A5017272011- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Respiratory viral infections research
- Dermatology and Skin Diseases
- Reproductive System and Pregnancy
- Inhalation and Respiratory Drug Delivery
- Food Allergy and Anaphylaxis Research
- Monoclonal and Polyclonal Antibodies Research
- Respiratory and Cough-Related Research
- Immune cells in cancer
- Bacterial Infections and Vaccines
- Breastfeeding Practices and Influences
- Air Quality and Health Impacts
- Vitamin D Research Studies
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Eosinophilic Esophagitis
The University of Western Australia
2015-2024
The Kids Research Institute Australia
2015-2024
The University of Queensland
2014-2024
Children's Medical Research Institute
2013-2019
Queensland Children’s Medical Research Institute
2014-2019
Princess Margaret Hospital for Children
1989-2019
Perth Children's Hospital
2019
Institute of Child Health
2019
Centre for Global Health Research
2002-2018
Inserm
2016
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract The expression of Th2-skewed immunity against soluble protein Ags present in the normal environment is recognized as primary cause allergic inflammation atopics. In contrast, nonallergic individuals display low level Th1-skewed same (“allergens”), which perceived conferring protection Th2-dependent sensitization. type T cell memory that develops these currently believed to be result complex interactions between environmental and genetic susceptibility factors, occur postnatally when...
Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma.The nature of potential interactions between these was the subject this study.A community-based cohort 198 children at high followed from birth to 5 years. All episodes acute illness in first year were recorded postnasal aspirates collected viral identification. History wheeze asthma annually, atopy assessed 6 months, 2 years, years.A total 815 reported, 33% LRIs....
Class II major histocompatibility complex (Ia)-bearing dendritic cells (DC) from airway epithelium and lung parenchyma express low-moderate antigen presenting cell (APC) activity when freshly isolated. However, this function is markedly upregulated during overnight culture in a manner analogous to epidermal Langerhans cells. The vitro "maturation" process inhibited by coculture with pulmonary alveolar macrophages (PAM) across semipermeable membrane, the degree of inhibition achieved can be...
<h3>Abstract</h3> <b>Objectives:</b> To investigate the association between duration of exclusive breast feeding and development asthma related outcomes in children at age 6 years. <b>Design:</b> Prospective cohort study. <b>Setting:</b> Western Australia. <b>Subjects:</b> 2187 ascertained through antenatal clinics major tertiary obstetric hospital Perth followed to <b>Main outcome measures:</b> Unconditional logistic regression model or atopy years age, allowing for several important...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity. However, the “default” response at mucosal surfaces demonstrates Th2 polarity, which is reflected cytokine profiles of activated lymph nodes. This study on rat respiratory tract DCs (RTDCs) provides an explanation this paradox. We demonstrate that freshly isolated RTDCs are functionally immature as defined vitro, being...
Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of immunologically mediated diseases. The present study demonstrates that macrophage-derived NO may conversely function to fine tune T cell-mediated inflammation via reversible dephosphorylation intracellular signaling molecules, which are involved the control cell proliferation. Thus, cells activated presence alveolar macrophages unable proliferate despite expression IL-2R and secretion IL-2. This process...
Although acute respiratory illnesses (ARI) are major causes of morbidity and mortality in early childhood worldwide, little progress has been made their control prophylaxis. Most studies have focused on hospitalized children or from closed populations. It is essential that the viral etiology these clinical diseases be accurately defined development antiviral drugs.To investigate role all common viruses as upper lower tract pathogens first year life.This community-based birth cohort study...
Indirect evidence implicates γδ T cells in the cross-regulation of CD4 αβ cell responses. Adoptive transfer small numbers from ovalbumin (OVA)-tolerant mice selectively suppressed H 2 -dependent immunoglobulin E(IgE) antibody production without affecting parallel IgG Challenge these vitro with specific antigen resulted high levels interferon γ. The effects may be mediated by direct inhibition OVA-specific + proliferation or selection for cells.
Immunohistochemical analysis of challenge sites such as skin and the peritoneal cavity has identified neutrophils virtually sole cellular participants in acute bacterial inflammation, peak influx occurring 24-48 h advance mononuclear cell populations associated with adaptive immunity. This study challenges general applicability this paradigm. We demonstrate here that earliest detectable response after inhalation Moraxella catarrhalis organisms is recruitment putative class II major...