A5007133528- Research Data Management Practices
- Scientific Computing and Data Management
- Big Data and Business Intelligence
- Distributed and Parallel Computing Systems
- Data Quality and Management
- Pregnancy and preeclampsia studies
- Electronic Health Records Systems
- Ethics in Clinical Research
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Open Source Software Innovations
- Peer-to-Peer Network Technologies
- Ultrasound in Clinical Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Ultrasound Imaging and Elastography
- Parallel Computing and Optimization Techniques
- COVID-19 and healthcare impacts
- Health and Medical Research Impacts
- Birth, Development, and Health
- Medical Imaging Techniques and Applications
- Numerical Methods and Algorithms
- Innovation Policy and R&D
- Drug Transport and Resistance Mechanisms
- Neonatal Health and Biochemistry
University of Iowa
2005-2025
Collaborative Research Group
2021
Cohort (United Kingdom)
2021
Regenstrief Institute
2019
Indiana Clinical and Translational Sciences Institute
2019
University School
2019
Iowa City VA Medical Center
1985
The National COVID Cohort Collaborative (N3C) is a centralized, harmonized, high-granularity electronic health record repository that the largest, most representative COVID-19 cohort to date. This multicenter data set can support robust evidence-based development of predictive and diagnostic tools inform clinical care policy.
Managing clinical trials is a complex process requiring careful integration of human, technology, compliance, and operations for success. We collaborated with experts to develop multi-axial Clinical Trials Management Ecosystem (CTME) maturity model (MM) help institutions identify best practices CTME capabilities. A working group research informaticists was established. An online session on models hosted, followed by review the candidate domain axes finalization axes. Next, level attributes...
Salmonella enterica serovar Typhimurium causes human gastroenteritis and a systemic typhoid-like infection in mice. Infection is initiated by entry of the bacteria into intestinal epithelial cells mediated type III secretion system that encoded genes pathogenicity island 1. The expression invasion tightly regulated environmental conditions such as oxygen osmolarity, well many bacterial factors. hilA gene encodes an OmpR/ToxR family transcriptional regulator activates response to both genetic...
Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, adoption electronic data warehouses for research (EDW4R) containing from health record systems is nearly ubiquitous. Although benefits EDW4R include more effective, efficient support scientists, little known about how CTSA hubs have implemented services. The goal this qualitative study was to understand the ways in which operationalized clinical translational researchers.After conducting semistructured...
Among National Institutes of Health Clinical and Translational Science Award (CTSA) hubs, effective approaches for enterprise data warehouses research (EDW4R) development, maintenance, sustainability remain unclear. The goal this qualitative study was to understand CTSA EDW4R operations within the broader contexts academic medical centers technology.
The morphology of the microcirculation uveal melanomas is a reliable market tumor progression. Scanning electron microscopy cast corrosion preparations can generate three-dimensional views these vascular patterns, but this technique sacrifices parenchyma. Formalin-fixed wet tissue sections 100-150 microns thick from were stained with lectin Ulex europaeus agglutinin I (UEAI) and proliferating cell nuclear antigen (PCNA) to demonstrate simultaneously blood vessels cells. Indocarbocyanine...
In this study we tested the efficacy of quantitative texture analysis in identification acute myocardial ischemia using an ultrasound data acquisition system that digitizes and stores echocardiographic polar format. nine closed-chest dogs, were acquired before after coronary occlusion a 2.4 MHz system. Regions interest analyzed at end-diastole end-systole from ischemic area normal same depth field. Ultrasound evaluated previously reported gray level measures. After occlusion, changes...
Enterprise data warehouses for research (EDW4R) is a critical component of National Institutes Health Clinical and Translational Science Award (CTSA) hubs. EDW4R operations have unique needs that require specialized skills collaborations across multiple domains which limit the ability to apply existing models information technology (IT) performance. Because this uniqueness, we developed new maturity model based on prior qualitative study operational practices supporting EDW4Rs at CTSA In...
This manuscript will be of interest to most Clinical and Translational Science Awards (CTSA) as they retool for the increasing emphasis on translational science from research. effort is an extension EDW4R work that CTSAs have done deploy infrastructure tools researchers access clinical data.
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in formation ofd-glucuronides. binding site aglycone located N-terminal half protein. Using NMR analysis, we demonstrate opioid within 84 to 118 amino acids. Three maltose protein-UGT2B7 fusion proteins, 2B7F3 2B7F4 incorporating acids 24 96 UGT2B7, respectively, 2B7F5 were expressed <i>Escherichia coli</i>and...
OBJECTIVES/GOALS: The CTSA consortium’s Informatics Enterprise Committee has developed a maturity assessment model for Clinical Trial Management Ecosystems (CTME). This poster will show the improvements achieved using this at University of Iowa as well guidance on how to apply it other hubs. METHODS/STUDY POPULATION: CTME consists 11 categories including, study management; regulatory; financial; and reporting. Each category 3 subcategories: standardization; complexity; monitoring, while each...
Healthcare organizations, including Clinical and Translational Science Awards (CTSA) hubs funded by the National Institutes of Health, seek to enable secondary use electronic health record (EHR) data through an enterprise warehouse for research (EDW4R), but optimal approaches are unknown. In this qualitative study, our goal was understand EDW4R impact, sustainability, demand management, accessibility.
Abstract A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. There are no templates what such an encompasses or how it funded. An workgroup within the Clinical and Translational Science Awards network conducted analysis to identify scope, governance, funding of this infrastructure. After we identified components infrastructure, surveyed leaders at institutions about governance sustainability different components. Results...
In this study we tested the efficacy of quantitative texture analysis in identification acute myocardial ischemia using an ultrasound data acquisition system that digitizes and stores echocardiographic polar format. nine closed-chest dogs, were acquired before after coronary occlusion a 2.4 MHz system. Regions interest analyzed at end-diastole end-systole from ischemic area normal same depth field. Ultrasound evaluated previously reported gray level measures. After occlusion, changes...
Resource discovery technologies for Grids and Peer-to-Peer (P2P) systems share some characteristics. However, P2P such as Skip Graph cannot simply be applied to Grid resource because complex grid resources need searched by using multi-attribute queries. This paper proposes a new approach (SkipMard) that extends structure support SkipMard provides prefix matching routing algorithm resolve queries, introduces the concepts of "layer" "crossing layer nearest neighbor" into data structure. To...
Abstract This paper proposes the creation and application of maturity models to guide institutional strategic investment in research informatics information technology (research IT) provide ability measure readiness for clinical infrastructure as well sustainability expertise. Conducting effective efficient health science increasingly relies upon robust IT systems capabilities. Academic centers are increasing investments address operational pressures, including rapidly growing data,...
To improve maternal health outcomes, increased diversity is needed among pregnant people in research studies and community surveillance. expand the pool, we sought to develop a network encompassing academic obstetrics clinics. Typical challenges developing include site identification, contracting, onboarding sites, staff engagement, participant recruitment, funding, institutional review board approvals. While not insurmountable, these became magnified as built during global pandemic. Our...
SPARCRequest© (Services, Pricing, & Application for Research Centers) is a web-based research management system that provides modular and adaptable "electronic storefront" research-related services. Developed by the South Carolina Clinical Translational Institute at Medical University of Carolina, it was released as open source (OS) code in 2014. The adoption accelerated 2016, when, to ensure responsiveness needs partners, its governance also became open. This model enables OS partners...