A5080466311- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Biomedical Text Mining and Ontologies
- Climate Change and Health Impacts
- Cellular transport and secretion
- Cardiac electrophysiology and arrhythmias
- Ethics in Clinical Research
- Bioinformatics and Genomic Networks
- Electronic Health Records Systems
- Sensor Technology and Measurement Systems
- Evolutionary Psychology and Human Behavior
- Healthcare Quality and Management
- Neuroscience and Neural Engineering
- Face recognition and analysis
- Insect Resistance and Genetics
- Adipokines, Inflammation, and Metabolic Diseases
- Cultural Heritage Management and Preservation
- Lipid metabolism and disorders
- Canadian Identity and History
- Cell Image Analysis Techniques
- Face Recognition and Perception
- Machine Learning in Healthcare
Australian National University
2023-2024
University of North Carolina at Chapel Hill
2019-2021
University of North Carolina Health Care
2021
Morehouse School of Medicine
2020
University of Tennessee at Knoxville
1974
Background In a multisite clinical research collaboration, institutions may or not use the same common data model (CDM) to store data. To overcome this challenge, we proposed Health Level 7’s Fast Healthcare Interoperability Resources (FHIR) as meta-CDM—a single standard represent Objective study, aimed create an open-source application termed Clinical Asset Mapping Program for FHIR (CAMP FHIR) efficiently transform supporting source-agnostic CDM-to-FHIR mapping. Methods with CAMP involves...
Electronic Health Record (EHR) systems typically define laboratory test results using the Laboratory Observation Identifier Names and Codes (LOINC) can transmit them Fast Healthcare Interoperability Resource (FHIR) standards. LOINC has not yet been semantically integrated with computational resources for phenotype analysis. Here, we provide a method mapping LOINC-encoded transmitted in FHIR standards to Human Phenotype Ontology (HPO) terms. We annotated medical implications of 2923 commonly...
Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found be the strongest factor associated with obesity. Here we show that elevation of human CRP at baseline level causes The obesity phenotype confirmed whole-body magnetic resonance imaging (MRI), in which total fat mass 6-9 folds higher rats than control rats. Univariate linear regression analysis showed different growth rates between rats,...
This study aimed to develop a novel, regulatory-compliant approach for openly exposing integrated clinical and environmental exposures data: the Integrated Clinical Environmental Exposures Service (ICEES).The driving use case research development of ICEES was asthma, which is common disease influenced by hundreds genes plethora exposures, including airborne pollutants. We developed pipeline integrating data on patients with asthma-like conditions derived from multiple public sources. The...
Abstract Background Informatics tools to support the integration and subsequent interrogation of spatiotemporal data such as clinical environmental exposures are lacking. Such needed research in health any biomedical field that is challenged by need for integrated examine individual-level determinants disease. Results We have developed an open-source software application—FHIR PIT (Health Level 7 Fast Healthcare Interoperability Resources Patient Integration Tool)—to enable studies on impact...
Voltage gated sodium channels (Na v ) are membrane proteins which open to facilitate the inward flux of ions into excitable cells. In response stimuli, Na transition from resting, closed state an open, conductive state, before rapidly inactivating. Dysregulation this functional cycle due mutations causes diseases including epilepsy, pain conditions and cardiac disorders, making a significant pharmacological target. Phosphoinositides important lipid cofactors for ion channel function. The...
Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of ions into excitable cells. In response stimuli, Naᵥ transition from resting, closed state an open, conductive state, before rapidly inactivating. Dysregulation this functional cycle due mutations causes diseases including epilepsy, pain conditions, and cardiac disorders, making a significant pharmacological target. Phosphoinositides important lipid cofactors for ion channel function. The...
Abstract Background Informatics tools to support the integration and subsequent interrogation of spatiotemporal data such as clinical environmental exposures are lacking. Such needed research in health any biomedical field that is challenged by need for integrated examine individual-level determinants disease. Results We have developed an open-source software application—FHIR PIT (Health Level 7 Fast Healthcare Interoperability Resource Patient Integration Tool)—to enable studies on impact...
Abstract Voltage gated sodium channels (Na v ) are membrane proteins which open to facilitate the inward flux of ions into excitable cells. In response stimuli, Na transition from resting, closed state an open, conductive state, before rapidly inactivating. Dysregulation this functional cycle due mutations causes diseases including epilepsy, pain conditions and cardiac disorders, making a significant pharmacological target. Phosphoinositides important lipid cofactors for ion channel...
Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of ions into excitable cells. In response stimuli, Naᵥ transition from resting, closed state an open, conductive state, before rapidly inactivating. Dysregulation this functional cycle due mutations causes diseases including epilepsy, pain conditions, and cardiac disorders, making a significant pharmacological target. Phosphoinositides important lipid cofactors for ion channel function. The...
As the COVID-19 pandemic continues to impact world, data is being gathered and analyzed better understand disease. Recognizing potential for visual analytics technologies support exploratory analysis hypothesis generation from longitudinal clinical data, a team of collaborators worked apply existing event sequence cohort 998 patients with high rates infection. This paper describes initial steps toward this goal, including: (1) transformation processing work required prepare analysis, (2)...
Abstract Background Informatics tools to support the integration and subsequent interrogation of spatiotemporal data such as clinical environmental exposures are lacking. Such needed research in health any biomedical field that is challenged by need for integrated examine individual-level determinants disease. Results We have developed an open-source software application—FHIR PIT (Health Level 7 Fast Healthcare Interoperability Resources Patient Integration Tool)—to enable studies on impact...
Voltage gated sodium channels (Na v ) are membrane proteins which open to facilitate the inward flux of ions into excitable cells. In response stimuli, Na undergo a transition from resting, closed state an allows ion influx, before rapidly inactivating. Dysregulation this functional cycle due mutations leads diseases including epilepsy, pain conditions and cardiac disorders, making significant pharmacological target. Phosphoinositides important lipid cofactors for channel function. The...
Abstract Electronic Health Record (EHR) systems typically define laboratory test results using the Laboratory Observation Identifier Names and Codes (LOINC) can transmit them Fast Healthcare Interoperability Resource (FHIR) standards. LOINC has not yet been semantically integrated with computational resources for phenotype analysis. Here, we provide a method mapping LOINC-encoded transmitted in FHIR standards to Human Phenotype Ontology (HPO) terms. We annotated medical implications of 2421...