A5005654647- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Electronic Health Records Systems
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Medical Coding and Health Information
- Machine Learning in Healthcare
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Chronic Disease Management Strategies
- Data Quality and Management
- Biomedical Text Mining and Ontologies
- Artificial Intelligence in Healthcare
- COVID-19 and healthcare impacts
- Clinical practice guidelines implementation
- Healthcare Policy and Management
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Statistical Methods in Clinical Trials
- Pneumonia and Respiratory Infections
- Ethics in Clinical Research
- Hip and Femur Fractures
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
Cornell University
2020-2025
Weill Cornell Medicine
2020-2025
Research Network (United States)
2024-2025
University of Pennsylvania
2006-2024
Louisiana Public Health Institute
2024
Children's Hospital of Philadelphia
1988-2024
University of Iowa
2024
New York University
2014-2024
National Institutes of Health
2024
University of Washington
2024
The growing amount of data in operational electronic health record systems provides unprecedented opportunity for its reuse many tasks, including comparative effectiveness research. However, there are caveats to the use such data. Electronic from clinical settings may be inaccurate, incomplete, transformed ways that undermine their meaning, unrecoverable research, unknown provenance, insufficient granularity, and incompatible with research protocols. quantity real-world nature these provide...
The Mini-Sentinel is a pilot program that developing methods, tools, resources, policies, and procedures to facilitate the use of routinely collected electronic healthcare data perform active surveillance safety marketed medical products, including drugs, biologics, devices. U.S. Food Drug Administration (FDA) initiated in 2009 as part its Sentinel Initiative, response Congressional mandate FDA Amendments Act 2007. After two years, includes 31 academic private organizations. It has developed...
We describe the design, implementation, and use of a large, multiorganizational distributed database developed to support Mini-Sentinel Pilot Program US Food Drug Administration (FDA). As envisioned by FDA, this implementation will inform facilitate development an active surveillance system for monitoring safety medical products (drugs, biologics, devices) in USA.A common data model was designed address priorities leverage experience participating organizations partners. A review existing...
Abstract The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum symptoms and signs that are persistent, exacerbated or newly incident in the period after acute infection. Most studies have examined these conditions individually without providing evidence on co-occurring conditions. In this study, we leveraged electronic health record data two large cohorts, INSIGHT OneFlorida+, from national Patient-Centered Clinical Research Network. We created development cohort...
The COVID-19 pandemic has magnified longstanding health care and social inequities, resulting in disproportionately high COVID-19-associated illness death among members of racial ethnic minority groups (1). Equitable use effective medications (2) could reduce disparities these severe outcomes (3). Monoclonal antibody (mAb) therapies against SARS-CoV-2, the virus that causes COVID-19, initially received Emergency Use Authorization (EUA) from Food Drug Administration (FDA) November 2020. mAbs...
Abstract Background Compared to white individuals, Black and Hispanic individuals have higher rates of COVID-19 hospitalization death. Less is known about racial/ethnic differences in post-acute sequelae SARS-CoV-2 infection (PASC). Objective Examine potential PASC symptoms conditions among hospitalized non-hospitalized patients. Design Retrospective cohort study using data from electronic health records. Participants 62,339 patients with 247,881 without New York City between March 2020...
Recent studies have investigated post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) using real-world patient data such as electronic health records (EHR). Prior typically been conducted on cohorts with specific populations which makes their generalizability unclear. This study aims to characterize PASC the EHR warehouses from two large Patient-Centered Clinical Research Networks (PCORnet), INSIGHT and OneFlorida+, include 11 million patients in New York City (NYC) area 16.8...
Inappropriate use of antimicrobial agents results in unnecessary exposure to medication, persistent or progressive infection, emergence resistance, and increased costs. We implemented a program control restricted while improving care. This study compared 2 major mechanisms for agents: (1) recommendations made by the Antimicrobial Management Team (AMT), which included clinical pharmacist backed up physician from Division Infectious Diseases (ID), (2) ID fellows. Outcome measures...
Financial incentives to physicians or patients are increasingly used, but their effectiveness is not well established.To determine whether physician financial incentives, patient shared and more effective than control in reducing levels of low-density lipoprotein cholesterol (LDL-C) among with high cardiovascular risk.Four-group, multicenter, cluster randomized clinical trial a 12-month intervention conducted from 2011 2014 3 primary care practices the northeastern United States. Three...
PURPOSE: Use of administrative or population-based databases for post-marketing pharmacoepidemiology research in patients with end-stage liver disease (ESLD) has been limited by the difficulty accurately identifying such patients. Algorithms to identify ESLD using ICD-9-CM codes have not developed outside Veterans Affairs healthcare setting. METHODS: We queried electronic medical records at two tertiary care hospitals indicative ESLD. Coding algorithms were confirmed ESLD, and these tested...
<b>PURPOSE</b> Racial disparities in treating pain with opioids are widely reported; however, differences use of recommended strategies to reduce the risk opioid misuse by race/ethnicity have not been evaluated. <b>METHODS</b> In a retrospective cohort black and white patients chronic noncancer prescribed analgesics for at least 3 months, we assessed physicians’ reduction strategies: (1) urine drug testing, (2) regular office visits (at 1 visit per 6 months on within 30 days an change), (3)...
Our goal is to summarize the collective experience of 15 organizations in dealing with uncoordinated efforts that result unnecessary delays understanding, predicting, preparing for, containing, and mitigating COVID-19 pandemic US. Response involve collection analysis data corresponding healthcare organizations, public health departments, socioeconomic indicators, as well additional signals collected directly from individuals communities. We focused on electronic record (EHR) data, since EHRs...
Abstract Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods the impact preexisting on probable PASC in adults and children using electronic health record data from multiple research networks. Three networks within REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, National Cohort...
Abstract Background SARS-CoV-2-infected patients may develop new conditions in the period after acute infection. These conditions, post-acute sequelae of SARS-CoV-2 infection (PASC, or Long COVID), involve a diverse set organ systems. Limited studies have investigated predictability COVID development and its associated risk factors. Methods In this retrospective cohort study, we used electronic healthcare records from two large-scale PCORnet clinical research networks, INSIGHT (~1.4 million...
Abstract Background Integrating artificial intelligence (AI) in healthcare settings has the potential to benefit clinical decision-making. Addressing challenges such as ensuring trustworthiness, mitigating bias, and maintaining safety is paramount. The lack of established methodologies for pre- post-deployment evaluation AI tools regarding crucial attributes transparency, performance monitoring, adverse event reporting makes this situation challenging. Objectives This paper aims make...
Incidence estimates of post-acute sequelae SARS-CoV-2 infection, also known as long-COVID, have varied across studies and changed over time. We estimated long-COVID incidence among adult pediatric populations in three nationwide research networks electronic health records (EHR) participating the RECOVER Initiative using different classification algorithms (computable phenotypes). This EHR-based retrospective cohort study included patients with documented acute infection two control groups--...
To identify risk factors for infection with imipenem-resistant Pseudomonas aeruginosa and determine the impact of imipenem resistance on clinical economic outcomes among patients infected P. aeruginosa.An ecologic study, a case-control retrospective cohort study.A 625-bed tertiary care medical center.All who had an inpatient culture positive between January 1, 1999, December 31, 2000.From 1991 through 2000, annual prevalence isolates increased significantly (P<.001 by chi (2) test trend)....
Abstract Objectives: Serum lactate values in the emergency department (ED) have been associated with mortality diverse populations of critically ill patients. This study investigates whether serum measured ED are older patients admitted to hospital, both and without infections. Methods: is a retrospective cohort performed at two urban teaching hospitals. The population includes 1,655 (age ≥ 65 years) over 3‐year period (2004–2006) who had prior admission. presence or absence infection was...
Pseudomonas aeruginosa is one of the most common gram-negative hospital-acquired pathogens. Resistance this organism to imipenem complicates treatment.To elucidate risk factors for imipenem-resistant P. (IRPA) infection or colonization and identify effect resistance on clinical economic outcomes.Longitudinal trends in prevalence IRPA from 2 centers were characterized during period 1989 through 2006. For isolates obtained 2001 2006, a case-control study was conducted investigate association...
Acinetobacter baumannii is an emerging gram-negative pathogen that can cause healthcare-acquired infections among patients. Treatment complicated for cases of infection with A. resistant to imipenem.To elucidate the risk factors imipenem-resistant (IRAB) or colonization and identify effect resistance on clinical economic outcomes.We analyzed data from 2 medical centers University Pennsylvania. Longitudinal trends in prevalence IRAB isolates were characterized during period 1989 through 2004....