A5086498395- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Machine Learning in Healthcare
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Diabetes Management and Research
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Topic Modeling
- Spectral Theory in Mathematical Physics
- Medication Adherence and Compliance
- Acute Myeloid Leukemia Research
- Opioid Use Disorder Treatment
- Sexual function and dysfunction studies
- Advanced Mathematical Modeling in Engineering
- Health, Environment, Cognitive Aging
- Healthcare professionals’ stress and burnout
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Artificial Intelligence in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Hospital Admissions and Outcomes
Stony Brook University
2022-2025
Stony Brook School
2022-2025
National University Cancer Institute, Singapore
2025
National University Hospital
2025
University of Manitoba
1979-2024
Stony Brook University Hospital
2018-2023
BC Cancer Agency
2018-2022
State University of New York
2022
ORCID
2022
Simon Fraser University
2019
Stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, COVID is incompletely understood and characterised by a wide range manifestations that are difficult to analyse computationally. Additionally, the generalisability machine learning classification COVID-19 outcomes has rarely been tested.
Abstract Background Naming a newly discovered disease is difficult process; in the context of COVID-19 pandemic and existence post-acute sequelae SARS-CoV-2 infection (PASC), which includes long COVID, it has proven especially challenging. Disease definitions assignment diagnosis code are often asynchronous iterative. The clinical definition our understanding underlying mechanisms COVID still flux, deployment an ICD-10-CM for USA took nearly 2 years after patients had begun to describe their...
Although the COVID-19 pandemic has persisted for over 3 years, reinfections with SARS-CoV-2 are not well understood. We aim to characterize reinfection, understand development of Long COVID after and compare severity reinfection initial infection.
Healthcare datasets obtained from Electronic Health Records have proven to be extremely useful for assessing associations between patients' predictors and outcomes of interest. However, these often suffer missing values in a high proportion cases, whose removal may introduce severe bias. Several multiple imputation algorithms been proposed attempt recover the information under an assumed missingness mechanism. Each algorithm presents strengths weaknesses, there is currently no consensus on...
Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use electronic health record (EHR)-based study cohort from National COVID Cohort Collaborative (N3C) as part of NIH Researching to Enhance Recovery (RECOVER) Initiative characterize reinfection, understand development Long after and compare severity reinfection initial infection. validate previous findings incidence (5.9%), occurrence most during Omicron epoch, evidence...
OBJECTIVE The purpose of the study is to evaluate relationship between HbA1c and severity coronavirus disease 2019 (COVID-19) outcomes in patients with type 2 diabetes (T2D) acute COVID-19 infection. RESEARCH DESIGN AND METHODS We conducted a retrospective using observational data from National COVID Cohort Collaborative (N3C), longitudinal, multicenter U.S. cohort Patients were ≥18 years old T2D confirmed infection by laboratory testing or diagnosis code. primary outcome was 30-day...
Naming a newly discovered disease is difficult process; in the context of COVID-19 pandemic and existence post-acute sequelae SARS-CoV-2 infection (PASC), which includes Long COVID, it has proven especially challenging. Disease definitions assignment diagnosis code are often asynchronous iterative. The clinical definition our understanding underlying mechanisms COVID still flux, deployment an ICD-10-CM for US took nearly two years after patients had begun to describe their condition. Here we...
Abstract Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk transformation to more aggressive histology over time. Recurrent mutations associated have been identified; however, prognostic features that can be discerned at diagnosis could clinically useful. We present here comprehensive profiling both tumor and immune compartments in 155 diagnostic FL biopsies single-cell resolution by mass cytometry. This revealed a diversity phenotypes included two...
Deep-learning-based clinical decision support using structured electronic health records (EHR) has been an active research area for predicting risks of mortality and diseases. Meanwhile, large amounts narrative notes provide complementary information, but are often not integrated into predictive models. In this paper, we a novel multimodal transformer to fuse EHR data better prediction in-hospital mortality. To improve interpretability, propose gradients (IG) method select important words in...
Abstract Objective Clinical encounter data are heterogeneous and vary greatly from institution to institution. These problems of variance affect interpretability usability clinical for analysis. magnified when multisite electronic health record (EHR) networked together. This article presents a novel, generalizable method resolving heterogeneity analysis by combining related atomic encounters into composite “macrovisits.” Materials Methods Encounters were composed 75 partner sites harmonized...
Introduction Elevated glycosylated hemoglobin (HbA1c) in individuals with type 2 diabetes is associated increased risk of hospitalization and death after acute COVID-19, however the effect HbA1c on Long COVID unclear. Objective Evaluate association glycemic control development patients (T2D). Research design methods We conducted a retrospective cohort study using electronic health record data from National Cohort Collaborative. Our included T2D eight sites longitudinal natural language...
Scalp cooling is standard-of-care for prevention of chemotherapy-induced alopecia (CIA), with proven safety and efficacy. Limb cryotherapy has shown promise in preventing peripheral neuropathy (CIPN). The safe application concomitant scalp limb cryotherapies during chemotherapy crucial due to concerns about potential interactions, including central hypothermia, yet limited data exist on their delivery this context. Here we report a prospective, single-arm study assessing feasibility, safety,...
Studies show metformin use before and during SARS-CoV-2 infection reduces severe COVID-19 postacute sequelae of (PASC) in adults. Our objective was to describe the incidence PASC possible associations with prevalent adults type 2 diabetes mellitus (T2DM).
Despite increasing use of telehealth, there are limited published curricula training primary care providers in utilizing telehealth to deliver complex interdisciplinary care.To describe and evaluate a curriculum with longitudinal objective structured clinical examination (OSCE) improve internal medicine residents' confidence skills coordinating via televisits, electronic consultation, teleconferencing.In 2019, 56 first- third-year residents participated 3-part, 5-week OSCE them manage care....
Residents graduate from medical school with increasing levels of debt and also may possess poor financial knowledge practices. Prior studies have assessed resident interest in education, yet additional information regarding their attitudes about personal finance planning could be essential for the development relevant curricula.We baseline behaviors internal medicine medicine-pediatrics residents 3 geographically diverse academic programs.A modified version Financial Industry Regulatory...
Problem Graduate medical education programs and national organizations are becoming more involved in promoting trainee financial wellness. Current literature reports residents have poor knowledge, high debt levels, low concern about their finances, deficits preparedness, but there has been little published on best practices for implementing wellness or measuring meaningful outcomes of such programs. Approach From June 2017 to 2019, the authors invited 277 internal medicine from Stony Brook...
Background: Sepsis secondary to obstructive uropathy is a urological emergency that requires urgent decompression using placement of percutaneous nephrostomy tube (PCN) or retrograde ureteric stent (RUS). Whether selection PCN RUS impacts mortality remains uncertain. Methods: We conducted retrospective cohort analysis the 2006–2014 Nationwide Inpatient Sample (NIS) 34,009 patients with sepsis and who were treated PCN. The primary outcome was in-hospital mortality. Secondary outcomes included...
Abstract Mechanistic studies in human cancer have relied heavily on cell lines and mouse models, but are limited by vitro adaptation species context issues, respectively. More recent efforts utilized patient-derived xenografts; however, these hampered variable genetic background, inability to study early events, practical issues with availability/reproducibility. We report here an efficient, reproducible model of T-cell leukemia which lentiviral transduction normal cord blood yields...
Identifying consumer health informatics (CHI) literature is challenging. To recommend strategies to improve discoverability, we aimed characterize controlled vocabulary and author terminology applied a subset of CHI on wearable technologies.