Milissa U Jones
A5102980459- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Biosensors and Analytical Detection
- Maternal Mental Health During Pregnancy and Postpartum
- SARS-CoV-2 detection and testing
- vaccines and immunoinformatics approaches
- HIV, Drug Use, Sexual Risk
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Food Security and Health in Diverse Populations
- Immune responses and vaccinations
- Exercise and Physiological Responses
- Infection Control in Healthcare
- Workplace Violence and Bullying
Uniformed Services University of the Health Sciences
2019-2025
Unifor
2023
Tripler Army Medical Center
2022
Walter Reed National Military Medical Center
2017-2018
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, both. We measured their neutralization titers against 15 natural and 7 engineered spike mutations analyzed antigenic diversity. Antigenic maps primary sera showed that Omicron sublineages BA.2, BA.4/BA.5, BA.2.12.1 are distinct BA.1 more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations...
Abstract Background Comparison of humoral responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinees, those with SARS-CoV-2 infection, or combinations vaccine/ infection (“hybrid immunity”) may clarify predictors vaccine immunogenicity. Methods We studied 2660 US Military Health System beneficiaries a history infection-alone (n = 705), vaccination-alone 932), vaccine-after-infection 869), and vaccine-breakthrough-infection 154). Peak anti-spike–immunoglobulin G (IgG)...
Characterizing the longevity and quality of cellular immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding disease 2019 (COVID-19) immunity that influences clinical outcomes. Prior studies suggest SARS-CoV-2-specific T cells are present in peripheral blood 10 months after infection. Analysis function, durability, diversity response long natural infection, over a range ages phenotypes, is needed identify preventative therapeutic...
Abstract Background The impact of SARS-CoV-2 infection and vaccination on menstruation is unclear. goal this study to quantify the relationships between history incident, clinically documented menstrual irregularities using data from EPICC in Military Health System (MHS) beneficiaries.Figure 1.Odds associated with having been infected or vaccinated against certain timeframes (30, 90, 180, 365 days prior diagnosis matched timepoint), after controlling for comorbidities cases controls...
Abstract Background While current viral detection methods demonstrate high sensitivity, their clinical relevance remains inexact. We evaluated the prevalence of respiratory pathogen (RVPD) using multiplex polymerase chain reaction (M-PCR) and its correlation with nasal immune cell quantities reported symptoms (RVS) in asymptomatic or pauci-symptomatic children. Demographic Clinical Characteristics 20 Children at Enrollment Pediatric Respiratory Co-infection Immunologic Response Study (Peds...
Background Knowledge of HIV risk factors and reduction strategies is essential for prevention in key populations such as men who have sex with (MSM) transgender women (TGW). We evaluated associated HIV-related knowledge among MSM TGW the impact engagement care at trusted community health centers Nigeria. Methods The TRUST/RV368 cohort recruited Lagos Abuja, Nigeria via respondent driven sampling. During study visits every three months, participants underwent structured interviews to collect...
Patient-reported outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are an important measure the full burden disease (COVID). Here, we examine how (1) infecting genotype and COVID-19 vaccination correlate with inFLUenza Patient-Reported Outcome (FLU-PRO) Plus score, including by symptom domains, (2) FLU-PRO scores predict return to usual activities health.The epidemiology, immunology, clinical characteristics pandemic infectious diseases (EPICC) study was...
The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact vaccination that relationship is uncertain. We compared survey responses in a 1-year study US military service members with (n = 1923) without 1591) history severe acute respiratory syndrome 2 (SARS-CoV-2) infection. fit Poisson regression models to estimate association between SARS-CoV-2 infection impairment, adjusting for time since infection, demographics, baseline health....
Abstract Coronavirus disease 2019 (COVID-19) vaccine breakthrough infections have been important for all circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant periods, but the contribution of vaccine-specific SARS-CoV-2 viral diversification to failure remains unclear. This study analyzed 595 sequences collected from Military Health System beneficiaries between December 2020 and April 2022 investigate impact vaccination on diversity. By comparing based status...
ABSTRACT Antigen-based rapid diagnostic tests (Ag-RDTs) provide timely results, are simple to use, and less expensive than molecular assays. Recent studies suggest that antigen-based testing aligns with virus culture-based results (a proxy of contagiousness at the peak viral phase illness); however, performance Ag-RDTs for newer SARS-CoV-2 variants is unclear. In this study, we (i) assessed antibodies detect a range (ii) determined whether Ag-RDT correlated culture positivity. We noted only...
Abstract Background: SARS-CoV-2 most severely affects older age groups, while children experience minimal disease. We measured elements of adaptive immunity in and adults with to define the age-dependent viral host response. Methods: Participants were enrolled Epidemiology, Immunology, Clinical Characteristics Emerging Infectious Diseases Pandemic Potential (EPICC) study. Eligibility required that individuals present COVID-19-like symptoms between March 2020 2022. Magnitude RNA was...
Abstract Background Predicting, preventing, and treating post-COVID condition (PCC; “Long COVID) is challenging due to a limited understanding of PCC mechanisms. To address this, we analyzed whole blood transcriptomic data using machine learning identify candidate gene expression pathways associated with the development PCC. Figure 1 (A) Clinical demographic characteristics 222 military health system beneficiaries (COVI D, no PCC: SARS-CoV-2 positive subjects reported or mild symptoms on...
Abstract Background SARS-CoV-2 infections have been associated with self-reported impaired cognitive function, but research examining objective assessments is scant. Given the potential impact of long-term impairment, it important to characterize this post-infection phenotype. Methods The Epidemiology, Immunology, and Clinical Characteristics Emerging Infectious Diseases Pandemic Potential (EPICC) study a longitudinal cohort assessing infection in Military Health System (MHS) beneficiaries....
Abstract Background Defining the magnitude and quality of antibodies induced by infection vaccination for SARS-CoV-2 during pregnancy that cross placenta can improve strategies to protect both mothers infants. Methods Maternal peripheral neonatal cord blood were collected from participants enrolled in a prospective longitudinal cohort study, Epidemiology, Immunology, Clinical Characteristics pathogens with pandemic potential (EPICC), after presenting military treatment facility between March...
In the US, rates of perinatal transmission HIV have fallen dramatically since start epidemic. The declining been attributed to key interventions, which pediatric providers should be familiar. Annually, very few mothers infected with give birth at our institution. Such limited exposure may affect providers’ ability stay aware current guidelines as well maintain their comfort level when caring for infants born positive mothers. We sought assess both knowledge prevent HIV, pediatrics had care...
Abstract Background Knowledge of HIV risk factors and reduction strategies is essential for prevention in key populations, including men who have sex with (MSM) transgender women (TGW). We described associated HIV-related knowledge evaluated the impact counseling care at trusted community health centers serving Nigerian MSM TGW. Methods The TRUST/RV368 cohort recruits TGW via respondent driven sampling Abuja Lagos, Nigeria. Participants undergo a structured interview five knowledge-testing...
TOKARS, J. I.; CHAMBERLAND, M. E.; SCHABLE, C. A.; CULVER, D. H.; JONES, M.; McKIBBEN, P. S.; BELL,
Abstract Background In Sub-Saharan African (SSA) women living with HIV, pregnancy creates unique stressors that may induce or exacerbate depression. We described the prevalence of depression during perinatal period among HIV became pregnant (P-WLWH) as compared those did not (NP-WLWH). Methods analyzed data from WLWH, age < 45 years, across 11 clinics in Kenya, Nigeria, Uganda, and Tanzania, within Cohort Study (AFRICOS). Depression screening was performed via Center for Epidemiological...