor morphology, margin status, lymph node metastasis. CD117, p53, D2-40, CD31, c-Myc IHC stains performed on 11 viable tissue blocks. Additional clinical information obtained from...
A nonlinear mixed-effects approach is developed for disease progression models that incorporate variation in age a Bayesian framework.We further generalize the probability model sensitivity to depend on at diagnosis, time spent preclinical state and sojourn time.The are then applied Johns Hopkins Lung Project data Health Insurance Plan Greater New York using Markov chain Monte Carlo compared with estimation method does not consider random-effects from age.Using models, we obtain only...
Abstract Context: The comparative outcomes of breast conserving surgery (BCS) with and without cavity shave margins are not well established. We aim to evaluate the impact each procedure on final margin status rate re-excision. Design: A total 529 cancer cases from our institution between 2013-2015 were included. Demographic clinicopathological data including type, tumor grade, status, re-excision rates collected. H&E slides positive (tumor ink) reviewed by two pathologists. Appropriate...
Cannabis (CAN) use has risen significantly over the last few decades. CAN potent immunosuppressive properties, which could antagonize effect of immunotherapy (IO). The impact on clinical cancer outcomes remains unclear.
Abstract Prostate cancer (PCa) progression is largely driven by the androgen receptor (AR), making it a prime target for therapy. However, therapy resistance often arises due to AR mutations and splice variants, such as AR-v7. AUTOTAC (AUTOphagy-TArgeting Chimera) novel protein degradation platform that utilizes autophagy-lysosomal pathway selectively degrade disease-causing proteins. In this study, we characterize ATC-324, an AUTOTAC-based degrader designed treatment of PCa. ATC-324...
e13166 Background: Epithelial-mesenchymal transition (EMT) is the process wherein polarized and cohesive epithelial cells lose their characteristics acquire a mesenchymal phenotype proceed to invasive form of tumor. Numerous regulators play role in complex signaling pathways that mediate EMT process. This study aims investigate immunohistochemical (IHC) expression several EMT-related markers implications on diagnosis prognosis breast cancer cohort Arab descent women. Methods: Patients...
Abstract Genetic alterations play a pivotal role in various human diseases, particularly cancer. The androgen receptor (AR) is crucial transcription factor driving prostate cancer (PCa) progression across all stages. Current AR-targeting therapies utilize competitive AR antagonists or pathway suppressors. However, therapy resistance often emerges due to mutations and splice variants, such as AR-v7. To overcome this, we developed ATC-324, an degrader using the innovative protein degradation...
This descriptive, single-arm study assessed the implementation and patient perceptions of an evidence-based Question Prompt List (QPL), ASQ brochure, across a network oncology clinics in diverse population.The QPL was revised collaboration with stakeholders. Implementation using RE-AIM framework. Eligible patients were scheduled for first appointment oncologist at any eight participating clinics. All participants received brochure completed three surveys: one baseline, immediately before,...
To determine if the origin of article published in Gynecologic Oncology ("Journal") is correlated with quality when measured per US institution and country, using an index citation (IOC) metric as a stand-in for quality.PubMed was used to query Journal from 2005 2020. Articles not deemed original research were excluded. A US-only cohort ("US-Only") evaluated separately entire ("Whole"). The IOC each calculated by dividing number citations listed PubMed days publication date 9/1/2021....
One of the most important and challenging "knowledge extraction" tasks in bioinformatics is reverse engineering genes, proteins, metabolites networks from biological data. Gaussian graphical models (GGMs) have been proven to be a very powerful formalism infer networks. Stand