A5052008214- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Multiple Myeloma Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Herpesvirus Infections and Treatments
New York Medical College
2016-2025
Westchester Medical Center
2013-2025
Shenyang Anorectal Hospital
2024-2025
Northwest A&F University
2025
Jining University
2025
Hunan Normal University
2021-2024
Hunan Provincial People's Hospital
2020-2024
First Affiliated Hospital of Zhengzhou University
2015-2024
Beijing University of Posts and Telecommunications
2024
National Heart Lung and Blood Institute
2010-2023
In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% patients, usually many months years after diagnosis anemia.
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. classified as type I protein, with single domain, cytoplasmic C-terminus, and extracellular N-terminus. biomarker for normal neoplastic B cells, well follicular dendritic cells. critically involved in establishing intrinsic cell signaling thresholds through modulating both receptor-dependent independent signaling. functions dominant component of multimolecular complex on surface mature...
Rationale: Mitochondria are semiautonomous cellular organelles with their own genome, which not only supply energy but also participate in cell death pathways. MicroRNAs (miRNAs) usually 19 to 25 nt long, noncoding RNAs, involved posttranscriptional gene regulation by binding the 3′-untranslated regions of target mRNA, impact on diverse processes. Objective: To determine if nuclear miRNAs translocate into mitochondria and regulate mitochondrial function possible pathophysiological...
Abstract Background Liposomal formulations of anthracyclines appear to have favorable toxicity profile when compared with conventional in elderly, high risk cardiac patients and prior use anthracyclines. Randomized controlled trials evaluated the efficacy safety liposomal Our aim is evaluate adverse effects quantify relative through meta-analysis published randomized trials. Methods We conducted a broad search strategy major electronic databases. performed meta- analysis on comparing...
Abstract Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle intermediates, have been reported to play critical roles pluripotency. Here we show that TCA enzymes Pdha1, Pcb, Aco2, Cs, Idh3a, Ogdh, Sdha Mdh2 are translocated the nucleus during somatic cell reprogramming, primed-to-naive transition totipotency acquisition. The nuclear-localized Idh3a promote reprogramming...
JAK-STAT (Janus associated kinase-signal transducer and activator of transcription) pathway plays a critical role in transduction extracellular signals from cytokines growth factors involved hematopoiesis, immune regulation, fertility, lactation, embryogenesis. JAK family contains four cytoplasmic tyrosine kinases, JAK1-3 Tyk2. Seven STAT proteins have been identified human cells, STAT1-6, including STAT5a STAT5b. Negative regulators pathways include phosphatases (SHP1 2, CD45), protein...