A5003617528- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- COVID-19 Clinical Research Studies
- Healthcare Policy and Management
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Electronic Health Records Systems
- Clinical practice guidelines implementation
- Pregnancy and Medication Impact
- Sports injuries and prevention
- Data Quality and Management
- Vaccine Coverage and Hesitancy
- Pharmaceutical Economics and Policy
- Primary Care and Health Outcomes
- Long-Term Effects of COVID-19
- Pharmacovigilance and Adverse Drug Reactions
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 and Mental Health
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Qualitative Comparative Analysis Research
- Radiation Dose and Imaging
University of North Carolina at Chapel Hill
1978-2025
IQ Solutions
2018-2024
IQVIA (United States)
2015-2024
IQVIA (United Kingdom)
2012-2023
Deerfield (United States)
2023
Triangle
2019
Health Outcomes Solutions (United States)
2010-2012
Laguna College of Art and Design
2012
Khyber Teaching Hospital
2011
The Royal Free Hospital
2011
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Abstract Objective. To assess the risk of serious liver disease in patients with rheumatoid arthritis (RA) taking methotrexate (MTX). Methods. We surveyed members American College Rheumatology to determine previous use MTX treatment and identify cases cirrhosis failure. Cases were confirmed by review pathology specimens, findings from diagnostic testing, clinical presentations. A case—control study was then conducted ascertain prognostic factors. Case control medical records reviewed for...
Doctors, patients, and other decision makers need access to the best available clinical evidence, which can come from systematic reviews, experimental trials, observational research. Despite methodological challenges, high-quality studies have an important role in comparative effectiveness research because they address issues that are otherwise difficult or impossible study. In addition, many policy decisions do not require very high levels of certainty provided by large, rigorous randomized...
Background. Influenza A(H5N1) continues to cause infections and possesses pandemic potential. Methods. Data sources were primarily clinical records, published case series, governmental agency reports. Cox proportional hazards regression was used estimate the effect of treatment on survival, with adjustment using propensity scores (a composite measure baseline variables predicting use treatment).
Recognizing the growing need for robust evidence about treatment effectiveness in real-world populations, Good Research Comparative Effectiveness (GRACE) guidelines have been developed noninterventional studies of comparative to determine which are sufficiently rigorous be reliable enough use health technology assessments.To evaluate aspects GRACE Checklist contribute most strongly recognition quality.We assembled 28 observational articles published from 2001 2010 that compared and/or safety...
While there is growing demand for information about comparative effectiveness (CE), substantial debate whether and when observational studies have sufficient quality to support decision making.To develop test an item checklist that can be used qualify those CE sufficiently rigorous in design execution contribute meaningfully the evidence base support.An 11-item data methods (the GRACE checklist) was developed through literature review consultation with experts from professional societies,...
PURPOSE This pilot study examined the ability to operationalize collection of real-world data explore potential use end points extracted from diverse health care organizations and assess how these relate similar in clinical trials for immunotherapy-treated advanced non–small-cell lung cancer. PATIENTS AND METHODS Researchers six followed a common protocol using administrative claims electronic records points, including overall survival (rwOS), time next treatment, treatment discontinuation...
Abstract Randomized clinical trials (RCTs) are the gold standard in producing evidence of efficacy and safety medical interventions. More recently, a new paradigm is emerging—specifically within context preauthorization regulatory decision‐making—for some novel uses real‐world (RWE) from variety data (RWD) sources to answer certain questions. Traditionally reserved for rare diseases other special circumstances, external controls (eg, historical controls) recognized as possible type control...
Abstract Objective . To describe the frequency and costs of medical services for patients with osteoarthritis (OA) or rheumatoid arthritis (RA) in a managed care setting. Methods Individual utilization records pharmacy OA RA were obtained from group‐model health maintenance organization (HMO). Estimates made drugs July 1, 1993 to June 30, 1994 using Medicare reimbursement schedules average wholesale drug prices. Calculated rates each population expressed as counts events dollars per...
Epidemiologists are now embarking on the evaluation of hypothesis that exposure to radio frequency energy from lowpower wireless communication devices, such as portable cellular telephones, causes brain cancer and other adverse health outcomes. Even in laboratory, exposures sources difficult quantify; their measurement large populations for epidemiologic study is challenging. In this paper, we outline nature magnitude these discuss prospects obtaining useful measures research.
There is growing interest in regulatory use of randomized pragmatic trials and noninterventional real-world (RW) studies effectiveness safety, but there no agreed-on framework for assessing when this type evidence sufficiently reliable. Rather than impose a clinical trial-like paradigm on RW evidence, like blinded treatments or complete, source-verified data, the utility should be grounded context specific study objectives, events that are likely to detected routine care, extent which...
Background. Oseltamivir is widely used as treatment for influenza virus A subtype H5N1 (hereafter, "H5N1") infection but, like any intervention, not always effective.
ABSTRACT Purpose Ejection fraction (EF) is crucial information when studying the use and effectiveness of therapies in patients with heart failure (HF) myocardial infarction (MI). We aimed to assess validity claims data‐based definitions systolic dysfunction (SD). Methods identified 1072 EF recorded for an HF/MI hospitalization Medicare linked pharmacy data national registries 1999–2006. Thirteen claims‐based SD were developed using a single or combination ICD‐9 diagnosis codes...
Background: Ankle sprains are one of the most common injuries in basketball. Despite this, incidence and setting ankle among elite basketball players not well described. Purpose: To describe epidemiology National Basketball Association (NBA) players. Study Design: Cohort study; Level evidence, 3. Methods: All on an NBA roster for ≥1 game (preseason, regular season, or playoffs) during 2013-14 through 2016-17 seasons were included. Data collected with electronic medical record system. teams...
"Research-ready" evidence platforms that link sports data with anonymized electronic health records (EHRs) or other are important tools for evaluating injury occurrence in response to changes games, training, rules, and factors. While there is agreement high-quality essential, little guide curation.We hypothesized an EHR used the course of clinical care curated research readiness can provide a robust platform. Our purpose was describe curation active surveillance by National Football League...