A5005147297- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Atrial Fibrillation Management and Outcomes
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 detection and testing
- Neurological and metabolic disorders
- COVID-19 and healthcare impacts
- Hematopoietic Stem Cell Transplantation
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- CAR-T cell therapy research
- Renal and related cancers
- Biosimilars and Bioanalytical Methods
University of California, Los Angeles
2023-2024
Wayne State University
2020-2023
The Barbara Ann Karmanos Cancer Institute
2020-2023
Detroit Medical Center
2020-2022
Saint Francis Hospital
2022
Woodhull Medical and Mental Health Center
2022
Veterans Health Administration
2021
University of Hawaii System
2020
Background Hospitalization of patients infected with the severe acute respiratory syndrome virus 2 (SARS-CoV-2) have remained considerable worldwide. Patients often develop complications and high mortality rates. The cycle threshold (Ct) value derived from nasopharyngeal swab samples using real time polymerase chain reaction (RT-PCR) may be a useful prognostic marker in hospitalized SARS-CoV-2 infection, however, its role predicting course pandemic has not been evaluated thus far. Methods We...
The current standard of care for the treatment small cell lung cancer (SCLC) is concurrent chemoradiation patients with limited-stage SCLC (LS-SCLC) and chemoimmunotherapy extensive-stage (ES-SCLC). backbone chemotherapy regimens in both a platinum-etoposide doublet: cisplatin traditionally preferred platinum agent curative intent setting, whereas carboplatin ES-SCLC because its favorable toxicity profile.To determine whether associated better survival outcomes than treating LS-SCLC...
The pandemic of coronavirus disease 2019 has emerged in late infecting millions people worldwide. Diabetes mellitus (DM) been associated with severe illness and mortality mainly due to acute respiratory distress syndrome. We report a case middle-aged man DM COVID-19 who developed seizure altered mental status, found have diabetic ketoacidosis (DKA), kidney injury, hypovolemic shock, hyperammonemia all contributing metabolic encephalopathy. He was admitted the ICU subsequently intubated for...
The introduction of immunotherapy has revolutionized the treatment and improved outcomes multiple types cancer. Although breast cancer is a less immune-responsive tumor type, incorporation pembrolizumab into chemotherapy regimens in neoadjuvant first-line metastatic setting for triple-negative disease outcomes. However, use this type associated with spectrum adverse events. rarely affected, kidneys can be target immunotherapy, leading to irreversible injury if not recognized addressed early....
Background: Immune checkpoint inhibitors (ICIs) are the newest class of anticancer drugs. Pneumonitis is increasingly being recognized as a potential complication these agents. Methods: We conducted retrospective study patients who received ICIs at comprehensive cancer center. collected data on demographics, type malignancy, ICI agent, incidence pneumonitis up to 6 weeks after receiving clinical characteristics, and risk factors for overall survival in develop pneumonitis. Results: A total...
Sweet syndrome (SS), also referred as acute febrile neutrophilic dermatosis, is an inflammatory process characterised by the abrupt appearance of erythematous papules or nodules with predominant infiltration in dermis. Fever and neutrophilia are common presenting features. However, extracellular manifestations, including ocular musculoskeletal, may occur. SS divided into three subtypes: classical (or idiopathic), malignancy associated drug induced. Medication-induced subtype accounts for up...
Abstract We report a downward trend in the initial SARS-CoV-2 viral load nasopharyngeal swab samples of hospitalized patients with COVID-19 Detroit, Michigan, coinciding decrease number deaths during April-June 2020. A gradual reflected progression pandemic.
To evaluate the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initial viral load (iVL) and incidence myocardial injury (MCI) in hospitalized patients with SARS-CoV-2 infection, we conducted a retrospective longitudinal study who had nasopharyngeal swab sample on admission that returned positive result for by polymerase chain reaction between April 4 June 5, 2020. The cycle threshold (Ct) value was used as surrogate iVL level, Ct level 36 or less elevated greater...
Synovial sarcomas are rare malignant tumors that originate from primitive pluripotent mesenchymal stem cells look similar to the developing synovium, but histologically unrelated it. Sarcomas commonly metastasize lungs and surrounding pleura, with a documented incidence as high 85% for pleural-based metastases. The of spontaneous pneumothorax in patients is only 1.9%, synovial sarcoma being third most common type associated pneumothorax. While surgical resection usually treatment localized...
Total-body irradiation (TBI)-based conditioning regimen is preferred in acute lymphoblastic leukemia (ALL). We retrospectively evaluated allogeneic stem cell transplant (alloSCT) outcomes of 86 adult ALL patients complete remission (CR) who received TBI-containing reduced intensity (RIC) (Flu/Mel/TBI = 31) and myeloablative (MAC) (VP16/TBI 47; CY/TBI 8) between January 2005 December 2019. All peripheral blood allografts. Patients the RIC group were older than MAC (61 years old versus 36...
Fumarate hydratase-deficient renal cell carcinomas are an aggressive form of kidney cancer that often results in poor prognosis and high fatality rates. The implications somatic mutations not well described, standard treatment has been established for this carcinoma subtype. Further molecular characterization fumarate could potentially help to identify biomarkers can be exploited with future targeted therapies. 2199 were analyzed by DNA sequencing (592-gene panel) whole- transcriptome 40...
The prognosis of advanced non-small cell lung cancer (NSCLC) has significantly improved for certain patients with the development epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, metastatic NSCLC long-term survival are still rare. Our 66-year-old male patient was admitted to hospital treatment pneumonia. A chest CT scan done revealed a left upper lobe mass; computed tomography (CT)-guided fine-needle aspiration (FNA) in 2010 revealing adenocarcinoma. staging...
In men, prostate cancer is the second most diagnosed worldwide. Typical sites for metastasis include bone, lung, and liver. Prostate with gastrointestinal involvement, particularly rectal, has been rarely reported in literature. As patients rectal invasion may present symptoms similar to those of other pathologies, such as anal fissures carcinoma itself, misdiagnosis delays care can result. Direct visualization rectum via endoscopy, along biopsy, allows clinicians make an accurate timely...
Lutetium-177 (177Lu) dotatate is a type of peptide receptor radioligand therapy (PRRT) using radiolabeled somatostatin for patients with progressive receptor-positive gastrointestinal neuroendocrine tumors. While cases therapy-related myeloid neoplasms (t-MN) have been described as consequence 177 Lu dotatate, there are no reports hemolytic anemia associated therapy. We present case 68-year-old woman metastatic low-grade tumor who presented four weeks after the second dose 177Lu fatigue and...
Lacosamide (LCM)is an anti-epileptic drug associated with a serious cardiac event. Herein, we report case of 45-year-old male patient lacosamide induced-bradycardia.
Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus (DM). Cerebral edema (CE) can complicate DKA management. We report patient with no significant medical history who presented and new-onset DM; she received the standard management regular insulin IV fluids, resulted in rapid drop serum osmolality, patient`s mental status deteriorated became nonresponsive, brain imaging confirmed CE, few days later was declared dead by neurology. This case highlights...