A5007145512- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pharmaceutical Practices and Patient Outcomes
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Healthcare cost, quality, practices
- Dementia and Cognitive Impairment Research
- Atrial Fibrillation Management and Outcomes
- Urological Disorders and Treatments
- Medication Adherence and Compliance
- Pancreatitis Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Geriatric Care and Nursing Homes
- Cancer survivorship and care
- Pharmacology and Obesity Treatment
Johns Hopkins University
2020-2025
Collaborative Research Group
2024
Cohort (United Kingdom)
2024
Sawai Man Singh Hospital
2024
George Washington University
2021
Johns Hopkins Medicine
2020-2021
Milken Institute
2020-2021
Institute for Safe Medication Practices
2020-2021
HCA Healthcare
2021
Bloomberg (United States)
2021
Stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, COVID is incompletely understood and characterised by a wide range manifestations that are difficult to analyse computationally. Additionally, the generalisability machine learning classification COVID-19 outcomes has rarely been tested.
Nursing home residents account for approximately 40% of deaths from SARS-CoV-2.To identify risk factors SARS-CoV-2 incidence, hospitalization, and mortality among nursing in the US.This retrospective longitudinal cohort study was conducted long-stay aged 65 years or older with fee-for-service Medicare residing 15 038 US homes April 1, 2020, to September 30, 2020. Data were analyzed November 22, February 10, 2021.The main outcome diagnosis (per International Statistical Classification...
Radical cystectomy is the guidelines-recommended treatment of muscle-invasive bladder cancer, but a resurgence trimodal therapy has occurred. Limited comparative data are available on outcomes and costs attributable to these 2 treatments.To compare survival between radical in older adults with cancer.This population-based cohort study used from Surveillance, Epidemiology, End Results-Medicare linked database. A total 3200 (aged ≥66 years) clinical stage T2 T4a cancer diagnosed January 1,...
Background The concomitant use of tyrosine kinase inhibitors (TKIs) and proton pump (PPIs) is a significant concern because potential drug‐drug interaction that reduces TKI absorption, thus potentially reducing the effectiveness TKIs. objective this study was to evaluate prevalence predictors TKI‐PPI receipt its impact on survival therapy discontinuation in older adults with cancer. Methods This retrospective used linked Surveillance, Epidemiology, End Results‐Medicare data for years 2007...
Many individuals take long-term immunosuppressive medications. We evaluated whether these have worse outcomes when hospitalised with COVID-19 compared non-immunosuppressed individuals.
Abstract Background It is unclear whether chronic use of immunosuppressive drugs worsens or improves the severity coronavirus disease 2019 (COVID-19), with plausible mechanisms for both. Methods Retrospective cohort study in 2121 consecutive adults acute inpatient hospital admission between 4 March and 29 August 2020 confirmed suspected COVID-19 a large academic health system, adjustment confounding propensity score–derived stabilized inverse probability treatment weights. Chronic...
The increased hospital mortality rates from non-SARS-CoV-2 causes during the SARS-CoV-2 pandemic are incompletely characterized.
OBJECTIVE To determine the respective associations of premorbid glucagon-like peptide-1 receptor agonist (GLP1-RA) and sodium–glucose cotransporter 2 inhibitor (SGLT2i) use, compared with dipeptidyl peptidase 4 (DPP4i) severity outcomes in setting severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. RESEARCH DESIGN AND METHODS We analyzed observational data from SARS-CoV-2–positive adults National COVID Cohort Collaborative (N3C), a multicenter, longitudinal U.S. cohort...
There is an urgent need to understand the real-world effectiveness of remdesivir in treatment severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).This was a retrospective comparative study. Individuals hospitalized large private healthcare network United States from 23 February 2020 through 11 2021 with positive test for SARS-CoV-2 and ICD-10 diagnosis codes consistent symptomatic disease 2019 (COVID-19) were included. Remdesivir recipients matched controls using time-dependent...
Abstract Background More than one-third of individuals experience post-acute sequelae SARS-CoV-2 infection (PASC, which includes long-COVID). The objective is to identify risk factors associated with PASC/long-COVID diagnosis. Methods This was a retrospective case–control study including 31 health systems in the United States from National COVID Cohort Collaborative (N3C). 8,325 PASC (defined by presence International Classification Diseases, version 10 code U09.9 or long-COVID clinic visit)...
Introduction: The optimal methodology for assessing comorbidity to predict various surgical outcomes such as mortality, readmissions, complications, and failure rescue (FTR) using claims data has not been established. Objective: Compare diagnosis-based prescription-based scores predicting outcomes. Methods: We used 100% Texas Medicare (2006–2011) included patients undergoing coronary artery bypass grafting, pulmonary lobectomy, endovascular repair of abdominal aortic aneurysm, open...
Background: For pancreatectomy patients, mortality increases with increasing age. Our study evaluated the relative contribution of overall postoperative complications and failure to rescue rates on observed increased in older patients undergoing pancreatic resection at specialized centers. Methods: We identified 2694 who underwent from American College Surgeons’ National Surgical Quality Improvement Pancreatectomy Demonstration Project 37 high-volume Overall morbidity in-hospital were...
This study investigated cost-related medication nonadherence among survivors of adolescent and young adult cancer a comparison group in the United States.A cross-sectional analysis 2013 to 2015 National Health Interview Survey was performed. N=953 patients who were diagnosed with between ages 15 39 years identified, created using propensity scores. Cost-related determined by individuals' report skipping medication, taking less or delaying filling save money previous year. Covariates included...
BACKGROUND This study was designed to adapt the Elixhauser comorbidity index for 4 cancer‐specific populations (breast, prostate, lung, and colorectal) compare 3 versions of score (individual comorbidities, summary score, score) with Charlson predicting 2‐year survival types cancer. METHODS cohort used Texas Cancer Registry–linked Medicare data from 2005 2011 older patients diagnosed breast (n = 19,082), prostate 23,044), lung 26,047), or colorectal cancer 16,693). For each cohort, were...
Studies have found conflicting evidence regarding the association of hypoglycemia with dementia. We evaluated an subsequent dementia in patients type 2 diabetes. This retrospective longitudinal cohort study used Clinical Practice Research Datalink, electronic medical records data from United Kingdom, 2003 to 2012. included aged >65 years diagnosed diabetes, no prior diagnosis Dementia was defined using codes records. All were followed date initial diabetes diagnosis. To account for competing...
Objectives The coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed characterise registered clinical trials assessing drugs or plasma treatments for COVID-19. Design, setting participants Cross-sectional analysis of the treatment COVID-19 that were in USA countries contributing WHO’s International Clinical Trials Registry Platform. Relevant trial entries...
Background: Older adults have many comorbidities contributing to mortality. Objective: To develop a summary Elixhauser (S-Elixhauser) comorbidity score predict 30-day, in-hospital, and 1-year mortality in older using the 38 operationalized by Agency for Healthcare Research Quality (AHRQ). Design: Retrospective cohort study. Setting: Medicare beneficiaries from 2017 2019. Patients: Persons hospitalized 2018 (n = 899 844) 3 disease-specific cohorts. Measurements: Weights were derived The...
OBJECTIVES: COVID-19 treatment guidelines recommend baricitinib or tocilizumab for the management of hospitalized patients with COVID-19. We compared effectiveness vs. on mortality and clinical outcomes among DESIGN: Multicenter, retrospective, propensity-weighted cohort study using a target trial emulation approach. SETTING: The National COVID Cohort Collaborative (N3C), which is largest electronic health records data in United States. setting included 75 hospitals. PATIENTS: Adults who...
Background Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients Coronavirus Disease 2019 (COVID-19) who are at risk progression to severe disease due the presence of one or more factors. Millions treatment courses have been prescribed in United States alone. Paxlovid was highly effective preventing hospitalization and death clinical trials. Several studies found a protective association real-world data, but they variously used less recent study periods, correlational methods,...