A5037071948- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Vector-Borne Animal Diseases
- Venous Thromboembolism Diagnosis and Management
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Clinical Reasoning and Diagnostic Skills
- Vitamin K Research Studies
- Prenatal Substance Exposure Effects
- Multiple Myeloma Research and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Synthesis of β-Lactam Compounds
- Ubiquitin and proteasome pathways
- Long-Term Effects of COVID-19
- Erythrocyte Function and Pathophysiology
- Protein Tyrosine Phosphatases
- Gestational Diabetes Research and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Healthcare Operations and Scheduling Optimization
- Bladder and Urothelial Cancer Treatments
St. Francis Hospital
2022
SUNY Downstate Health Sciences University
2013-2016
New York Oncology Hematology
2015
University of British Columbia
2015
New York Medical College
2012-2014
Westchester Medical Center
2012-2014
State University of New York
2014
JAK-STAT (Janus associated kinase-signal transducer and activator of transcription) pathway plays a critical role in transduction extracellular signals from cytokines growth factors involved hematopoiesis, immune regulation, fertility, lactation, embryogenesis. JAK family contains four cytoplasmic tyrosine kinases, JAK1-3 Tyk2. Seven STAT proteins have been identified human cells, STAT1-6, including STAT5a STAT5b. Negative regulators pathways include phosphatases (SHP1 2, CD45), protein...
Multiple myeloma (MM) is a neoplasm of plasma cells within the bone marrow. A major impact on improving survival in MM has been use boronic acid-derived proteasome inhibitor bortezomib, first-in-class selective 26S proteasome. Ocular side effects bortezomib are rare. In this report, we present 2 patients with active whom persistent chalazia became therapy-interfering complication treatment bortezomib. Both had relapsed ISS III B kappa light chain myeloma, and they were responding to until -...
Carboxylation of glutamic acid residues vitamin K dependent clotting factors (II, VII, IX, and X) is essential to their biological functioning. Binding these γ-glutamyl carboxylase enzyme for carboxylation reaction mediated by wild-type propeptide, a small sequence amino acids that precede the actual polypeptide. Missense mutations at certain residue severely decrease affinity mutated propeptide enzyme. Such are reported occur codon-10 factor IX clinically silent metabolic event in normal...
The clinician arriving at the hospital in morning may not yet be aware of key overnight clinical activity. To address this situation our facility, we modified handoff software to permit continuous updating information and automatic relay important updates relevant providers each morning.Cross-covering residents electronically entered safety concerns issues within reporting module between 5 PM 7 AM. This updated their handoff-information shift change permitted generation reports that were...
A 57-year-old gentleman presented to the hospital with progressive fatigue and dyspnea on exertion three months after recovering from COVID-19. He was noted have severe anemia reticulocytopenia. After excluding vitamin deficiencies heavy metal toxicities, a bone marrow aspirate biopsy were performed, which showed erythroid predominant trilineage maturing hematopoiesis 79% ring sideroblasts no dysplasia. SF3B1 mutation negative. diagnosed sideroblastic became transfusion-dependent. treated an...
Restricted accessAbstractFirst published online February 1, 2016Role of Histone Deactylase (Hdac) Inhibitors in adult T-Cell Lymphoma/Leukemia (Atl)N Mukhi, G Sidhu, […], J Gonsky, and I Shapira+1-1View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.15
Restricted accessAbstractFirst published online February 1, 2016Adult t Cell Lymphoma (Atl) Masquerading as Facial nerve ParalysisN Mukhi, J Park, […], P Draksharam, G Sidhu, and I Shapira+2-2View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.51
e19527 Background: ATLL is an aggressive T cell lymphoma (TCL) associated with HTLV1 infections, endemic to certain regions. The acute and lymphomatous types have the poorest prognoses of any TCL, their responses standard therapy CHOP, are brief. Methods: Charts patients at Kings County Hospital in Brooklyn, NY from 2002-14 were retrospectively reviewed. They treated EPOCH, had serology positive for Results: Records 43 reviewed, 34females 23males. Median age diagnosis was 54 years (range...
Restricted accessAbstractFirst published online February 1, 2016Circulating Mirna Profiles point to Dysregulation in Tgfbeta/smad3 Tumor Suppressor Signature Brca Positive Breast Cancer PatientsI Shapira, T Bhuiya, […], S Arora, N Mukhi, Datla, E Neculiseanu, C Mason, A Shih, and Lee+6-6View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.44
e15622 Background: Transitional cell cancer (TCC) of renal pelvis (RP) is an uncommon malignancy the urinary tract. The standard treatment radical nephro-uretrectomy (NU) with bladder cuff resection whereas lesser extensive surgeries preservation are recommended for situations like solitary kidney, bilateral disease, or insufficiency. Role radiation unclear. Methods: We reviewed data from Surveillance, Epidemiology, and End Results (SEER) Data registry patients TCC RP 1973 to 2010. Results:...