A5026834279- Hematopoietic Stem Cell Transplantation
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Acute Myeloid Leukemia Research
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- Animal Virus Infections Studies
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Viral Infections and Immunology Research
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Transgenic Plants and Applications
- RNA Interference and Gene Delivery
Hormel (United States)
2023-2025
University of Minnesota
2023-2025
Scripps Institution of Oceanography
2024
Washington State University Spokane
2024
Georgia Highlands College
2024
Scripps Research Institute
2012-2023
Hackensack University Medical Center
2023
University of Oxford
2022
University of Cambridge
2022
Human Sciences Research Council
2022
Invasive fungal infections are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation.
Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) time. This study used central database Center for International Blood Marrow Transplant Research (CIBMTR) to describe time cGVHD incidence, nonrelapse mortality, risk factors cGVHD. The 12-year period was divided into 3 intervals, 1995 1999, 2000 2003, 2004 2007, included 26,563 patients with acute leukemia, myeloid...
VIPERdb (http://viperdb.scripps.edu) is a relational database and web portal for icosahedral virus capsid structures. Our aim to provide comprehensive resource specific the needs of virology community, with an emphasis on description comparison derived data from structural computational analyses capsids. In current release, VIPERdb2, we implemented useful novel method represent protein residues in asymmetric unit (IAU) using azimuthal polar orthographic projections, otherwise known as Φ–Ψ...
Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack accurate structural information. Here, we report x-ray structure at 3.5 angstrom resolution 150-megadalton capsid containing nearly 1 million amino acids. We describe interactions between major protein (hexon) and several accessory molecules that stabilize capsid. The virus also reveals an altered association penton base trimeric fiber protein, perhaps reflecting early event in cell entry....
Acute graft-versus-host disease (GVHD) causes substantial morbidity and mortality after human leukocyte antigen (HLA)-identical sibling transplants. No large registry studies of acute GVHD risk factors have been reported in two decades. Risk may changed this interval as transplant-related techniques evolved.
Self-assembly of viral proteins into icosahedral capsids is an interesting yet poorly understood phenomenon which elucidation may aid the exploration beneficial applications in materials science and medicine. Using molecular dynamics simulations coarse-grained models for capsid proteins, we show that competition between formation full nonidealized structures strongly dependent upon protein concentration temperature, occurring kinetically as a cascade elementary reactions free monomers are...
In a prior multicenter randomized controlled trial, we found that 12-week course of extracorporeal photopheresis (ECP) plus standard immunosuppressive therapy resulted in several beneficial outcomes patients with corticosteroid-refractory/intolerant/dependent chronic graft-versus-host disease (GVHD). Here, report the results an open-label crossover ECP study 29 eligible participants initially to care non-ECP (control) arm. Eligible for were control arm who either (1) had progression...
Adenovirus cement proteins play crucial roles in virion assembly, disassembly, cell entry, and infection. Based on a refined crystal structure of the adenovirus at 3.8-Å resolution, we have determined structures all (IIIa, VI, VIII, IX) their organization two distinct layers. We significantly revised recent cryoelectron microscopy models for IIIa IX show that both are located capsid exterior. Together, exclusively stabilize hexon shell, thus rendering penton vertices weakest links capsid....
Ibrutinib, a Bruton tyrosine kinase inhibitor, is approved for treatment of various B-cell malignancies. In ibrutinib clinical studies, low-grade haemorrhage was common, whereas major (MH) infrequent. We analysed the incidence and risk factors MH from 15 studies (N = 1768), including 4 randomised controlled trials (RCTs). Rates any-grade bleeding were similar single-agent combinations (39% 40%). Low-grade more common in ibrutinib-treated than comparator-treated patients (35% 15%), early not...
The number of icosahedral-capsid structures determined at a near-atomic level resolution is growing rapidly as advances in synchrotron radiation sources, fast-readout detectors, and computer hardware software are made. Hence, there an increasing need to organize these mega-assemblies into uniform easy-to-use database. coordinates the deposited Protein Data Bank (PDB) (2) follow variety conventions which icosahedral symmetry axes oriented differently orthogonal coordinate system. While trying...
The water-selective pathway through the aquaporin-1 membrane channel has been visualized by fitting an atomic model to a 3.7-Å resolution three-dimensional density map. This map was determined analyzing images and electron diffraction patterns of lipid-reconstituted two-dimensional crystals preserved in vitrified buffer absence any additive. aqueous is characterized size-selective pore that ≈4.0 ± 0.5Å diameter, spans length ≈18Å, bends ≈25° as it traverses bilayer. narrow connected wide,...
VIPERdb (http://viperdb.scripps.edu) is a database for icosahedral virus capsid structures. Our aim to provide comprehensive resource specific the needs of structural virology community, with an emphasis on description and comparison derived data from energetic analyses capsids. A relational implementation based schema macromolecular structure makes highly accessible user, allowing detailed queries at atomic level. Together curation practices that maintain uniformity, this will facilitate...
Directed self-assembly of designed viral capsids holds significant potential for applications in materials science and medicine. However, the complexity preparing these systems assembly difficulty quantitative experimental measurements on process have limited access to critical mechanistic questions that dictate final product yields isomorphic forms. Molecular simulations provide a means elucidating proteins into icosahedral are focus present study. Using geometrically realistic...
Religiosity and spirituality have been associated with better survival in large epidemiologic studies. This study examined the relationship between spiritual absence 1-year all-cause mortality allogeneic hematopoietic stem cell transplant (HSCT) recipients. Depression problematic compliance were as possible mediators of a significant absence-mortality relationship. Eighty-five adults (mean = 46.85 years old, SD 11.90 years) undergoing evaluation for HSCT had routine psychologie prior to...