A5022901549- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Kawasaki Disease and Coronary Complications
- Diabetes Management and Research
- Machine Learning in Healthcare
- Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Viral Infections and Vectors
- Clinical Laboratory Practices and Quality Control
- Cervical Cancer and HPV Research
- CNS Lymphoma Diagnosis and Treatment
- Genital Health and Disease
- Sepsis Diagnosis and Treatment
- Vector-Borne Animal Diseases
- Autopsy Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Healthcare cost, quality, practices
- Diabetes and associated disorders
- Chronic Disease Management Strategies
- Colorectal and Anal Carcinomas
- COVID-19 diagnosis using AI
University of Arkansas for Medical Sciences
2023-2024
Stony Brook University
2021-2022
The University of Texas Medical Branch at Galveston
2018
The National COVID Cohort Collaborative (N3C) is a centralized, harmonized, high-granularity electronic health record repository that the largest, most representative COVID-19 cohort to date. This multicenter data set can support robust evidence-based development of predictive and diagnostic tools inform clinical care policy.
<h3>Importance</h3> Understanding of SARS-CoV-2 infection in US children has been limited by the lack large, multicenter studies with granular data. <h3>Objective</h3> To examine characteristics, changes over time, outcomes, and severity risk factors within National COVID Cohort Collaborative (N3C). <h3>Design, Setting, Participants</h3> A prospective cohort study encounters end dates before September 24, 2021, was conducted at 56 N3C facilities throughout US. Participants included younger...
The majority of U.S. reports COVID-19 clinical characteristics, disease course, and treatments are from single health systems or focused on one domain. Here we report the creation National COVID Cohort Collaborative (N3C), a centralized, harmonized, high-granularity electronic record repository that is largest, most representative cohort cases controls to date. This multi-center dataset supports robust evidence-based development predictive diagnostic tools informs critical care policy.In...
OBJECTIVE The purpose of the study is to evaluate relationship between HbA1c and severity coronavirus disease 2019 (COVID-19) outcomes in patients with type 2 diabetes (T2D) acute COVID-19 infection. RESEARCH DESIGN AND METHODS We conducted a retrospective using observational data from National COVID Cohort Collaborative (N3C), longitudinal, multicenter U.S. cohort Patients were ≥18 years old T2D confirmed infection by laboratory testing or diagnosis code. primary outcome was 30-day...
Abstract Objective The goals of this study were to harmonize data from electronic health records (EHRs) into common units, and impute units that missing. Materials Methods National COVID Cohort Collaborative (N3C) table laboratory measurement data—over 3.1 billion patient over 19 000 unique concepts in the Observational Medical Outcomes Partnership (OMOP) common-data-model format 55 partners. We grouped ontologically similar OMOP together for 52 variables relevant COVID-19 research,...
Abstract Importance SARS-CoV-2 Objective To determine the characteristics, changes over time, outcomes, and severity risk factors of affected children within National COVID Cohort Collaborative (N3C) Design Prospective cohort study patient encounters with end dates before May 27th, 2021. Setting 45 N3C institutions Participants Children <19-years-old at initial testing Main Outcomes Measures Case incidence demographic comorbidity factors, vital sign laboratory trajectories, clinical acute...
Abstract Heartland virus was first isolated in 2009 from two patients Missouri and is transmitted by the Lone Star tick, Amblyomma americanum. To understand disease transmission pathogenesis, it necessary to develop an animal model which utilizes natural route of manifests a manner similar documented human cases. Herein we describe our investigations on identifying A129 mice as most appropriate small for HRTV pathogenesis that mimics clinical outcomes. We further investigated impact tick...
OBJECTIVE To evaluate the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity with longer-term glycemic control weight in people type diabetes (T2D) U.S. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study using longitudinal electronic health record data patients SARS-CoV-2 from National COVID Cohort Collaborative (N3C). Patients were ≥18 years old an ICD-10 diagnosis T2D at least one HbA1c measurement prior to after index date...
Renal biopsy is the gold standard for diagnosis of both native and allograft renal diseases. We studied impact tissue procurement at bedside (TPB) omission on adequacy biopsies.We compared 120 biopsies collected during 2015 using TPB with 111 2016 when was discontinued. Adequacy criteria were applied as follows: by light microscopy, 10 glomeruli two arteries seven biopsies. At least one glomerulus considered adequate immunofluorescence electron microscopy in groups.The rate inadequacies...
Squamous cell carcinoma of the vulva (vSCC) is currently categorized either as human papillomavirus (HPV) associated or independent. Immunohistochemical stains, p16 INK4a (p16) and p53 are helpful biomarkers to support designation vSCC into 1 3 tumor pathways: (1) HPV-associated, (2) HPV-independent, TP53 mutant, (3) wild type. Recently, a framework expression patterns in was proposed. In this international multi-institutional study, we evaluated interrater agreement for pathway...
Dural marginal zone lymphoma (DMZL) is a very rare type of central nervous system that does not involve brain parenchyma. The differential diagnosis includes meningiomas and metastasis, which can make the difficult. DMZL has been considered indolent in literature. Here we report additional two new cases DMZL; one had transformation to diffuse large B-cell (DLBCL), while other complex cytogenetics, indicating potential for DLBCL transformation, genetics associated with unfavorable prognosis...