A5051075619- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Bariatric Surgery and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Physical Activity and Health
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- COVID-19 and Mental Health
- Autoimmune and Inflammatory Disorders Research
- Venous Thromboembolism Diagnosis and Management
- Obesity, Physical Activity, Diet
- Spondyloarthritis Studies and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 epidemiological studies
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Psoriasis: Treatment and Pathogenesis
- Atrial Fibrillation Management and Outcomes
- Multiple Sclerosis Research Studies
- Statistical Methods in Clinical Trials
- Vaccine Coverage and Hesitancy
Pfizer (United States)
2022-2025
Johns Hopkins University
2019-2024
American Society of Safety Professionals
2023
Johns Hopkins Medicine
2021
National Heart Lung and Blood Institute
2021
National Institute on Aging
2021
HCA Healthcare
2021
National Center for Advancing Translational Sciences
2021
National Institutes of Health
2021
Weatherford College
2021
In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.
To examine whether initiation of interleukin (IL)-17, IL-12/23 or tumour necrosis factor (TNF) inhibitor is associated with an increased risk serious infection among real-world psoriasis (PsO) psoriatic arthritis (PsA) patients.
Many individuals take long-term immunosuppressive medications. We evaluated whether these have worse outcomes when hospitalised with COVID-19 compared non-immunosuppressed individuals.
Abstract Background It is unclear whether chronic use of immunosuppressive drugs worsens or improves the severity coronavirus disease 2019 (COVID-19), with plausible mechanisms for both. Methods Retrospective cohort study in 2121 consecutive adults acute inpatient hospital admission between 4 March and 29 August 2020 confirmed suspected COVID-19 a large academic health system, adjustment confounding propensity score–derived stabilized inverse probability treatment weights. Chronic...
There is an urgent need to understand the real-world effectiveness of remdesivir in treatment severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).This was a retrospective comparative study. Individuals hospitalized large private healthcare network United States from 23 February 2020 through 11 2021 with positive test for SARS-CoV-2 and ICD-10 diagnosis codes consistent symptomatic disease 2019 (COVID-19) were included. Remdesivir recipients matched controls using time-dependent...
ABSTRACT Background Individuals with immune dysfunction, including people HIV (PWH) or solid organ transplant recipients (SOT), might have worse outcomes from COVID-19. We compared odds of COVID-19 between patients and without dysfunction. Methods evaluated data the National Cohort Collaborative (N3C), a multicenter retrospective cohort electronic medical record (EMR) across United States, on. 1,446,913 adult laboratory-confirmed SARS-CoV-2 infection. HIV, SOT, comorbidity, markers were...
Objective Describe the economic burden of COVID-19 on employers and employees in United States (US).
AbstractThis investigation characterized the symptom patterns and mental status changes precipitated by anabolic steroid abuse. Twenty male weightlifters who were currently using steroids compared to 20 had never used steroids. The users significantly (p < 0.005) more somatic, depressive, anxiety, hostility, paranoid complaints when than they not drugs. When contrasted weightlifter controls, a greater number of depression, hostility during cycles use. However, no differences in frequency...
Objective To create case definitions for confirmed COVID-19 diagnoses, vaccination status and three separate of high risk severe COVID-19, as well to assess whether the implementation these in a cohort reflected sociodemographic clinical characteristics epidemiology England. Design Retrospective study. Setting Electronic healthcare records from primary care (Clinical Practice Research Datalink, CPRD) linked secondary data (Hospital Episode Statistics) covering 24% population Participants 2...
Abstract Background Immunocompromised individuals experience a disproportionate burden of COVID-19-associated hospitalization and death. COVID-19 vaccine uptake has declined over time. We evaluated XBB.1.5-adapted uptake, regardless brand, during the 2023-2024 season among immunocompromised persons using data from two large state registries. Methods Individuals with continuous pharmacy medical enrollment (≥6 months for children &lt; 18 years, ≥12 adults ≥18 years) in insurance plans...
Abstract Background Prior to May 11, 2023, all COVID-19 vaccinations were required be reported by states the Centers for Disease Control and Prevention. In post-pandemic era, national vaccination uptake is now estimated using National Immunization Survey (NIS). While survey methodology attempts achieve random sampling of population accurate assessment vaccine use through self-report, it unknown how these estimates compare state registries. We aimed during 2023-2024 season from registries...
Abstract Background COVID-19 disease severity has fluctuated with emergence of variants. To investigate in children, we analyzed clinical resource utilization among children hospitalized for during different variant periods the United States. Methods We constructed a cohort age &lt; 5 years (ICD-10-CM code U07.1 “COVID-19”) using PINC AI Healthcare Data, hospital-based real world data source from Hospitalizations pre-Delta (April - June 2021), Delta (July December 2021) or Omicron...
Long COVID, a diverse set of symptoms that persist after minimum 4 weeks from the initial SARS-CoV-2 infection, has posed substantial burden to healthcare systems. There is some evidence COVID-19 vaccination may be associated with lower risk long COVID. However, little known about association between status and COVID-associated resource utilisation (HCRU) costs. We conducted cohort study using primary care electronic health record data in England Clinical Practice Research Datalink (CPRD)...
Obesity is implicated in rheumatoid arthritis (RA) development, severity, outcomes, and treatment response. We estimated the independent effects of overweight obesity on ability to achieve sustained remission (sREM) 3 years following RA diagnosis.Data were from Canadian Early Arthritis Cohort, a multicenter observational trial early patients treated by rheumatologists using guideline-based care. sREM was defined as Disease Activity Score 28 joints (DAS28) <2.6 for 2 consecutive visits....
Relatively little is known about the use patterns of potential pharmacologic treatments COVID-19 in United States.To National COVID Cohort Collaborative (N3C), a large, multicenter, longitudinal cohort, to characterize hydroxychloroquine, remdesivir, and dexamethasone, overall as well across individuals, health systems, time.Retrospective cohort study.43 systems States.137 870 adults hospitalized with between 1 February 2020 28 2021.Inpatient or dexamethasone.Among 137 persons confirmed...
Little is known about the relationship between coronavirus disease 2019 (COVID-19) severity and subsequent risk of experiencing a cardiovascular event (CVE) after COVID-19 recovery. We evaluated this in large cohort United States adults.
Objective Rheumatoid arthritis (RA) is chronic, painful, disabling condition resulting in significant impairments physical, emotional, and social health. Our objective was to use different methods perspectives evaluate the responsiveness of Patient‐Reported Outcomes Measurement Information System (PROMIS) short forms (SFs) identify minimal meaningful score changes. Methods Adults with RA who were enrolled a multisite prospective observational cohort completed PROMIS physical function, pain...
Objective To create a data-driven definition of post-COVID conditions (PCC) by directly measure changes in symptomatology before and after first COVID episode. Materials methods Retrospective cohort study using Optum® de-identified Electronic Health Record (EHR) dataset from the United States persons any age April 2020-September 2021. For each person with (ICD-10-CM U07.1 “COVID-19” or positive test result), we selected up to 3 comparators. The final symptom score was computed as sum new...
To quantify direct costs and healthcare resource utilisation (HCRU) associated with acute COVID-19 in adults England.
To describe patterns of glucocorticoid use in a large real-world cohort with early rheumatoid arthritis (RA) and assess the impact on disease activity treatment.Data are from adults new RA (≤1 year) recruited to Canadian Early Arthritis Cohort (CATCH) stratified basis whether person was prescribed oral glucocorticoids within 3 months study entry. Disease compared over 24 months. Mixed-effects logistic regression used for adjusted odds ratios (aORs) escalation biologics separately 12 months,...