A5000078211- Asthma and respiratory diseases
- Advanced Radiotherapy Techniques
- Respiratory viral infections research
- Radiation Therapy and Dosimetry
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atomic and Subatomic Physics Research
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Radiation Effects and Dosimetry
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Food Allergy and Anaphylaxis Research
- Nuclear Physics and Applications
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Congenital Diaphragmatic Hernia Studies
- Eosinophilic Esophagitis
University of Minnesota
2019-2025
University of Minnesota System
2019-2025
Southern California Clinical and Translational Science Institute
2019-2025
Georgia State University
2016-2025
Evans Analytical Group (United States)
2022-2025
Griffith University
2022-2024
Gold Coast Health
2024
McGill University Health Centre
2012-2024
University of Minnesota Medical Center
2023-2024
Evangel University
2024
Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood.To define relationship between illnesses and early childhood development.A total 259 children were followed prospectively from birth to 6 years age. The etiology timing respiratory during assessed using nasal lavage, culture, multiplex reverse transcriptase-polymerase chain reaction....
Aeroallergen sensitization and virus-induced wheezing are risk factors for asthma development during early childhood, but the temporal developmental sequence between them is incompletely understood.To define relationship aeroallergen wheezing.A total of 285 children at high allergic disease were followed prospectively from birth. The timing etiology viral respiratory illnesses determined, was assessed annually first 6 years life. relationships these events using a longitudinal multistate...
Rationale: Human rhinoviruses (HRVs) consist of approximately 160 types that cause a wide range clinical outcomes, including asymptomatic infections, common colds, and severe lower respiratory illnesses.Objectives: To identify factors influence the severity HRV illnesses.Methods: species were determined in 1,445 nasal lavages prospectively collected from 209 infants participating birth cohort who had at least one infection. Questionnaires used during each illness to moderate illnesses...
Purpose: To prospectively compare apparent diffusion coefficient (ADC) measurements derived from diffusion-weighted hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging with functional and structural findings using spirometric tests thin-section computed tomography (CT) of the lungs in asymptomatic smokers healthy nonsmokers similar age. Materials Methods: All studies were HIPAA compliant approved by institutional review board. Informed consent was obtained. Ventilation 3He MR...
To better understand the viral aetiology of recurrent and prolonged illnesses, nasal secretions were prospectively collected from 285 infants at increased risk developing asthma. Of these, 27 had (at least five) moderate-to-severe respiratory illnesses (MSIs). The 150 MSIs 86 scheduled visits was analysed by molecular diagnostics. demographic clinical data compared with who 0-4 MSIs. Frequently ill higher exposure to other children more wheezing than less symptomatic children. Viruses...
Exacerbations of childhood asthma and rhinovirus infections both peak during the spring fall, suggesting that viral are major contributors to seasonal morbidity.We sought evaluate seasons in children with analyze relationships between infection illness severity.Fifty-eight aged 6 8 years provided 5 consecutive weekly nasal lavage samples September April; symptoms, medication use, flow were recorded. Rhinoviruses identified by using multiplex PCR partial sequencing genomes.Viruses detected...
Aerosol generation with modes of oxygen therapy such as high-flow nasal cannula and noninvasive positive-pressure ventilation is a concern for healthcare workers during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The amount aerosol from tract these various modalities unknown.
Specific patterns of allergic sensitization as well quantification the in vitro IgE response early life may provide relevant clinical insight into future rhinitis and asthma risk.To define relationships among established to particular aeroallergens, quantitative analyses allergen-specific levels, pet exposure sensitization, risk.Children at high-risk for development diseases were enrolled birth Childhood Origins ASThma (COAST) study. Allergen-specific was assessed ages 1, 3, 6, 9 years by...
Mepolizumab, an IL-5-blocking antibody, reduces exacerbations in patients with severe eosinophilic asthma. Mepolizumab arrests eosinophil maturation; however, the functional phenotype of eosinophils that persist blood and airway after administration IL-5 neutralizing antibodies has not been reported.To determine effect anti-IL-5 antibody on numbers phenotypes allergen-induced circulating eosinophils.Airway inflammation was elicited participants mild allergic asthma by segmental allergen...
Rationale: Experimental evidence suggests that CDHR3 (cadherin-related family member 3) is a receptor for rhinovirus (RV)-C, and missense variant in this gene (rs6967330) associated with childhood asthma severe exacerbations.Objectives: To determine whether rs6967330 influences RV-C infections illnesses early childhood.Methods: We studied associations between respiratory the COPSAC2010 (Copenhagen Prospective Studies on Asthma Childhood 2010) COAST (Childhood Origins of Birth Cohort Study)...
Abstract Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods the impact preexisting on probable PASC in adults and children using electronic health record data from multiple research networks. Three networks within REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, National Cohort...