A5085379143- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Biomedical Text Mining and Ontologies
- AI in cancer detection
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Scientific Computing and Data Management
- Electronic Health Records Systems
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Genetics, Bioinformatics, and Biomedical Research
- Research Data Management Practices
- Pleural and Pulmonary Diseases
- Biomedical and Engineering Education
- Radiology practices and education
- Gene expression and cancer classification
- Clinical Laboratory Practices and Quality Control
- Long-Term Effects of COVID-19
- Prostate Cancer Diagnosis and Treatment
- Ethics in Clinical Research
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Health, Environment, Cognitive Aging
University of Pittsburgh
2015-2025
UPMC Hillman Cancer Center
2001-2024
Bioscience (China)
2022
Biomedical Informatics Research Center Antwerp
2007-2020
University of Pittsburgh Medical Center
1994-2010
The University of Texas Health Science Center at Houston
2009
National Institutes of Health
2008
University of Pennsylvania
2008
Medical College of Wisconsin
2005
University of Illinois Chicago
2005
The incidence of prostate cancer is frequent, occurring in almost one-third men older than 45 years. Only a fraction the cases reach stages displaying clinical significance. Despite advances our understanding carcinogenesis and disease progression, knowledge this still fragmented. Identification genes patterns gene expression will provide more cohesive picture biology.In study, we performed comprehensive analysis on 152 human samples including tissues, tissues adjacent to tumor, organ donor...
Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of tumor. Metastasis reflects most adverse outcome prostate cancer, and to date there are no reliable or serum biomarkers can reliably predict which patients at higher risk developing metastatic disease. Understanding differences biology organ confined primary tumors essential for new prognostic markers therapeutic targets.Using Affymetrix oligonucleotide arrays,...
Abstract Prostate cancer is a biologically heterogeneous disease with considerable variation in clinical aggressiveness. The behavior of prostate can be considered direct or indirect result aberrant alterations gene expression epithelial cells. Identification the patterns gene‐expression that are related to aggressiveness cancers will greatly assist development tools for early detection poor outcome and identification targets future therapeutic intervention. To detect cancers, we performed...
The Human Genome Project (HGP) provided the initial draft of mankind's DNA sequence in 2001. HGP was produced by 23 collaborating laboratories using Sanger sequencing mapped regions as well shotgun techniques a process that occupied 13 years at cost ~$3 billion. Today, Next Generation Sequencing (NGS) represent next phase evolution technology dramatically reduced compared to traditional sequencing. A single laboratory today can entire human genome few days for thousand dollars reagents and...
Sharing biomedical research and health care data is important but difficult.Recognizing this, many initiatives facilitate, fund, request, or require researchers to share their [1][2][3][4][5] .These address the technical aspects of sharing, rarely focus on incentives for key stakeholders [6].Academic centers (AHCs) have a critical role in enabling, encouraging, rewarding sharing.The leaders medical schools academic-affiliated hospitals can play unique supporting this transformation...
We define the scope and needs within new discipline of computational pathology, a critical to future both practice pathology and, more broadly, medical in general.To pathology.A meeting was convened Boston, Massachusetts, July 2014 prior annual Association Pathology Chairs meeting, it attended by variety pathologists, including individuals highly invested informatics as well chairs departments.The made recommendations promote clearly defining field articulating its value propositions;...
Abstract The Accrual to Clinical Trials (ACT) network is a federated of sites from the National and Translational Science Award (CTSA) Consortium that has been created significantly increase participant accrual multi-site clinical trials. ACT represents an unprecedented collaboration among diverse CTSA sites. governance regulatory frameworks common data model harmonize electronic health record (EHR) data, deployed set Informatics for Integrating Biology Bedside (i2b2) repositories are linked...
Growing numbers of artificial intelligence applications are being developed and applied to pathology laboratory medicine. These technologies introduce risks benefits that must be assessed managed through the lens ethics. This article describes how long-standing principles medical scientific ethics can using examples from
Typical high throughput microarrays experiments compare gene expression across two specimen classes - an experimental class and baseline (or comparison) class. The choice of is a major factor in the differential patterns revealed by these experiments. In most studies prostate cancer, histologically malignant tissue chosen as while normal appearing adjacent to tumor (adjacent normal) against which comparison made. However, from free organ donors represents alterative source for studies.
The incidence of prostate cancer has surged dramatically in recent years due to improved screening and detection mechanisms. There also been significant interest specifically pertaining the increased younger males, which might be screening. We analyzed our data set incidental cancer, derived from a project accruing tissues for research normal organ donors, who are predominantly white population.Information about any prior this cohort was not available. In addition, population had no history...
The COVID-19 pandemic has been associated with increased neuropsychiatric conditions in children and youths, evidence suggesting that SARS-CoV-2 infection may contribute additional risks beyond stressors. This study aimed to assess the full spectrum of positive (ages 5-12) youths 12-20) compared a matched negative cohort, accounting for factors influencing risk. Using EHR data from 25 institutions RECOVER program, we conducted retrospective analysis 326,074 887,314 participants risk...
Abstract IMPORTANCE Prior studies have demonstrated the effectiveness of COVID-19 vaccines in children and adolescents. However, benefits vaccination these age groups with prior infection remain underexplored. OBJECTIVE To evaluate preventing reinfection various Omicron subvariants (BA.1/2, BA.4/5, XBB, later) among 5- to 17-year-olds SARS-CoV-2 infection. DESIGN A target trial emulation through nested designs distinct study periods. SETTING The utilized data from Research COVID Enhance...
Abstract BACKGROUND. Honest broker services are essential for tissue‐ and data‐based research. The honest provides a firewall between clinical research activities. Clinical information is stripped of Health Insurance Portability Accountability Act‐denoted personal health identifiers. Research material may have linkage codes, precluding the identification patients to researchers. data derived from sources. These use only, there rules in place that prohibit reidentification. Very rarely,...
Pathology informatics has evolved to varying levels around the world. The history of pathology in different countries is a tale with many dimensions. At first glance, it familiar story individuals solving problems that arise their clinical practice enhance efficiency, better manage (e.g., digitize) laboratory information, as well exploit emerging information technologies. Under surface, however, lie powerful resource, regulatory, and societal forces helped shape our discipline into what...
The PaTH (University of Pittsburgh/UPMC, Penn State College Medicine, Temple University Hospital, and Johns Hopkins University) clinical data research network initiative is a collaborative effort among four academic health centers in the Mid-Atlantic region. will provide robust infrastructure to conduct research, explore outcomes, link with biospecimens, improve methods for sharing analyzing across our diverse populations. Our disease foci are idiopathic pulmonary fibrosis, atrial...
Abstract Purpose To characterize and analytically validate the MSDA Test, a multi‐protein, serum‐based biomarker assay developed using Olink ® PEA methodology. Experimental design Two lots of Test panel were manufactured subjected to comprehensive analytical characterization validation protocol detect biomarkers present in serum patients with multiple sclerosis (MS). Biomarker concentrations incorporated into final algorithm used for calculating four Disease Pathway scores (Immunomodulation,...
Managing clinical trials is a complex process requiring careful integration of human, technology, compliance, and operations for success. We collaborated with experts to develop multi-axial Clinical Trials Management Ecosystem (CTME) maturity model (MM) help institutions identify best practices CTME capabilities. A working group research informaticists was established. An online session on models hosted, followed by review the candidate domain axes finalization axes. Next, level attributes...
Importance The profile of gastrointestinal (GI) tract outcomes associated with the postacute and chronic phases COVID-19 in children adolescents remains unclear. Objective To investigate risks GI symptoms disorders during (28-179 days after documented SARS-CoV-2 infection) (180-729 pediatric population. Design, Setting, Participants This retrospective cohort study was performed from March 1, 2020, to September 2023, at 29 US health care institutions. included patients 18 years or younger...