A5085983888- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- COVID-19 Impact on Reproduction
- Vitamin C and Antioxidants Research
- Machine Learning in Healthcare
- COVID-19 and healthcare impacts
- Chronic Disease Management Strategies
- Pregnancy and Medication Impact
- Diabetes Management and Research
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Antimicrobial Resistance in Staphylococcus
- Dialysis and Renal Disease Management
- Pregnancy and preeclampsia studies
- Hepatitis C virus research
- Food Security and Health in Diverse Populations
- Metabolism, Diabetes, and Cancer
- Electrolyte and hormonal disorders
National Institutes of Health
2014-2025
Uniformed Services University of the Health Sciences
2011-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2015-2025
Office of the Director
2016-2025
Office of the Director
2020-2021
Henry M. Jackson Foundation
2016
Stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, COVID is incompletely understood and characterised by a wide range manifestations that are difficult to analyse computationally. Additionally, the generalisability machine learning classification COVID-19 outcomes has rarely been tested.
INTRODUCTION. The clinical course of coronavirus 2019 (COVID-19) is heterogeneous, ranging from mild to severe multiorgan failure and death. In this study, we analyzed cell-free DNA (cfDNA) as a biomarker injury define the sources tissue that contribute such different trajectories.
Glucagon, a hormone released from pancreatic α cells, plays key role in maintaining proper glucose homeostasis and has been implicated the pathophysiology of diabetes. In vitro studies suggest that intraislet glucagon can modulate function β cells. However, because lack suitable experimental tools, vivo physiological this cross-talk remained elusive. To address issue, we generated mouse model selectively expressed an inhibitory designer GPCR (Gi DREADD) cells only. Drug-induced activation...
Background: Continued assessment of casualty complications, such as infections, enables the development evidence-based guidelines to mitigate excess morbidity and mortality. We examine Joint Theater Trauma Registry (JTTR) for infections potential risk factors, transfusions, among Iraq Afghanistan trauma patients. Methods: JTTR entries from deployment-related injuries with completed records between March 19, 2003, April 13, 2009, were evaluated using International Classification Diseases-9...
Chronic kidney disease (CKD) is associated with persistent low-grade inflammation and immunosuppression. In this study we tested the role of Toll-like receptor 4, main for endotoxin (LPS), in a mouse model renal fibrosis progressive CKD that better resembles human disease. C3HeJ (TLR4 mutant) mice have missense point mutation TLR4 gene, rendering nonfunctional. after folic acid injection, mutant developed less interstititial comparison to wild-type (WT) mice. Furthermore, 4 weeks 5/6...
Healthcare datasets obtained from Electronic Health Records have proven to be extremely useful for assessing associations between patients' predictors and outcomes of interest. However, these often suffer missing values in a high proportion cases, whose removal may introduce severe bias. Several multiple imputation algorithms been proposed attempt recover the information under an assumed missingness mechanism. Each algorithm presents strengths weaknesses, there is currently no consensus on...
Infections are a common acute and chronic complication of combat-related injuries; however, no systematic attempt to assess infections associated with US injuries occurring in Iraq Afghanistan has been conducted. The Joint Theater Trauma Registry (JTTR) established collect injury specific medical data from casualties Afghanistan.We reviewed the JTTR for identification infectious complications (IC) using International Classification Diseases, 9th Revision (ICD-9) coding during two phases...
Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability human immunodeficiency (HIV)–infected adults.
Background: In recent years, invasive fungal infections (IFI) have complicated the clinical course of patients with combat-related injuries. Commonalities in injury patterns and characteristics among IFI led to development a Joint Trauma System (JTS) practice guideline (CPG) for management. We performed case-control study confirm further delineate risk factors associated combat casualties objective generating data refine CPG promote timelier initiation treatment. Methods: Data were collected...
Summary Background Serum fibrosis markers are useful in staging chronic hepatitis B ( HBV ) and C HCV virus but have not been evaluated D HDV ). Aim To evaluate the utility of serum [fibrosis‐4 score FIB ‐4), aspartate aminotransferase AST to alanine ALT ratio, ratio AAR ), age‐platelet index API ‐to‐platelet‐ratio‐index APRI Hui score] infection. Methods Clinical histologic laboratory data from , patients were calculated. The ability detect advanced (Ishak ≥4) cirrhosis = 6) compared...
There is broad consensus that high grade basal proteinuria and failure to achieve remission of are key determinants adverse renal prognosis in patients with primary membranous nephropathy. Based on the fact current regimens not ideal due short long-term toxicity propensity relapse after treatment withdrawal, we developed a protocol based novel combination rituximab cyclosporine which targets both B T cell limbs immune system. Herein, report pilot study data proteinuria, changes autoantibody...
The Fragile X-related disorders (FXDs) are Repeat Expansion Diseases resulting from an expansion of a CGG-repeat tract at the 5' end FMR1 gene. mechanism responsible for this unusual mutation is not fully understood. We have previously shown that mismatch repair (MMR) complexes, MSH2/MSH3 (MutSβ) and MSH2/MSH6 (MutSα), together with Polβ, DNA polymerase important base excision (BER), expansions in mouse model these disorders. Here we show MLH1/MLH3 (MutLγ), protein complex can act downstream...
Abstract Accurate stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, the natural history COVID is incompletely understood and characterized by an extremely wide range manifestations that are difficult to analyze computationally. In addition, generalizability machine learning classification COVID-19 outcomes has rarely been tested. We present a method for computationally modeling PASC...
OBJECTIVE The purpose of the study is to evaluate relationship between HbA1c and severity coronavirus disease 2019 (COVID-19) outcomes in patients with type 2 diabetes (T2D) acute COVID-19 infection. RESEARCH DESIGN AND METHODS We conducted a retrospective using observational data from National COVID Cohort Collaborative (N3C), longitudinal, multicenter U.S. cohort Patients were ≥18 years old T2D confirmed infection by laboratory testing or diagnosis code. primary outcome was 30-day...
Background Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients Coronavirus Disease 2019 (COVID-19) who are at risk progression to severe disease due the presence of one or more factors. Millions treatment courses have been prescribed in United States alone. Paxlovid was highly effective preventing hospitalization and death clinical trials. Several studies found a protective association real-world data, but they variously used less recent study periods, correlational methods,...
In this prospective cluster-randomized trial among high-risk military trainees, personal hygiene and education measures, including once-weekly use of chlorhexidine body wash, did not prevent overall skin soft tissue infection (SSTI) or methicillin-resistant Staphylococcus aureus SSTI. Background. Effective measures are needed to (MRSA) infections (SSTIs) in community settings. The study objective was evaluate the effect hygiene–based strategies on rates SSTI MRSA Methods. We conducted a...
Diabetes is associated with low plasma vitamin C concentrations. We investigated the contribution of dysregulated renal physiology, its prevalence, and clinical characteristics. An essential prerequisite was determination normal threshold, concentration at which first appears in urine. Using data from 17 healthy participants who underwent depletion–repletion studies a dose range 15–1250 mg daily, threshold estimated using physiology-based pharmacokinetics modeling. Applying 95% CIs, we...
Abstract Background Multi-institution electronic health records (EHR) are a rich source of real world data (RWD) for generating evidence (RWE) regarding the utilization, benefits and harms medical interventions. They provide access to clinical from large pooled patient populations in addition laboratory measurements unavailable insurance claims-based data. However, secondary use these research requires specialized knowledge careful evaluation quality completeness. We discuss assessments...