A5055147072- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- COVID-19 Clinical Research Studies
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Long-Term Effects of COVID-19
- Optimal Experimental Design Methods
- Peroxisome Proliferator-Activated Receptors
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Antibiotic Use and Resistance
- Cardiac Arrest and Resuscitation
- Heavy Metal Exposure and Toxicity
- Alcoholism and Thiamine Deficiency
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Spine and Intervertebral Disc Pathology
- Trace Elements in Health
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
University of Louisville
2016-2025
Yunnan University
2025
Kaiser Permanente Roseville Medical Center
2024
American College of Surgeons
2024
James Graham Brown Foundation
2024
American College of Financial Services
2024
New York Proton Center
2022
Manhattan Institute for Policy Research
2022
Oregon Medical Research Center
2022
University of Pittsburgh
2022
Enteric dysbiosis plays an essential role in the pathogenesis of alcoholic liver disease (ALD). Detailed characterization alterations gut microbiome is needed for understanding their pathogenic ALD and developing effective therapeutic approaches using probiotic supplementation. Mice were fed liquid Lieber-DeCarli diet without or with alcohol (5% v/v) 6 weeks. A subset mice administered Lactobacillus rhamnosus GG (LGG) from to 8 Indicators intestinal permeability, hepatic steatosis,...
One of the defining characteristics a pre-metastatic niche, fundamental requirement for primary tumor metastasis, is infiltration immunosuppressive macrophages. How these macrophages acquire their phenotype remains largely unexplored. Here, we demonstrate that tumor-derived exosomes (TDEs) polarize toward an characterized by increased PD-L1 expression through NF-kB-dependent, glycolytic-dominant metabolic reprogramming. TDE signaling TLR2 and NF-κB leads to glucose uptake. TDEs also...
Abstract Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate plant-derived nanoparticles (PNP) on and metabolites in context cancer immunotherapy with humanized gnotobiotic mouse model. Specifically, show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae Lactobacillaceae mediated digalactosyldiacylglycerol (DGDG)...
Rationale: Despite 4 decades of intense effort and substantial financial investment, the cardioprotection field has failed to deliver a single drug that effectively reduces myocardial infarct size in patients. A major reason is insufficient rigor reproducibility preclinical studies. Objective: To develop multicenter, randomized, controlled, clinical trial-like infrastructure conduct rigorous reproducible evaluation cardioprotective therapies. Methods Results: With support from National...
In Brief Study Design. Retrospective, observational. Objective. To simulate what episodes of care in spinal surgery might look like a bundled payment system and to evaluate the associated costs characteristics. Summary Background Data. Episode-based bundling has received considerable attention as potential method help curb rise health spending is being investigated new model part Affordable Care Act. Although earlier studies payments number surgical settings, very few focused on spine...
SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes clinical disease called 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, significant number of patients develop severe critical disease. Patients with commonly present pneumonia may progress to life-threatening acute distress syndrome (ARDS). also predisposed venous and arterial thromboses associated poorer prognosis. The study identified the emergence...
INTRODUCTION: We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking patients with alcohol use disorder moderately severe alcohol-associated hepatitis. METHODS: Forty-six male female individuals moderate hepatitis (12 ≤ model for end-stage disease score < 20, aged 21–67 years) received either LGG (n = 24) or placebo 22). Data were collected/assessed at baseline 1, 3, 6 months. RESULTS: treatment was associated a significant...
Abstract The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of progression. Neutral ceramidase a key regulator ceramide, the central intermediate sphingolipid metabolism. contribution neutral to reprogramming not well understood. Here, we find that deletion multiple breast models female mice accelerates growth. Our result show Ly6C + CD39 tumor-infiltrating CD8 T are enriched display an exhausted phenotype. Deletion myeloid vivo vitro induces exhaustion...
Studying and understanding the joint effect of combined treatments is important in pharmacology development combination therapies. The Loewe additivity model one best general reference models for evaluating drug interactions. Based on this model, synergy occurs when interaction index less than one, while antagonism greater one. We expanded meaning index, propose a procedure to calculate its associated confidence interval under assumption that dose-effect curve single agent follows Chou...
Bone morphogenetic protein (BMP) is used in tens of thousands spinal fusions each year. A trial evaluating a high-dose BMP formulation demonstrated that its use may be associated with an increased risk cancer.To evaluate whether BMP, as commonly today, cancer or benign tumors.We performed retrospective study using the Thomson Reuter MarketScan database. We retained all patients who had no previous diagnosis tumor and at least 2 years uninterrupted enrollment database before after their...
In Brief Study Design. A retrospective, cross-sectional study. Objective. To evaluate racial disparities in outcomes of lumbar stenosis surgery. Summary Background Data. Racial inequalities have been described the cardiovascular and orthopedic procedures. There minimal investigation complications costs laminectomies fusions. Methods. We analyzed Medicaid data set Thomson Reuter's MarketScan database. African-American non-Hispanic white patients who underwent laminectomy or fusion for with at...
A novel framework for the classification of acute rejection versus nonrejection status renal transplants from 2-D dynamic contrast-enhanced magnetic resonance imaging is proposed. The consists four steps. First, kidney objects are segmented adjacent structures with a level set deformable boundary guided by stochastic speed function that accounts fourth-order Markov-Gibbs random field model kidney/background shape and appearance. Second, Laplace-based nonrigid registration approach used to...
Propensity score based statistical methods, such as matching, regression, stratification, inverse probability weighting (IPW), and doubly robust (DR) estimating equations, have become popular in average treatment effect (ATE) among treated (ATT) observational studies. is the conditional receiving a assignment with given covariates, propensity usually estimated by logistic regression. However, misspecification of model may result biased estimates for ATT ATE. As an alternative, generalized...
Background and Aims Fibroblast growth factor (FGF) 1 demonstrated protection against nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic obese mice by an uncertain mechanism. This study investigated the therapeutic activity mechanism of a nonmitogenic FGF1 variant carrying 3 substitutions heparin‐binding sites (FGF1 △HBS ) NAFLD. Approach Results administration was effective 9‐month‐old homozygous mutation leptin receptor gene ( db/db with NAFLD; weight, lipid deposition,...
Abstract Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success remyelination MS plaques return function. As a central player neuroinflammation, activation polarization microglia/macrophages (M/M) that modulate inflammatory niche cytokine components demyelination lesions may impact OPC progression remyelination. However, dynamic behaviors M/M OPCs during spontaneous are poorly...
Abstract Exposure to the environmental toxicant cadmium (Cd) contributes development of obesity-associated diseases. Obesity is a risk factor for spectrum unhealthy conditions including systemic metabolic dyshomeostasis. In present study, effects whole-life exposure environmentally-relevant concentrations Cd on essential metal distribution in adult mice fed high-fat diet (HFD) were examined. For these studies, male and female exposed Cd-containing drinking water >2 weeks before breeding....
Radiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data on dynamics between plasma ctDNA concentrations radiographic lacking. We evaluated relationship measures burden 30 melanoma systemic treatment. In 9 no evidence disease over total 15 time points, were undetectable. 21 burden, was detected 81 %...
Research Article| January 01, 2005 A statistical approach to estimate the 3D size distribution of spheres from 2D distributions Maiying Kong; Kong 1Department Mathematics, Indiana University, Bloomington, 47405, USA Search for other works by this author on: GSW Google Scholar Rabi N. Bhattacharya; Bhattacharya Christina James; James 2Indiana Geological Survey, Abhijit Basu 3Department Sciences, Author and Article Information Publisher: Society America Received: 12 Feb 2003 Revision 11 Apr...
To assess the effectiveness of guidelines and education on empirical therapy for community-acquired pneumonia.Administrative records children with a primary diagnosis pneumonia from January 2007 to September 2009 were reviewed. Antimicrobial use was measured monthly over 3 periods: (1) before creation an antimicrobial stewardship task force (ASTF), (2) after ASTF formation but release use, (3) guideline release. time assessed by using quasi-binomial logistic regression models that...
Surgery remains the mainstay for management of lumbar spondylolisthesis and is considered an effective therapeutic modality following unsuccessful nonoperative treatment. Surgical procedures include decompression, decompression with instrumented arthrodesis, noninstrumented arthrodesis. The purpose this study was to examine complications, reoperation rates, health-care costs associated each these procedures.The MarketScan database utilized identify 16,556 patients a primary diagnosis who...