A5018932514- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Gene expression and cancer classification
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- RNA and protein synthesis mechanisms
- Cancer Risks and Factors
- Renal cell carcinoma treatment
- Economic and Financial Impacts of Cancer
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Bacterial Genetics and Biotechnology
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
University of Iowa Hospitals and Clinics
2016-2025
University of Iowa
2014-2023
Gynecologic Oncology Group
2022
University of Siena
2021
Levine Cancer Institute
2020
Mater Research
2019
Translational Research Institute
2019
The University of Queensland
2019
University of Saskatchewan
2016-2018
Australian National University
2018
The status of p53 in a tumor can be inferred by next-generation sequencing (NGS) or immunohistochemistry (IHC). We examined the association between IHC and sequence whether alone, integrated with TP53 NGS, predicts outcome.From GOG-86P, randomized phase II study chemotherapy combined either bevacizumab temsirolimus advanced endometrial cancer, 213 cases had protein expression data measured NGS data. An analysis was designed to integrate presence absence mutation. These variables were further...
Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was characterize a large, commonly employed panel obtained from American Type Culture Collection (ATCC 30-4500 K) enable researchers make more informed decisions in selecting for specific studies. Information about these wide variety sources. In addition, new information pathways that activated within each line generated. We determined key protein...
Tumor suppressor p53 is responsible for enforcing cell cycle checkpoints at G1/S and G2/M in response to DNA damage, thereby allowing both normal tumor cells repair before entering S M. However, with absent or mutated are able activate alternative signaling pathways that maintain the checkpoint, which becomes uniquely critical survival of such cells. We hypothesized abrogation G2 checkpoint might preferentially sensitize p53-defective DNA-damaging agents spare intact function. The tyrosine...
<h3>Importance</h3> Surgical site infections increase patient morbidity and health care costs. The Centers for Disease Control Prevention emphasize improved basic preventive measures to reduce bacterial transmission among patients undergoing surgery. <h3>Objective</h3> To assess whether can perioperative<i>Staphylococcus aureus</i>transmission surgical infections. <h3>Design, Setting, Participants</h3> This randomized clinical trial was conducted from September 20, 2018, 2019, 19 surgeons...
In previous studies, neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary cytoreductive as initial treatment for advanced epithelial ovarian cancer. Our study aimed compare surgical and survival outcomes between the two treatments in a large national database.Data were extracted from National Cancer Database January 2004 December 2015. Patients with FIGO (International Federation of Gynecologists Obstetricians) stage III-IV cancer known sequence...
We assessed the efficacy of cediranib, olaparib, and cediranib/olaparib compared with standard-of-care chemotherapy (SOC) in platinum-resistant or platinum-refractory epithelial ovarian cancer (PROC).
Venous thromboembolisms (VTEs) have been a leading secondary cause of death among ovarian cancer patients, prompting multiple studies risk factors. The objective this meta-analysis is to quantify the associations between VTE and most commonly reported factors patients. PubMed, Embase, Cumulative Index Nursing Allied Health Literature (CINAHL) were used identify observational studies. Two reviewers independently abstracted data assessed quality via Newcastle–Ottawa tool. A random effects...
Translation termination is promoted by class 1 and 2 release factors in all domains of life. While the role bacterial factors, RF1 RF2, translation well understood, precise contribution factor, RF3, to this process remains less clear. Here, we use a combination binding assays pre-steady state kinetics provide kinetic thermodynamic framework for understanding translational GTPase RF3 termination. First, find that GDP GTP have similar affinities that, on average, t 1/2 nucleotide dissociation...
In bacteria, stop codons are recognized by two similar class 1 release factors, factor (RF1) and 2 (RF2). Normally, during termination, the 3 (RF3), a GTPase, functions downstream of peptide where it accelerates dissociation RF1/RF2 prior to ribosome recycling. addition their canonical function in both classes also involved post peptidyl transfer quality control (post PT QC) mechanism termination factors recognize mismatched (i.e. error-containing) complexes promote premature termination....
// Chelsea E. Cunningham 1, * , Shuangshuang Li Frederick S. Vizeacoumar Kalpana Kalyanasundaram Bhanumathy 1 Joo Sang Lee 2 Sreejit Parameswaran Levi Furber Omar Abuhussein 3 James M. Paul Megan McDonald Shaina D. Templeton Hersh Shukla Amr El Zawily Boyd Nezeka Alli Darrell Mousseau 4 Ron Geyer Keith Bonham 5 Deborah H. Anderson Jiong Yan Li-Yuan Yu-Lee 6 Beth A. Weaver 7 Maruti Uppalapati Eytan Ruppin Anna Sablina 8 Andrew Freywald Franco J. 3, Department of Pathology, Cancer Cluster,...
Abstract Nearly a third of patients with high-grade serous ovarian cancer (HGSC) do not respond to initial therapy and have an overall poor prognosis. However, there are no validated tools that accurately predict which will respond. Our objective is create validate accurate models prediction for treatment response in HGSC. This retrospective case–control study integrates comprehensive clinical genomic data from 88 HGSC single institution. Responders were those progression-free survival at...
Few advances in the treatment of advanced epithelial ovarian cancer have improved patient overall survival. However, incorporation intraperitoneal administration platinum based chemotherapy to standard was one such advancement. It is understood that regimen associated with increased toxicity when compared intravenous alone; however, information regarding specific risk ototoxicity lacking literature. We report a case almost complete sensorineural hearing loss after cycle cisplatin. Three days...
Abstract Purpose We aim to understand if rurality impacts patients’ odds of presenting with stage IV ovarian cancer at diagnosis independent distance primary care provider and the socioeconomic status a patient's residential census tract. Methods A cohort 1,000 women in Iowa, Kansas, Missouri were sampled analyzed from registries’ statewide population data. The sample contained those histologically confirmed 2011‐2012. All variables captured through an extension standard registry protocol...
To determine if there is a difference in overall survival of patients with epithelial ovarian cancer rural, urban, and metropolitan settings the United States.We performed retrospective cohort study using 2004-2016 National Cancer Database (NCDB) data including high low grade, stage I-IV disease. Bivariate analyses used Student's t-test for continuous variables χ2 test dichotomous variables. Kaplan-Meier curves estimated based on location residence, univariate Cox proportional HR assessed...