A5017039036- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Occupational Health and Performance
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Voice and Speech Disorders
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Genetic Neurodegenerative Diseases
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Occupational and environmental lung diseases
- COVID-19 Clinical Research Studies
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Renal cell carcinoma treatment
- Eosinophilic Disorders and Syndromes
- Sarcoidosis and Beryllium Toxicity Research
- Pediatric health and respiratory diseases
Memorial Sloan Kettering Cancer Center
2025
Joint Base San Antonio
2012-2024
Brooke Army Medical Center
2015-2024
Banner - University Medical Center Phoenix
2022-2024
Thomas Jefferson University Hospital
2024
Wilford Hall Ambulatory Surgical Center
2011-2023
San Antonio Uniformed Services Health Education Consortium
2012-2023
Thomas Jefferson University
2023
Thrive
2023
University of Florida
1997-2021
Methods to examine sputum for indices of airway inflammation are evolving. We have examined the repeatability and validity an improved method measure cells fluid-phase eosinophil cationic protein (ECP), major basic (MBP), eosinophil-derived neurotoxin (EDN), albumin, fibrinogen, tryptase, interleukin-5 (IL-5). Sputum was induced with hypertonic saline twice within 6 d in 10 healthy subjects, 19 stable asthmatics, smokers nonobstructive bronchitis. The included processing freshly expectorated...
Importance Understanding the factors associated with post-COVID conditions is important for prevention. Objective To identify characteristics persistent post–COVID-19 symptoms and to describe medical encounters. Design, Setting, Participants This cohort study used data from Epidemiology, Immunology, Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) implemented in US military health system (MHS); MHS beneficiaries aged 18 years or older who tested...
The role of inhaled corticosteroids in the management chronic obstructive pulmonary disease (COPD) remains controversial. purpose this study was to evaluate whether sputum eosinophilia (defined as eosinophils > or = 3%) predicts clinical benefit from corticosteroid treatment patients with smoking-related clinically stable moderate-to-severe COPD. Forty consecutive effort dyspnoea (mean age 67 yrs; 52 pack-yr smoking history; post-bronchodilator forced expiratory volume one second (FEV1) <60%...
The reproducibility of sputum cell counts was examined and the in patients with asthma were compared those chronic bronchitis. Three groups subjects studied. Sputum from eight production studied to determine counts. findings 10 non-smokers uncomplicated by other airway disease at time an exacerbation (group 2) smokers cough but no features 3). plugs selected microscopy ensure their origin lower respiratory tract. A total count performed on a trypsinised suspension, differential metachromatic...
The response to inhaled methacholine is increased in patients with chronic airflow obstruction, but it not known whether this due true hyperresponsiveness or a result of the obstruction. In asthmatics correlates bronchoconstriction produced by hyperventilation cold dry air. We studied 27 history smoking and bronchitis range severity Bronchial responses (expressed as provocation concentration causing fall FEV1 20%-PC20) isocapnic air were measured. 19 PC20 was less than 8 mg/ml (that is,...
Tidal expiratory flow pattern was analysed in 99 subjects with a view to assessing it as quantitative measurement of airflow obstruction. Fifteen normal volunteers, nine patients dyspnoea referred for investigation whom airway resistance within limits, 24 restrictive lung disorders, and 51 obstruction were studied. The against time had quadrilateral configuration obstruction, which differed from the more sinusoidal form that is seen without rapid rise tidal peak two ways, percentage volume...
Since 2001, more than 2.7 million U.S. military personnel have been deployed in support of operations Southwest Asia and Afghanistan. Land-based experienced elevated exposures to particulate matter other inhalational from multiple sources, including desert dust, burn pit combustion, industrial, mobile, or sources. A workshop conducted at the 2018 American Thoracic Society International Conference had goals of: 1) identifying key studies assessing postdeployment respiratory health, 2)...
TPS289 Background: Prostate specific membrane antigen (PSMA) is a validated target in metastatic castration resistant prostate cancer (CRPC). Use of an alpha emitter as radionuclide and high affinity monoclonal antibody for protein targeting PSMA-targeted radiopharmaceutical therapy (TRT) offer the promise improved precision potency compared to alternative approaches. Ac-225 rosopatamab tetraxetan (CONV01-ɑ, formerly Ac-225-J591) has been evaluated safety efficacy sequential...
Summary The purpose of this study was to examine airway responsiveness, sputum cells and the effects inhaled corticosteroid in chronic cough syndrome associated with eosinophilic bronchitis. We studied nine consecutive referrals cough, >10% eosinophils, normal spirometry, methacholine responsiveness. Clinical assessment, analysis, allergy skin tests a inhalation test were performed at first visit. Peak expiratory flow (PEF) measured twice daily for 1 week followed by an adenosine...
To investigate the clinical activity of combination bleomycin, etoposide, and cisplatin for metastatic ovarian sex cord-stromal tumors all types poorly differentiated Sertoli-Leydig cell confined to ovary. The regimen was administered as follows: bleomycin 10–15 mg/day by continuous intravenous (IV) infusion on days 1–3; etoposide 100 mg/m2 IV per day 1-3; 1. End points analysis included response, progression-free survival, survival. Nine patients were entered in this trial. median age 37...
Summary Circulating eosinophils, basophils and eosinophil/basophil (Eo/B) progenitors were examined in 12 patients at the time of an exacerbation asthma accompanied by sputum eosinophilia after resolution with inhaled corticosteroid treatment. Differential counts performed peripheral blood non‐adherent mononuclear cells cultured for 14 days methyl‐cellulose to determine number Eo/B granulocyte‐macrophage (GM) colonies without knowledge clinical conditions or findings. With on beclomethasone...
In Brief Vocal cord dysfunction, a syndrome of paradoxical inspiratory closure the vocal cords, is becoming more frequently recognized and diagnosed recently since its initial modern description 30 years ago. Initially described as single case reports, first series in 1983 helped to clarify typical patient findings dysfunction. Recent investigations have elucidated specific etiologies such gastroesophageal reflux, exercise, irritants causative factors addition numerous associated psychologic...
Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better lung-replacement approaches. We investigated ability novel extracorporeal venovenous CO2 removal device reduce minute while maintaining normocarbia.Prospective animal study.Government laboratory intensive care unit.Seven sedated swine.Tracheostomy, volume-controlled mechanical ventilation, and 72 hrs round-the-clock unit care. A 15-F dual-lumen...
Because of increased levels airborne particulate matter in Southwest Asia, deployed military personnel are at risk for developing acute and chronic lung diseases. Increased respiratory symptoms reported, but limited data exist on reported diseases.To evaluate new complaints returning from Asia to determine potential etiologies symptoms.Returning underwent a prospective standardized evaluation deployment-related within 6 months their duty station.Prospective included full pulmonary function...
Obstructive lung diseases in the lower airways are a leading health concern worldwide. To improve our understanding of pathophysiology airways, we studied airflow characteristics between 8th and 14th generations using three-dimensional computational fluid dynamics model, where compared normal obstructed for range breathing conditions. We employed novel technique based on computing Pearson׳s correlation coefficient to quantitatively characterize differences patterns airways. found that...
To evaluate the treatment and outcome of patients with adenocarcinoma in situ cervix, special emphasis on cone biopsy margins. Sixty-one women cervix treated between April 1984 December 1993 were identified. Medical records histologic material reviewed. Mixed lesions both squamous cervical intraepithelial neoplasia (CIN) included. The mean age was 35.9 years. Fifty-five 61 (90%) had biopsies, 44 these 55 (80%) subsequently hysterectomies. Eight (13%) associated invasive cancer. Among 50 whom...
In a previous study on 27 patients with chronic bronchitis we found that only three developed bronchoconstriction in response to hyperventilation of cold, dry air despite an increased responsiveness methacholine inhalation. We therefore investigated bronchial and stable asthma who had similar range baseline FEV1 values but could be reversed give more than 70% the predicted value. Baseline was 0.88-3.98 l (37-114% predicted). All one subject hyperventilation. There linear relationship between...