A5037342300- Inertial Sensor and Navigation
- Energy Efficient Wireless Sensor Networks
- Mobile Agent-Based Network Management
- Biomedical Text Mining and Ontologies
- Kawasaki Disease and Coronary Complications
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Semantic Web and Ontologies
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Coronary Artery Anomalies
- Renal function and acid-base balance
- Cardiac Structural Anomalies and Repair
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Neonatal and Maternal Infections
- Thermal Regulation in Medicine
- Otolaryngology and Infectious Diseases
- Machine Learning in Healthcare
- Healthcare Technology and Patient Monitoring
- Streptococcal Infections and Treatments
University of Colorado Denver
2016-2025
Children's Hospital Colorado
2016-2024
University of Colorado Anschutz Medical Campus
2020-2022
Office of Infectious Diseases
2015
Hospital Infantil Universitario Niño Jesús
2009
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions and Septic Shock (Sepsis-3) defined as life-threatening organ dysfunction caused by dysregulated host response to infection, but it excluded children. Objective To update evaluate septic shock Evidence Review The Society Critical Care Medicine (SCCM) convened task force 35...
<h3>Importance</h3> Understanding of SARS-CoV-2 infection in US children has been limited by the lack large, multicenter studies with granular data. <h3>Objective</h3> To examine characteristics, changes over time, outcomes, and severity risk factors within National COVID Cohort Collaborative (N3C). <h3>Design, Setting, Participants</h3> A prospective cohort study encounters end dates before September 24, 2021, was conducted at 56 N3C facilities throughout US. Participants included younger...
Importance The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis septic shock using measures organ dysfunction through a data-driven approach. Objective To derive novel across differently resourced settings. Design, Setting, Participants Multicenter, international, retrospective cohort study in 10 health systems the US, Colombia, Bangladesh, China, Kenya, 3 which were used as external validation...
This cohort study uses data from the US National COVID Cohort Collaborative to evaluate upper airway infections in children during surge of Omicron (B.1.1.529) variant SARS-CoV-2 US.
Electronic Health Record (EHR) systems typically define laboratory test results using the Laboratory Observation Identifier Names and Codes (LOINC) can transmit them Fast Healthcare Interoperability Resource (FHIR) standards. LOINC has not yet been semantically integrated with computational resources for phenotype analysis. Here, we provide a method mapping LOINC-encoded transmitted in FHIR standards to Human Phenotype Ontology (HPO) terms. We annotated medical implications of 2923 commonly...
BackgroundKawasaki disease (KD) remains a clinical diagnosis due to the absence of sensitive and specific diagnostic test. There are limited published data on usefulness procalcitonin (PCT) as biomarker for or prognosis children with KD. We hypothesized that PCT might be useful in predicting coronary artery lesions (CALs) intravenous immunoglobulin (IVIG) resistance.
Abstract Common data models solve many challenges of standardizing electronic health record (EHR) but are unable to semantically integrate all the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Foundry ontologies provide computable representations biological knowledge enable integration heterogeneous data. However, mapping EHR OBO requires significant manual curation domain expertise. We introduce OMOP2OBO, an algorithm Observational Medical Outcomes...
Abstract Importance SARS-CoV-2 Objective To determine the characteristics, changes over time, outcomes, and severity risk factors of affected children within National COVID Cohort Collaborative (N3C) Design Prospective cohort study patient encounters with end dates before May 27th, 2021. Setting 45 N3C institutions Participants Children <19-years-old at initial testing Main Outcomes Measures Case incidence demographic comorbidity factors, vital sign laboratory trajectories, clinical acute...
This diagnostic study assesses the ability of a pediatric blood pressure percentile tool to accelerate identification children with hypertension and hypotension by clinicians researchers.
Kawasaki Disease (KD), a systemic vasculitis of medium sized vessels, is the most common cause acquired heart disease among children in developed world. Some KD patients demonstrate echocardiographic evidence depressed myocardial mechanics. However, incidence, etiology, and reversibility abnormal mechanics remain undefined.We retrospectively studied 41 measured strain rate by velocity vector imaging from pre-treatment convalescent echocardiograms. Pre-treatment procalcitonin, C-reactive...
BACKGROUND AND OBJECTIVES Serious bacterial infection (SBI) is common in the PICU. Antibiotics can mitigate associated morbidity and mortality but have adverse effects. Our objective to develop machine learning models able identify SBI-negative children reduce unnecessary antibiotics. METHODS We developed predict status at PICU admission using vital sign, laboratory, demographic variables. Children 3-months 18-years-old admitted our PICU, between 2011 2020, were included if evaluated for...
The overwhelming majority of pediatric cases SARS-CoV-2 infection are mild or asymptomatic with only a handful deaths reported. We present case severe COVID-19 in patient signs hyperinflammation and consumptive coagulopathy requiring intubation extracorporeal membrane oxygenation (ECMO) eventual death due to ECMO complications.
Abstract Background Identifying children ready for transfer out of the pediatric intensive care unit (PICU) is an area that may benefit from clinical decision support (CDS). We previously implemented a quality improvement (QI) initiative to accelerate evaluation non–medically complex PICU patients with viral bronchiolitis receiving floor-appropriate respiratory support. Objectives Design CDS tool adaptation this QI further appropriate patients. Methods The original focused on identifying...
Specific criteria for de-escalation from the PICU are often not included in viral bronchiolitis institutional pathways. Variability of transfer preferences can prolong length stay. We aimed to decrease time reaching floor-appropriate heated high flow nasal cannula (HHF) settings decision by 20% through standardizing PICU-to-floor assessment a cohort.We admissions October 2019 April 2020, who were 6-months 2-years-old with no comorbidities nor intubation during their encounter. Our...
Background: When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial (IBIs). We sought to evaluate change in epidemiology and relationships between specific VRIs IBIs [complicated pneumonia, complicated sinusitis group A streptococcus (iGAS)] over time using National COVID Cohort Collaborative (N3C) dataset. Methods: performed a secondary analysis all prospectively collected...
Mechanistic interpretability has been explored in detail for large language models (LLMs). For the first time, we provide a preliminary investigation with similar methods medical imaging. Specifically, analyze features from ViT-Small encoder obtained pathology Foundation Model via application to two datasets: one dataset of images, and images paired spatial transcriptomics. We discover an interpretable representation cell tissue morphology, along gene expression within model embedding space....
Abstract Background Reports of SARS-CoV-2 causing laryngotracheobronchitis (commonly known as croup) have been limited to small case series. Early reports suggest the Omicron (B.1.1.529) strain (the dominant circulating US since week 12/25/2021) replicates more efficiently in conducting airways. This may increase risk a croup phenotype children they smaller airway calibers. Methods Description incidence, change over time, and characteristics with upper infection (UAI) diagnoses within...