A5003955673- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Ethics in Clinical Research
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Cardiovascular Health and Disease Prevention
- Electrolyte and hormonal disorders
- Pelvic floor disorders treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Treatment and Pharmacology
- Cardiovascular Health and Risk Factors
- Anorectal Disease Treatments and Outcomes
- Biomedical Ethics and Regulation
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Influenza Virus Research Studies
- Blood Pressure and Hypertension Studies
- Ethics in medical practice
- BRCA gene mutations in cancer
- Neonatal Respiratory Health Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pregnancy-related medical research
- Adipokines, Inflammation, and Metabolic Diseases
University of Iowa Hospitals and Clinics
2017-2024
New York University
2024
University of Iowa
2011-2023
University Physicians
2022
March of Dimes
2022
Cincinnati Children's Hospital Medical Center
2022
Yale Cancer Center
2014-2021
University at Buffalo, State University of New York
2021
Carver Bible College
2021
Smilow Cancer Hospital
2017-2018
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Antiemesis address all aspects of management chemotherapy-induced nausea and vomiting. These Insights focus on recent updates to the Antiemesis, specifically those regarding carboplatin, granisetron, olanzapine.
In Brief OBJECTIVE: We sought to estimate the prevalence of pelvic organ prolapse in older women using Pelvic Organ Prolapse Quantification examination and identify factors associated with prolapse. METHODS: Women a uterus enrolled at one site Women's Health Initiative Hormone Replacement Therapy randomized clinical trial were eligible for this ancillary cross-sectional study. Subjects underwent during maximal Valsalva maneuver addition completed questionnaire. Logistic regression was used...
In Brief OBJECTIVE: Because of a widespread but untested belief that increased intra-abdominal pressure contributes to pelvic floor disorders, physicians commonly restrict various activities postoperatively. Our aim was describe pressures during common physical activities. METHODS: Thirty women wide age and weight ranges who were not undergoing treatment for disorders performed 3 repetitions while (baseline maximal) approximated via microtip rectal catheters. We calculated median peak net...
It is unclear how genomic incidental finding (GIF) prospects should be addressed in informed consent processes. An exploratory study on this topic was conducted with 34 purposively sampled Chairs of institutional review boards (IRBs) at centers conducting genome-wide association studies. Most (96%) reported no knowledge local IRB requirements regarding GIFs and consent. suggested processes address the prospect of, disclosure policy on, GIFs; GIF management follow-up; potential clinical...
Next generation sequencing offers benefit of improved health through knowledge, but comes with challenges, such as inevitable incidental findings (IFs). The applicability recommended criteria for disclosure individual results when applied to IFs is not well known. purpose this study was examine how medical genetic specialists, genomic researchers, and Institutional Review Board (IRB) chairs perceive the importance genetic/genomic IFs. We conducted telephone interviews specialists (genetic...
Patients with plasma cell dyscrasias (PCDs) experience an increased burden of influenza, and current practice single-dose annual influenza vaccination yields suboptimal protective immunity in these patients. Strategies to improve patients are clearly needed. We performed a randomized, double-blind, placebo-controlled clinical trial comparing tandem Fluzone High-Dose standard-of-care vaccination. Standard-of-care was age-based (standard dose, <65 years; high ≥65 years), this arm received...
Genomic research can produce findings unrelated to a study's aims. The purpose of this study was examine researcher and Institutional Review Board (IRB) chair perspectives on genomic incidental (GIFs).Nineteen researchers 34 IRB chairs from 42 institutions participated in semi-structured telephone interviews. Researchers described GIFs within their respective roles. Few had direct experience with disclosure GIFs. favored policies where case by determination regarding whether GIF would be...
Women with preeclampsia, a hypertensive disorder of pregnancy, exhibit greater beat-to-beat blood pressure variability (BPV) in the third trimester after clinical onset disorder. However, it remains unknown whether elevated BPV precedes development preeclampsia. A prospective study cohort 139 women (age 30.2±4.0 years) were enrolled early pregnancy (<14 weeks gestation). was quantified by time domain analyses 10-minute continuous recordings via finger photoplethysmography first, second, and...
<h3>Background</h3> Genomic research is challenging the tradition of informed consent. researchers in USA, Canada and parts Europe are encouraged to use consent address prospect disclosing individual results (IRRs) study participants. In no national policy exists direct this consent, it unclear how local institutional review boards (IRBs) may want respond. <h3>Objective methods</h3> To explore publicly accessible IRB websites for guidance area, using summative content analysis....
Abstract Background Women with a history of preeclampsia (hxPE) exhibit sustained arterial stiffness and elevated blood pressure postpartum. Aortic 24-hour variability (BPV) are associated age-related cognitive decline. Although hxPE is related to altered function, the association between aortic BPV performance in young women has not been investigated. The objectives this study were (i) test whether lower (ii) determine independent average pressure. Methods (N = 23) healthy pregnancy...
Abstract Introduction: Adverse childhood experiences (ACEs) are a measure of adversity and associated with life-long morbidity. The impacts ACEs on peripartum health including preeclampsia, common dangerous hypertensive disorder pregnancy, remain unclear, however. Therefore, we aimed to determine ACE association psychiatric prevalence preeclampsia using case–control design. Methods: Clinical data were aggregated validated large, intergenerational knowledgebase developed at our institution....
Depression and preeclampsia share risk factors are bi-directionally associated with increased for each other. Despite epidemiological evidence linking selective serotonin reuptake inhibitors (SSRIs) in pregnancy to preeclampsia, (5-HT) vasopressin (AVP) secretion mechanisms suggest that SSRIs may attenuate risk. However, there is a need clarify the relationship between humans determine therapeutic potential. This retrospective cohort study included clinical data from 9558 SSRI-untreated 9046...
Purpose: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was determine whether the acquisition integration oncology by Yale/Smilow Cancer Hospital improved outcomes in quality care, disease team integration, trial accrual, patient satisfaction at network practice sites. Methods: We evaluated testing hypothesis that core Quality Oncology Practice Initiative measures sites were 2012 significantly...
Worksite-based wellness programs can be a means to improve employee health awareness and potentially reduce care costs. The "BP Success Zone: You Auto Know" program was worksite-based intervention the incidence of hypertension among auto workers at Chrysler LLC. This 6-month comprised an consisting education, awareness, support intended intensify engagement employees moderate-to-high cardiovascular risk who were not adequately controlling their blood pressure. 539 participants had systolic...
Treatment decisions should be based on patients’ goals of care to provide an ethical, patient-centered framework for decision making. The purpose this study is improve our understanding about how and surrogates’ are communicated interpreted in medical intensive unit (MICU). One hundred patients admitted MICU, or their surrogates, responded open-ended question hospitalization followed by a closed-ended regarding most important goal care. Investigators participants’ responses compared these...
Diabetes during pregnancy is associated with elevated maternal insulin, leptin and IL-6. Within the placenta, IL-6 can further stimulate production. Despite structural similarities shared roles in inflammation, have contrasting effects on neurodevelopment, relative importance of diabetes or chorioamnionitis fetal hormone exposure has not been defined. We hypothesized that there would be a positive correlation between progressively increased levels pregnancies complicated by chorioamnionitis....
Abstract Upon receipt of the National Institutes Health Clinical and Translational Science Award, University Iowa’s Institute for committed to develop an infrastructure research professionals. Three goals were established: (1) identification professionals within Iowa, (2) development educational series, including orientation continuing education, (3) a mentoring system. The purpose this paper is describe process development, initiation, outcomes successful networking, educational, system...
To improve maternal health outcomes, increased diversity is needed among pregnant people in research studies and community surveillance. expand the pool, we sought to develop a network encompassing academic obstetrics clinics. Typical challenges developing include site identification, contracting, onboarding sites, staff engagement, participant recruitment, funding, institutional review board approvals. While not insurmountable, these became magnified as built during global pandemic. Our...
Abstract This article provides pragmatic advice for organizations interested in creating a research ethics consultation service (RECS). A robust RECS has the potential to build capacity among investigators identify and consider ethical issues they encounter while conducting their research. Determining whether establish an should begin with institutional‐needs assessment that includes three key questions: What are current resources available teams navigate concerns arise from research? Is...