A5101983517- Acute Ischemic Stroke Management
- Data Quality and Management
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Data Mining Algorithms and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Database Systems and Queries
- Big Data and Business Intelligence
- Mycobacterium research and diagnosis
- Microtubule and mitosis dynamics
- Semantic Web and Ontologies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Data Management and Algorithms
- Indoor and Outdoor Localization Technologies
- Viral Infections and Immunology Research
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Music History and Culture
- Immune Response and Inflammation
- Integrated Circuits and Semiconductor Failure Analysis
Johns Hopkins University
2012-2025
Imperial College London
2017-2025
Johns Hopkins Medicine
2020-2024
University of Miami
2023-2024
Center for Biologics Evaluation and Research
2021-2024
United States Food and Drug Administration
2021-2024
Johns Hopkins Hospital
2022-2024
University of Saskatchewan
2024
New York Medical College
2024
Cooper Medical School of Rowan University
2024
Many of the concepts and procedures product quality control can be applied to problem producing better information outputs. From this perspective, outputs viewed as products, many systems modeled manufacturing systems. The use products is becoming increasingly prevalent both within across organizational boundaries. This paper presents a set ideas, concepts, models, appropriate that used determine delivered, or transferred, customers. These produce on regular as-requested basis. model...
Rationale: Mitochondria are semiautonomous cellular organelles with their own genome, which not only supply energy but also participate in cell death pathways. MicroRNAs (miRNAs) usually 19 to 25 nt long, noncoding RNAs, involved posttranscriptional gene regulation by binding the 3′-untranslated regions of target mRNA, impact on diverse processes. Objective: To determine if nuclear miRNAs translocate into mitochondria and regulate mitochondrial function possible pathophysiological...
The role of CD8 T cells in anti-tuberculosis immunity humans remains unknown, and studies cell–mediated protection against tuberculosis mice have yielded controversial results. Unlike mice, nonhuman primates share a number important features the immune system that relate directly to specificity functions cells, such as expression group 1 CD1 proteins are capable presenting Mycobacterium lipids antigens cytotoxic/bactericidal protein granulysin. Employing more relevant primate model human...
Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as quantitative trait loci (eQTLs), may improve understanding the functional role phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes some previous eQTL have limited their statistical power. We conducted an investigation microarray-based and exon levels whole blood a cohort 5257 individuals, exceeding size by more than factor 2.We detected over 19,000...
3D soft bioscaffolds have great promise in tissue engineering, biohybrid robotics, and organ-on-a-chip engineering applications. Though emerging three-dimensional (3D) printing techniques offer versatility for assembling biomaterials, challenges persist overcoming the deformation or collapse of delicate structures during fabrication, especially overhanging thin features. This study introduces a magnet-assisted fabrication strategy that uses magnetic field to trigger shape morphing provide...
Clozapine is an atypical antipsychotic drug with reduced risk of unwanted neurological effects in comparison other drugs. In this multicenter study, 151 hospitalized schizophrenic patients were randomly assigned to treatment under double-blind conditions assess the efficacy and safety clozapine versus chlorproma-zine. All exhibited tardive dyskinesia or extrapyramidal side associated at least two prior neuroleptics. Eleven dropped from due extrapyra-midal symptoms while being treated...
Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) 68 101 patients (67%) by nested PCR, as compared with 8 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any (MLV)-related gene sequences CFS patients. We examined 41 PBMC-derived samples 37 meeting accepted diagnostic criteria for and found MLV-like...
Objective— Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene–disease associations, however, remain unclear. We hypothesized that genetic variants both strong and subtle effects drive gene subnetworks in turn affect CHD. Approach Results— surveyed CHD-associated interactions by constructing coexpression networks using whole blood expression profiles from 188 cases age- sex-matched controls. Twenty-four...
Governments and foundations have successfully harnessed tournaments to spur innovation. Yet this tool is not widely used by firms. This article presents a framework for managers seeking organize ideas. It examines the theoretical underpinnings of then connects analysis with three recent innovations—the power network, wisdom crowds, love—that can boost effectiveness tournaments.
Objective— To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and age- sex-matched controls who were participants the Framingham Heart Study. Approach Results— A total 35 genes differentially expressed versus at false discovery rate<0.5, including GZMB , TMEM56 GUK1 . Cluster analysis revealed 3 gene clusters associated CHD, 2 linked to increased erythrocyte production a third reduced natural killer T cell activity CHD. Exon-level results...
Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of T cells tuberculosis remains unknown. We conducted mechanistic studies to determine whether earlier expansion/differentiation during Mtb infection could increase immune resistance macaques. Phosphoantigen/IL-2 administration specifically induced major expansion pulmonary trafficking/accumulation phosphoantigen-specific cells,...
Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. However, understanding the mode of action cell therapy has been limited by tracking capability correlation between pharmacokinetics injected intended pharmacodynamics effect. This study aims to explore methodology understand vivo biodistribution clinical-grade haMSCs labeled with fluorescent dye into an immunocompetent...
Genome-wide association studies (GWAS) have identified numerous loci associated with blood pressure (BP). The molecular mechanisms underlying BP regulation, however, remain unclear. We investigated BP-associated by integrating GWAS whole mRNA expression profiles in 3,679 individuals, using network approaches. transcriptomic signatures at the single-gene and coexpression module levels were identified. Four modules as potentially causal based on genetic inference because expression-related...
Abstract Pathogenesis hallmarks for tuberculosis (TB) are the Mycobacterium (Mtb) escape from phagolysosomal destruction and limited drug delivery into infected cells. Several nanomaterials can be entrapped in lysosomes, but development of functional to promote Mtb clearance remains a big challenge. Here, we report on bactericidal effects selenium nanoparticles (Se NPs) against further introduce novel nanomaterial‐assisted anti‐TB strategy manipulating Ison@Man‐Se NPs synergistic...
Significance Despite the urgent need for a better tuberculosis (TB) vaccine, relevant protective mechanisms remain unknown. We previously defined phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP)–specific Vγ2Vδ2 T cells as unique subset in primates, and, here, we immunized them selectively protection against TB. A single respiratory vaccination of macaques with attenuated HMBPP-producing Listeria monocytogenes (Lm ΔactA prfA *), but not an HMBPP-lacking ΔgcpE strain,...
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, both. We measured their neutralization titers against 15 natural and 7 engineered spike mutations analyzed antigenic diversity. Antigenic maps primary sera showed that Omicron sublineages BA.2, BA.4/BA.5, BA.2.12.1 are distinct BA.1 more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations...
Soft actuators (SAs) are devices which can interact with delicate objects in a manner not achievable traditional robotics. While it is possible to design SA whose actuation triggered via an external stimulus, the use of single stimulus creates challenges spatial and temporal control actuation. Herein, 4D printed multimaterial soft actuator (MMSA) only initiated by combination triggers (i.e., pH temperature) presented. Using 3D printing, multilayered hydrophilic pH-sensitive layer,...
Pretreatment CT Perfusion (CTP) parameter rCBV < 42% lesion volume has recently been shown to predict 90-day mRS. In this study, we aim assess the relationship between and a radiographic follow-up infarct delineated on FLAIR images. retrospective evaluation of our prospectively collected database, included acute stroke patients triaged by multimodal imaging, including angiography perfusion with confirmed anterior circulation large vessel occlusion 9 January 2017 10 2023. Follow-up imaging...
Abstract Conductive polymers hold promise in biomedical applications owing to their distinct conductivity characteristics and unique properties. However, incorporating these into biomaterials poses challenges related mechanical performance, electrical stability, biodegradation. This study proposes an injectable hydrogel scaffold composed of a self‐doped conductive polymer, constituted sulfated glycosaminoglycan (GAG) with side chains PEDOT (poly 3,4‐ethylenedioxythiophene). brush copolymer...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic ground states of manganocene and 1,1'-dimethylmanganoceneMary E. Switzer, Richard Wang, Michael F. Rettig, August H. MakiCite this: J. Am. Chem. Soc. 1974, 96, 25, 7669–7674Publication Date (Print):December 1, 1974Publication History Published online1 May 2002Published inissue 1 December 1974https://pubs.acs.org/doi/10.1021/ja00832a012https://doi.org/10.1021/ja00832a012research-articleACS PublicationsRequest reuse permissionsArticle...