A5087034786- Travel-related health issues
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Salmonella and Campylobacter epidemiology
- Trauma and Emergency Care Studies
- Antifungal resistance and susceptibility
- Disaster Response and Management
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- Escherichia coli research studies
- Fungal Infections and Studies
- Vaccine Coverage and Hesitancy
- Orthopedic Infections and Treatments
- Surgical site infection prevention
- Bacillus and Francisella bacterial research
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Climate Change and Health Impacts
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
Uniformed Services University of the Health Sciences
2016-2025
Unifor
2010-2023
Naval Medical Research Command
2005-2022
Joint Base San Antonio
2015-2022
Brooke Army Medical Center
2014-2022
General Dynamics (United States)
2022
United States Food and Drug Administration
2022
Henry M. Jackson Foundation
2015-2021
Walter Reed National Military Medical Center
1992-2020
Wilford Hall Ambulatory Surgical Center
2020
The rapid spread of the highly contagious Omicron variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) along with its high number mutations in spike gene has raised alarms about effectiveness current medical countermeasures. To address this concern, we measured neutralization BA.1 pseudovirus by postvaccination serum samples after two and three immunizations Pfizer/BioNTech162b2 SARS-CoV-2 mRNA (Pfizer/BNT162b2) vaccine, convalescent from unvaccinated individuals infected...
Importance Understanding the factors associated with post-COVID conditions is important for prevention. Objective To identify characteristics persistent post–COVID-19 symptoms and to describe medical encounters. Design, Setting, Participants This cohort study used data from Epidemiology, Immunology, Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) implemented in US military health system (MHS); MHS beneficiaries aged 18 years or older who tested...
Historically, non-combat injuries and illnesses have had a significant impact on military missions. We conducted an anonymous cross-sectional survey to assess the prevalence of common ailments among U.S. personnel deployed Iraq or Afghanistan during 2003-2004. Among 15,459 persons surveyed, diarrhea (76.8% in 54.4% Afghanistan), respiratory illness (69.1%), (34.7%), leishmaniasis (2.1%) were commonly reported. For all causes, 25.2% reported that they required intravenous fluids, 10.4%...
Major advances in combat casualty care have led to increased survival of patients with complex extremity trauma. Invasive fungal wound infections (IFIs) are an uncommon, but increasingly recognized, complication following trauma that require greater understanding risk factors and clinical findings reduce morbidity.The patient population includes US military personnel injured during from June 2009 through December 2010. Case definition required necrosis on successive debridements IFI evidence...
Background.Traveler's diarrhea in Thailand is frequently caused by Campylobacter jejuni. Rates of fluoroquinolone (FQ) resistance organisms have exceeded 85% recent years, and reduced efficacy has been observed.
Abstract Background The relationship between postvaccination symptoms and strength of antibody responses is unclear. goal this study was to determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated magnitude vaccine-induced levels. Methods We conducted a single-center, observational cohort consisting generally healthy adult participants that were not severely immunocompromised, had no history coronavirus disease 2019, seronegative for...
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, both. We measured their neutralization titers against 15 natural and 7 engineered spike mutations analyzed antigenic diversity. Antigenic maps primary sera showed that Omicron sublineages BA.2, BA.4/BA.5, BA.2.12.1 are distinct BA.1 more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations...
Abstract Background Comparison of humoral responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinees, those with SARS-CoV-2 infection, or combinations vaccine/ infection (“hybrid immunity”) may clarify predictors vaccine immunogenicity. Methods We studied 2660 US Military Health System beneficiaries a history infection-alone (n = 705), vaccination-alone 932), vaccine-after-infection 869), and vaccine-breakthrough-infection 154). Peak anti-spike–immunoglobulin G (IgG)...
ABSTRACT Introduction Vaccine mandates have been used to minimize the duty days lost and deaths attributable infectious disease among active Service members (ADSMs). In response global COVID-19 pandemic, in August 2021, U.S. DoD issued a vaccine mandate for all ADSMs. This study aimed investigate uptake ADSM population, as well factors associated with timing of receipt. Materials Methods included ADSMs on between January 1, 2020, June 30, 2022. Univariate analyses investigated associations...
Abstract Objective: Characterization and assessment of Department Defense’s (DoD’s) Antibiotic Stewardship Programs (ASPs) to determine adherence Centers for Disease Control Prevention (CDC) Core Elements compare national Design: Retrospective, observational with supplemental survey Methods: Facility characteristics CDC (CE) data 2017–2021 were retrieved from the National Healthcare Safety Network’s (NHSN) annual hospital DoD Defense Health Agency Resistance Patient Portal. An online was...
Functional gastrointestinal disorders (FGDs) are recognized sequelae of infectious gastroenteritis (IGE). Within the active duty military population, a group with known high IGE rates, population-based incidence, risk factors, and attributable burden care referable to FGD after poorly defined.Using electronic medical encounter data (1999-2007) on US military, matched, case-control study describing epidemiology determinants (irritable bowel syndrome (IBS), functional constipation (FC),...
ABSTRACT A human Campylobacter jejuni infection model provided controlled exposure to assess vaccine efficacy and investigate protective immunity for this important diarrheal pathogen. well-characterized outbreak strain, C. 81-176, was investigated using a volunteer experimental evaluate the dose range duration of protection. Healthy -seronegative adults received strain 81-176 via oral inoculation 10 5 , 7 or 9 CFU (5 adults/dose), which followed by clinical immunological monitoring. Based...
Complex traumatic injuries sustained by military personnel, particularly when involving extremities, often result in infectious complications and substantial morbidity. One factor that may further impair patient recovery is the persistence of infections. Surface-attached microbial communities, known as biofilms, play a role hindering management infections; however, clinical data associating biofilm formation with persistent or chronic infections are lacking. Therefore, we evaluated...
During the conflicts in Iraq and Afghanistan, more than 52,000 U.S. military members were wounded action. The battlefield mortality rate was lower past conflicts, however, those surviving often had complex soft tissue bone injuries requiring multiple surgeries. This report describes rates, types, risks of infections complicating care combat casualties.Infection microbiology data obtained from Trauma Infectious Disease Outcomes Study (TIDOS), a prospective observational study...