A5037478520- Pharmaceutical Practices and Patient Outcomes
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Anesthesia and Sedative Agents
- Opioid Use Disorder Treatment
- Geriatric Care and Nursing Homes
- Cancer Risks and Factors
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Atrial Fibrillation Management and Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Healthcare Decision-Making and Restraints
- Medication Adherence and Compliance
- Ovarian cancer diagnosis and treatment
- Mental Health Treatment and Access
- Substance Abuse Treatment and Outcomes
- BRCA gene mutations in cancer
- Cardiac Health and Mental Health
- Anesthesia and Pain Management
- Statistical Methods in Clinical Trials
University of Iowa
2015-2024
Issues Research
2024
Upper Iowa University
2020
Johnson & Johnson (Brazil)
2018
Research Network (United States)
2016
University of Houston
2015
University of South Dakota
2013
Wake Forest University
2013
University of Iowa Health Care
2013
Center for Devices and Radiological Health
2012
Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS and SAA was determined using simple linear regression subjects from study of delirium 201 long-term care facility residents who not included Simple multiple models then used to determine whether could be modified more effectively predict all 297 subjects. In replication analysis, significantly (R2 = .0947, P <...
The Mini-Sentinel is a pilot program that developing methods, tools, resources, policies, and procedures to facilitate the use of routinely collected electronic healthcare data perform active surveillance safety marketed medical products, including drugs, biologics, devices. U.S. Food Drug Administration (FDA) initiated in 2009 as part its Sentinel Initiative, response Congressional mandate FDA Amendments Act 2007. After two years, includes 31 academic private organizations. It has developed...
Explicit measures of potentially inappropriate prescribing, such as the Beers criteria, have been associated with risk for adverse drug events (ADEs). However, no link has established actual prescribing using implicit measures.To determine whether an measure can predict ADE risk.Patients were veterans aged 65 years and older who seen in primary care clinics participated a randomized controlled trial pharmacist-physician collaborative intervention. Inappropriate was determined at baseline,...
PURPOSE This pilot study examined the ability to operationalize collection of real-world data explore potential use end points extracted from diverse health care organizations and assess how these relate similar in clinical trials for immunotherapy-treated advanced non–small-cell lung cancer. PATIENTS AND METHODS Researchers six followed a common protocol using administrative claims electronic records points, including overall survival (rwOS), time next treatment, treatment discontinuation...
Objectives: To measure the prevalence of anticholinergic use cross‐sectionally in patients receiving cholinesterase inhibitors and to describe change anticholinergics upon inception inhibitor treatment. Design: Cross‐sectional cohort studies. Setting: State Iowa. Participants: Iowa Medicaid beneficiaries aged 50 older with a pharmacy claim for during January 1997 through February 2000. Measurements: Anticholinergic was determined all A frequency distribution compiled, emphasis placed on...
To overview the methods used in Mini-Sentinel systematic reviews of validation studies algorithms to identify health outcomes administrative and claims data describe lessons learned development search strategies, including their ability articles from previous which different strategies.Literature searches were conducted using PubMed citation database Iowa Drug Information Service. Embase was searched for some outcomes. The based on a strategy developed by Observational Medical Outcomes...
Background Although sex disparities in the diagnostic evaluation and revascularization of patients with acute myocardial infarction are well documented, no study has evaluated longitudinal trends these disparities. Methods Results Using National Inpatient Sample from 2005 to 2019, 9 259 932 were identified. We divided 15 years into five 3-year periods. The primary objective was evaluate sex-based use angiography, percutaneous coronary intervention, artery bypass graft (CABG) among...
The validity of findings from surveillance activities, which use administrative and claims data to link exposures adverse events, depends in part on the algorithms identify health outcomes using these data. This review provides a high level overview 19 systematic reviews studies, have examined author categorized basis strength evidence supporting valid acute or incident events suggested priorities for future validation studies.The were evaluated, key suggestions research summarized by single...
Delirium is challenging to diagnose in older populations. It often reversible, and when detected, treatment can improve patient outcomes. detection currently relies on trained staff conduct neurocognitive interviews. The Observation Screening Scale (DOS) a screen designed allow faster, easier identification of delirium. In this validation study, conducted at an academic tertiary care center, we attempted determine the accuracy DOS as delirium screening tool hospitalized patients over 64...
Results from studies assessing the association between anticholinergic use and falls are mixed, prior limited in their ability to control for important potential confounders. Thus, we sought examine medication use, including over-the-counter medications, recurrent community-dwelling older women. We analyzed data a prospective cohort study of women aged 65 79 years Women's Health Initiative Observational Study Clinical Trials. Women were recruited 1993 1998, analyses included 61,451 with...
Objectives To examine the risk of community‐acquired pneumonia ( CAP ) associated with use anticholinergic medications in elderly adults. Design Nested case–control study. Setting A regional Medicare Advantage healthcare plan (2009–2010). Participants were Plan enrollees aged 65 and older at least one inpatient outpatient claim no history between January 1 June 30, 2009. Cases identified as an incident diagnosis , July 1, 2009, December 31, 2010 (n = 291). Four age‐ sex‐matched controls...