A5021957170- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Herpesvirus Infections and Treatments
- Mechanical Circulatory Support Devices
- Organ Donation and Transplantation
- Psoriasis: Treatment and Pathogenesis
- Cardiac Arrhythmias and Treatments
- Respiratory viral infections research
- Alcoholism and Thiamine Deficiency
- Infant Nutrition and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Biomedical Research and Pathophysiology
- Cardiovascular Effects of Exercise
- Breastfeeding Practices and Influences
- Atrial Fibrillation Management and Outcomes
- Dialysis and Renal Disease Management
- Clinical Nutrition and Gastroenterology
- Food Industry and Aquatic Biology
Baylor College of Medicine
2019-2025
University of Wisconsin–Madison
2018-2020
Oregon Health & Science University
2009-2018
Oregon National Primate Research Center
2005-2018
University of Arizona
2009-2011
Abstract In youth, thymic involution curtails production of new naïve T cells, placing the onus T‐cell maintenance upon secondary lymphoid organs (SLO). This peripheral preserves size pool for much lifespan, but wanes in last third life, leading to a dearth cells blood and SLO, contributing suboptimal immune defense. Both keratinocyte growth factor (KGF) sex steroid ablation (SSA) have been shown transiently increase cellularity old thymus. It is less clear whether this can improve...
Introduction While survival following liver transplantation has improved over the past 3 decades, few studies have examined changes time in hospital length of stay (LOS), a surrogate for healthcare expenditure and an important short-term outcome measure. Research question The purpose this study was to compare post-transplantation LOS last decades. Design A cross-sectional analysis 150 603 adult transplant recipients between September 1987 July 2021 from UNOS database conducted. patients were...
Abstract After infection of epithelial surfaces, HSV-1 elicits a multifaceted antiviral response that controls the virus and limits it to latency in sensory ganglia. That encompasses CD8+ T cells, whose precise role(s) is still being defined; immune surveillance ganglia control viral spread brain were proposed as key roles. We tracked kinetics cell across lymphoid extralymphoid tissues after ocular infection. HSV-1-specific cells first appeared draining (submandibular) lymph node on day 5...
Following the priming and contraction phases of T cell response, latent persistent herpesviruses lead to an accumulation large pools virus-specific CD8 cells, also known as memory inflation (MI). The mechanism this is incompletely understood, largely because molecular reactivation these viruses in vivo its impact upon biology have not been resolved mice, relevant observations humans remain, by necessity, correlative. Understanding processes essential from standpoint proposed critical role...
Abstract Aging is associated with depressed naive T cell responses, but it less clear whether memory established early in life also becomes impaired age. This particularly important for cells responding to latent persistent infection, which need remain functional and capable of controlling the infection over lifetime; however, repeated stimulation lifetime may dysregulate their maintenance or function, potentially contributing immunity elderly. Systemic HSV-1, a virus, inflation...
Abstract The immune system devotes substantial resources to the lifelong control of persistent pathogens, which were hypothesized play an important role in aging. Specifically, presence latent herpesviruses has been correlated with exhaustion and shorter lifespan octogenarians. But neither causality nor mechanistic link(s) established, relative roles antigenic stimulation virus-independent homeostatic disturbances T cell aging remain unresolved. We longitudinally analyzed expansion,...
Fluid overload (FO) in critically ill children correlates with higher morbidity and mortality rates. Continuous renal replacement therapy (CRRT) is commonly employed to manage FO. In adults, both FO CRRT adversely affect myocardial function. It remains unclear if experience similar cardiovascular effects.
The impact of indication for pediatric liver transplantation on waitlist and post-transplant mortality outcomes is well known, but the intent-to-treat has not been investigated. Intent-to-treat survival analysis important in this study because it more comprehensive, combining transplant mortality, rate into a single metric to elucidate any disparities based indication.Cox regression was used analyze factors impacting 8,002 children listed UNOS database between 2006 2016. Kaplan-Meier method...
Abstract Background Children listed for heart transplantation face the highest waitlist mortality among all solid organ transplant patients (14%). Attempts at decreasing donor allograft non‐utilization (41.5%) could potentially decrease pediatric patients. Our aim was to quantify risk of allografts time initial offering. Methods Using United Network Organ Sharing (UNOS) database, we retrospectively analyzed 8823 deceased donors (≤18 years old) data through univariable and multivariable...
ABSTRACT Background Waitlist and posttransplant outcomes have been widely reported for pediatric liver transplantation. Yet, analyzing these metrics individually fails to provide a holistic perspective patients their families. Intent‐to‐treat (ITT) analysis fills this gap by studying the associations between waitlist outcomes, organ availability, outcomes. Our study aimed construct predictive index utilizing ITT transplant recipients (Pedi‐ITT). Methods We performed retrospective...
Smaglick, Michael; Goldman, Jordana; Kennedy, Curtis; Lang, Anna; Allen, Carl; McClain, Kenneth; Nguyen, Trung Author Information
1Department of Student Affairs, Baylor College Medicine, Houston, TX, USA 2Department Pediatrics, Division Nephrology, Texas Children's Hospital, 3Department Critical Care
1Baylor College of Medicine Texas Children's Hospital 2Baylor 3Texas 4Baylor at Childrens