A5001375492- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Neutropenia and Cancer Infections
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Nail Diseases and Treatments
- Herpesvirus Infections and Treatments
- Ocular Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Hematological disorders and diagnostics
- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
- Clostridium difficile and Clostridium perfringens research
- Plant Pathogens and Fungal Diseases
- Mycobacterium research and diagnosis
- Drug-Induced Adverse Reactions
- Pneumonia and Respiratory Infections
- Fungal Biology and Applications
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Infectious Diseases and Tuberculosis
- Mycotoxins in Agriculture and Food
Wayne State University
2015-2024
The Barbara Ann Karmanos Cancer Institute
2014-2024
Michigan United
2020-2023
Detroit Medical Center
1994-2021
Museum of Heilongjiang Province
2021
Centers for Disease Control and Prevention
2019
Nizam's Institute of Medical Sciences
2018
Institute of Medical Sciences
2018
Harper University Hospital
2005-2017
Marymount University
2017
Voriconazole is a broad-spectrum triazole that active against aspergillus species. We conducted randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis.
Invasive fungal infections are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation.
Superficial and systemic fungal infections are a major problem among severely immunocompromised patients who undergo bone marrow transplantation. We performed doubleblind, randomized, multicenter trial in which receiving transplants were randomly assigned to receive placebo or fluconazole (400 mg daily). Fluconazole was administered prophylactically from the start of conditioning regimen until neutrophil count returned 1000 per microliter, toxicity suspected, infection suspected proved.
Background. Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Current treatments provide limited benefit. Posaconazole extended-spectrum triazole with vitro vivo activity against Aspergillus species.
The impact of newer immunosuppressive and antimicrobial prophylactic agents on the pattern infectious complications following kidney transplantation has not been well studied.This is an observational study in 127 adult recipients transplanted from 2001 to 2004. Patients received thymoglobulin (ATG) (50%) or basiliximab for induction were maintained mycophenolate mofetil, either tacrolimus (73%) sirolimus (SRL) (27%), prednisone (79%). Antimicrobial prophylaxis included perioperative...
Background: Allogeneic hematopoietic stem-cell transplant recipients often receive fluconazole or an amphotericin B preparation for antifungal prophylaxis. Because of concerns about fungal resistance with and toxicity B, alternative prophylactic regimens have become necessary. Objective: To compare the efficacy safety intravenous oral itraconazole long-term prophylaxis infections. Design: Open-label, multicenter, randomized trial. Setting: Five transplantation centers in United States....
Journal Article Nephrotoxicity of vancomycin, alone and with an aminoglycoside Get access Michael J. Rybak, Rybak aCollege Pharmacy Allied Health ProfessionsDetroit, Michigan 48201, USAdDepartment Services, Detroit Receiving Hospital University CenterDetroit, USA Corresponding author: Dr J Department Center, 4201 St Antoine Boulevard, Detroit, Search for other works by this author on: Oxford Academic PubMed Google Scholar Lisa M. Albrecht, Albrecht cCollege Pharmacy, Illinois at Chicago...
Objective: To evaluate the efficacy and safety of fluconazole for prevention fungal infections. Design: A randomized, placebo-controlled, double-blind, multicenter trial. Patients: Adults (257) undergoing chemotherapy acute leukemia. Intervention: Patients were randomly assigned to receive either (400 mg orally once daily or 200 intravenously every 12 hours) placebo. The study drug was started at initiation continued until recovery neutrophil count, development proven suspected invasive...
We report a randomized, double-blind, multicenter trial in which amphotericin B colloidal dispersion (ABCD [Amphotec]; 6 mg/kg/day) was compared with (AmB; 1.0–1.5 for the treatment of invasive aspergillosis 174 patients. For evaluable patients ABCD and AmB groups, respective rates therapeutic response (52% vs. 51%; P = 1.0), mortality (36% 45%; =.4), death due to fungal infection (32% 26%; =.7) were similar. Renal toxicity lower (25% 49%; =.002) median time onset nephrotoxicity longer (301...
Invasive candidiasis is a major nosocomial infection that difficult to diagnose. Few biochemically defined markers of invasive are known. Initial findings suggested the presence candida enolase in blood may be novel marker for candidiasis.
Background: Adults and children in the United States get two to six colds per year. Evidence that zinc is effective therapy for inconsistent. Objective: To test efficacy of acetate lozenges reducing duration symptoms common cold. Design: Randomized, double-blind, placebo-controlled trial. Setting: Detroit Medical Center, Detroit, Michigan. Patients: 50 ambulatory volunteers recruited within 24 hours developing Intervention: Participants took one lozenge containing 12.8 mg or placebo every 2...
Study Objective. To analyze the pharmacokinetics of posaconazole administered as prophylaxis for invasive fungal infections in recipients hematopoietic stem cell transplants (HSCTs) who have graft‐versus‐host disease (GVHD). Design. Pharmacokinetic analysis a subset posaconazole‐treated patients from large, multicenter, phase III, randomized, double‐blind, double‐dummy, parallel‐group trial that compared with fluconazole. Setting. Ninety international medical centers. Patients. The comprised...
This Phase 1B study showed that a single tablet of 300 mg posaconazole, given once daily as prophylaxis to 210 patients at risk for invasive fungal disease, was safe reported posaconazole oral suspension and achieved steady-state >500 ng/mL all but one patient.
ABSTRACT Posaconazole tablets, a new oral formulation of posaconazole, can be effective when given as antifungal prophylaxis to neutropenic patients at high risk for invasive fungal infection (e.g., those with acute myelogenous leukemia or myelodysplastic syndrome). Such effectiveness might specifically important poor intake because nausea, vomiting, chemotherapy-associated mucositis. This was prospective, global study in high-risk characterize the pharmacokinetics and safety profile...
Abstract Background Cytomegalovirus (CMV) infection remains an important cause of morbidity and mortality in allogeneic hematopoietic cell transplant (allo-HCT) recipients. CMV cell-mediated immunity (CMV-CMI) as determined by a peptide-based enzyme-linked immunospot (ELISPOT) assay may identify patients at risk for clinically significant (CS-CMVi). Methods The CS-CMVi was defined viremia and/or disease necessitating antiviral therapy. CMV-CMI characterized high when the intermediate-early 1...
Abstract The epidemiology of invasive aspergillosis (IA) is evolving. To define the patient groups who will most likely benefit from primary or secondary Aspergillus prophylaxis, particularly those whose medical conditions and IA risk change over time, it helpful to depict populations their periods in a temporal visual model. Sankey approach provides dynamic figure understand for various populations. While depicted within this article static, an internet-based version could provide pop-up...
ABSTRACT We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, results were compared with those obtained for Candida species. Exposure fumigatus conidia to varying concentrations (1.25 10 μg/ml) resulted in cellular death; cytocidal effect was concentration dependent. In contrast, no killing albicans occurred presence at as high μg/ml, although candidal growth inhibited drug-free control. Amphotericin B μg/ml), other hand,...
Zinc deficiency is a common nutritional problem in adult sickle-cell disease (SCD) patients. Hyperzincuria and increased requirement of zinc due to continued hemolysis SCD are probable bases for these affects adversely T-helper1 (TH1) functions cell mediated immunity interleukin (IL)-2 production decreased deficient subjects. We hypothesized that supplementation will improve function decrease incidence infections patients with SCD. tested this hypothesis 32 subjects who were divided three...
We investigated the in vitro susceptibilities of clinical and laboratory-selected Aspergillus spp. to posaconazole, compared results with those obtained for amphotericin B, itraconazole voriconazole. Conidial suspensions from isolates (284 fumigatus, 66 niger, 31 flavus 43 spp.) resistant A. fumigatus (15 25 12 voriconazole) were prepared their various antifungal agents determined using a previously described broth macrodilution technique. The geometric mean MICs (mg/L) posaconazole (0.17 ±...
Given the limited information on Clostridium difficile infection (CDI) during hematopoietic stem cell transplantation (HSCT), we examined recent epidemiology of CDI in HSCT recipients at our institution. During two-yr retrospective study period (2005-2006), 361 transplants were performed: 60% allogeneic and 40% autologous. Among all hospitalized patients a non-outbreak setting, rates ninefold higher than those general 1.4-fold with cancer (24.0 vs. 2.6 16.8/10,000 patient-days respectively)....