A5023708993- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Sarcoidosis and Beryllium Toxicity Research
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Pulmonary Hypertension Research and Treatments
- Neuroendocrine Tumor Research Advances
- Respiratory Support and Mechanisms
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Ion Channels and Receptors
- Autoimmune and Inflammatory Disorders
- Infectious Diseases and Tuberculosis
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
- Occupational and environmental lung diseases
Medical University of South Carolina
2002-2023
MUSC Hollings Cancer Center
2008-2023
University of Louisville
2012-2021
University of Alberta
2019
Lung Institute
2019
King Saud University
2019
Alexandria University
2019
University of Pittsburgh Medical Center
2013-2017
Northwestern University
2015-2017
Kingmed Diagnostics
2017
Background and Study Aims: The accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) depends on immediate specimen review by a cytopathologist. Stromal tumors, lymphoma, well-differentiated pancreatic cancer are difficult to diagnose the basis cytology alone. To overcome these limitations, 19-gauge Trucut needle has been developed obtain histological samples at EUS. This pilot study compares adequacy diagnostic EUS-guided biopsy (EUS-TNB) with EUS-FNA. Patients Methods: A...
The clinical and pathologic features of 109 cases respiratory bronchiolitis (RB) identified from review 156 consecutive surgical lung biopsy specimens were studied. A total 107 the (98%) occurred in smokers, including all 83 current smokers 24 49 ex-smokers (49%). RB persisted some patients for many years after stopping smoking, occurring one third 5 quitting, patient 32 afterwards. correlation was found between degree cytoplasmic pigmentation macrophages number pack-years smoked also...
Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead cancer. In this study, we demonstrate in K-rasLA1 mice, CS markedly enhances the tumour burden and genetic deletion of leukotriene B4 receptor-1 (BLT1−/−) attenuates increase. Pulmonary neutrophilic inflammation induced by is significantly reduced BLT1−/−K-rasLA1 mice. induces LTB4 production mast cells macrophages independent inflammasome activation. air-pouch...
The marked reduction in the potent early bactericidal activity of isoniazid during initial phase antituberculosis (anti-TB) therapy has been attributed not only to depletion logarithmically growing bacilli but also emergence resistance. We studied anti-TB and its ability select for drug-resistant mutant strains guinea pigs, which histopathology TB closely resembles that human TB. Prior mouse passage did appear enhance virulence Mycobacterium tuberculosis pigs. human-equivalent dose was...
Abstract These studies were undertaken to determine the potential role of thromboxane receptors (TP) in bladder cancer. The data reported herein show that expression TP-β receptor protein is increased tissue obtained from patients with cancer and associated a significantly poorer prognosis (P < 0.005). Bladder cell lines express isoform, unlike immortalized nontransformed urothelial cells (SV-HUC) only TP-α isoform. expression, but not TP-α, promoted proliferation, migration, invasion...
Abstract BACKGROUND Ets is a large family of transcriptional regulators with functions in most biological processes. While the gene, prostate‐derived epithelial factor (PDEF), expressed tissues, PDEF protein expression has been found to be reduced or lost during cancer progression. The goal this study was examine mechanism for and biologic impact altered prostate cancer. METHODS specimens examined by immunohistochemistry. RNA cell lines were measured q‐PCR Western blot, respectively....
Recent in vitro pharmacokinetic data suggest that the currently recommended dose of pyrazinamide may be suboptimal for killing intracellular bacilli humans. We evaluated a range doses against and extracellular Mycobacterium tuberculosis chronically infected mice guinea pigs, respectively. Antibiotics were given five times weekly 4 weeks beginning 28 days after infection. Human-equivalent isoniazid reduced lung bacterial counts 10-fold each species. Pyrazinamide at 1/4 1/2 human-equivalent...
Factors underlying gastroparesis are not well defined, nor is the mechanism of action gastric electrical stimulation (GES). We hypothesized that GES acts via several mechanisms related to disordered pathophysiology.We studied 43 consecutive eligible patients with gastroparetic symptoms, previously evaluated by two methods in each five core areas: inflammatory, autonomic, enteric, electrophysiologic, and hormonal; also categorized GI metabolic status, illness quantification, physiology. then...
Despite the associated morbidity and mortality, underlying mechanisms leading to development of acute lung injury (ALI) remain incompletely understood. Frequently, ALI develops in hospital, coinciding with institution various therapies, including use supplemental oxygen. Although pathological evidence hyperoxia-induced humans has yet be proven, animal studies involving high oxygen concentration reproducibly induce ALI. The potentially injurious role lower presumably safer concentrations not...
To develop an animal model of intraocular tuberculosis (TB) with features pulmonary TB and extrapulmonary dissemination to the eye.Hartley strain guinea pigs were infected via aerosol route virulent Mycobacterium tuberculosis. One group was a relatively low bacterial inoculum received no treatment. A second high-dose infection treated first-line anti-TB drugs isoniazid, rifampin, pyrazinamide. Development ocular lesions documented by histological analysis, acid-fast staining, real-time...
ABSTRACT Infection of the lower respiratory tract by influenza A viruses results in increases inflammation and immune cell infiltration lung. The dynamic relationships among lung microenvironments, lung, systemic host responses during infection remain poorly understood. Here we used extensive systematic histological analysis coupled with live imaging to gain access these ferrets infected 2009 H1N1 pandemic virus (H1N1pdm virus). Neutrophil levels rose lungs H1N1pdm virus-infected 6 h...
Mediastinal lymph nodes are the most common site of tumor spread in non-small cell lung cancer (NSCLC). We hypothesized that micrometastatic disease could be detected by reverse transcription-polymerase chain reaction (RT-PCR) for expression human telomerase transcriptase (hTERT) mediastinal and a minimally invasive technique (endoscopic ultrasound-guided fine-needle aspiration [EUS-FNA]) is capable sampling PCR analysis without surgery. were sampled with EUS-FNA patients NSCLC negative...
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Non-small cell lung cancer (NSCLC) is the most common cancer-related cause of death for both men and women in US. Standard therapies patients with NSCLC include surgery, chemotherapy, radiation therapy, stage disease dictates choice therapy. The current staging system uses American Joint Committee on Cancer TNM system, its goal to classify into groups based extent disease. This relies heavily pathologic evaluation primary tumor (T), regional nodes (N), distant metastases (M). Patients whom...
Tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) is an important regulator metalloproteinase activity in many types disease, including atherosclerosis, neoplasia, and inflammatory conditions. Among TIMPs, TIMP-3 uniquely binds the extracellular (ECM). We performed IHC staining on 17 tissue microarrays containing >1500 samples to determine location ECM a variety predominantly vascular tissues. found unique pattern renal arterioles, small pulmonary vessels parenchyma, Bruch's...