A5036884729- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Breast Cancer Treatment Studies
- Chronic Kidney Disease and Diabetes
- Autoimmune and Inflammatory Disorders
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Liver Diseases and Immunity
- Vasculitis and related conditions
- HER2/EGFR in Cancer Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Risks and Factors
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Clinical Research Studies
- Ovarian function and disorders
- Autoimmune Bullous Skin Diseases
- Estrogen and related hormone effects
- Abdominal Surgery and Complications
- Diabetes and associated disorders
- Reproductive Biology and Fertility
- Chemotherapy-induced organ toxicity mitigation
- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
King Saud University
2014-2024
King Saud Medical City
2023
King Khalid University Hospital
2009-2019
Majmaah University
2018
University of Ha'il
2018
Qassim University
2018
King Khalid University
2015
University of Alberta
2012-2014
The Metabolomics Innovation Centre
2012
Cisplatin (CP) is commonly used in the treatment of different types cancer but nephrotoxicity has been a major limiting factor. Therefore, present study aimed to possible protective effect rutin against induced by cisplatin rats. Forty male Wistar albino rats were randomly divided into 4 groups. Rats group 1 control intraperitoneal (i.p.) received 2.5 ml/kg, 2 CP single dose 5 mg/kg i.p. 3 orally 30 (CP plus rutin) and as 3. Kidneys harvested for histopathology gene expression c-Jun...
Standard clinical and laboratory parameters have limited predictive values for discriminating between active lupus nephritis chronic disease. The objective of this study was to examine the utility a second kidney biopsy in patients with nephritis.Patients were advised biopsies at end maintenance phase their therapies. Baseline renal re-classified by pathologists blinded data. relationships remission status histological examined.Included 77 followed up median duration 8.7 years (interquartile...
Characterizing the longevity and quality of cellular immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding disease 2019 (COVID-19) immunity that influences clinical outcomes. Prior studies suggest SARS-CoV-2-specific T cells are present in peripheral blood 10 months after infection. Analysis function, durability, diversity response long natural infection, over a range ages phenotypes, is needed identify preventative therapeutic...
To determine the pattern of breast diseases among Saudi patients who underwent biopsy, with special emphasis on carcinoma.A retrospective review was made all biopsy reports a mass or lump from male and female seen between January 2001 December 2010 at King Khalid University Hospital, Riyadh, Arabia.Of 1035 tissues reviewed, 939 specimens (90.7%) were patients. There 690 benign (65.8%) 345 (34.2%) malignant cases. In women, 603 (64.2%) 336 (35.8%) malignant. men, 87 (90.6%) 9 (9.4%) All cases...
The immunobiology of breast cancer (BC) subtypes, including luminal cancer, remains unclear. Cluster differentiation (CD)8+ tumor‑infiltrating lymphocytes (TIL) are essential components tumor‑specific cellular adaptive immunity. However, only few studies have addressed the significance cluster 8+(CD8+) TIL in patients with BC. present study aimed to evaluate predictive and prognostic CD8+ B/human epidermal growth factor receptor 2 (HER 2)‑negative BC treated anthracycline‑based neoadjuvant...
To determine the distribution of various molecular subtypes breast cancer in Saudi Arabia and to assess association between these age at diagnosis, tumor size, histopathological type, grade, presence carcinoma in-situ, lymph node status. This observational retrospective study, January 2010 December 2014, was conducted King Khalid University Hospital, Riyadh, Arabia. We classified 359 cancers into 4 subtypes, using immunohistochemistry: luminal A (estrogen receptor [ER], or progesterone [PR]...
Diabetes Mellitus during wound healing alters macrophage recruitment, leading to delayed healing. The present study focuses on impact of camel milk peptide (CMP) plasticity their recruitment stages. Swiss albino rats were distributed into three groups: a normal wounded group (control), diabetic group, and treated with CMP daily. showed significantly compromised level monocyte chemoattractant protein-1 (MCP-1) inflammatory protein (MIP-1α) relative gene expression, anti-CD31, anti-Mac-3,...
Introduction: This study aims to explore the reno-protective effect of Curcumin in focal and segmental glomerulosclerosis (FSGS) Murine models, a common chronic glomerulopathy that leads end stage renal disease. Methods: Adult Wistar rats were used this experiment. One group was treated with intravenous Adriamycin (ADR) injection induce FSGS similar seen humans second co-administered ADR (ADR-CUR). Saline served as controls. Renal injury assessed by measuring levels serum creatinine, blood...
We describe a 10-year-old boy with rare large multicystic pulmonary chondroid hamartoma in the right lower lobe presenting severe respiratory distress. The radiological evaluation showed lesion pneumothorax. Commonly, hamartomas are asymptomatic, small size, and diagnosed incidentally adults. Our case is highly unusual due to its young age, prominent clinical symptoms of distress pneumothorax at presentation, very cystic change. was surgically excised, histopathological features were...
Abstract Background The mechanisms underlying the association between obesity and coronavirus disease 2019 (COVID-19) severity remain unclear. After verifying that was a correlate of severe COVID-19 in US Military Health System (MHS) beneficiaries, we compared immunological virological phenotypes acute respiratory syndrome 2 (SARS-CoV-2) infection both obese nonobese participants. Methods COVID-19–infected MHS beneficiaries were enrolled, anthropometric, clinical, demographic data collected....
The prognostic impact of neoadjuvant chemotherapy (NAC) on the receptor expression status in patients with locally advanced breast cancer (LABC) is still not fully understood. We aimed to evaluate changes hormone (estrogen and progesterone) (HR) human epidermal growth factor 2 (HER2) post-NAC their correlation survival.Patients LABC who have received NAC between 2008 2015 been followed up till December 2019 at Oncology Center, King Saud University, KSA were analyzed retrospectively....
<h3>Objectives:</h3> To assess and age stratify the types frequencies of endometrial pathologies in Saudi women with abnormal uterine bleeding (AUB) that underwent biopsies, at our hospital over a 13-year period. <h3>Methods:</h3> In retrospective study, from 2006 to 2018, all biopsies AUB, reported laboratory King Saud University-Medical City, Riyadh, Arabia, were revisited analyzed. The categorized into <40, between 40-55 >55 years age. <h3>Results:</h3> We analyzed 6458 biopsies....
Recent international reports have shown significant changes in the incidence of different glomerular diseases.Examine temporal and demographic trends biopsy-diagnosed diseases adult population Saudi Arabia over last two decades.Medical record review.Four tertiary medical centers Arabia.We identified all patients that underwent native kidney biopsy between 1998 2017.The frequency disease four eras (1998-2002, 2003-2007, 2008-2011, 2012-2017) for diseases.1070 patients, 18-65 years age; 54.1%...
BACKGROUND Progranulin is an adipokine, encoded by the progranulin (GRN) gene. expressed in atherosclerosis, but its effects cardiac ischemia and reperfusion injury are unknown. Therefore, this study aimed to investigate of a rat model acute myocardial ischemia/reperfusion (MI/R) vivo. MATERIAL AND METHODS The MI/R was established male Wistar rats ligation left anterior descending (LAD) coronary artery for 30 minutes 60 minutes. Before modeling, one group treated with (0.03 µg/kg), P13K/Akt...
Aim: Focal segmental glomerulosclerosis (FSGS) is a common progressive chronic renal disease. Podocyte injury and loss are the postulated pivotal events that trigger FSGS. In this study, authors aim to examine evolution of FSGS in murine models histologically, ultrastructurally immunohistochemically with special emphasis on podocytes parietal epithelial cells (PECs). Material methods: resembling primary humans was initiated Wistar rats using intravenous Adriamycin injections. Blood urine...
<h3>Objectives:</h3> To examined the short and long-term outcome of class II lupus nephritis (LN). <h3>Methods:</h3> This retrospective study included patients with LN at their first renal biopsy between January 1996 December 2016 in King Khaled University Hospital, Riyadh, Saudi Arabia. The rate complete remission, worsening function, histological transformation second were examined. <h3>Results:</h3> 32 female LN. most frequent presentation (62.5% patients) was hematuria subnephrotic range...
Primary focal segmental glomerulosclerosis (FSGS) is a type of chronic renal disease that commonly progresses to failure as the treatments are not particularly effective. Glomerular podocyte injury and loss pivotal pathogenesis FSGS. This study aims explore glomerular immunohistochemistry stain expression Wilms tumor-1 (WT-1) (podocyte-specific protein), transforming growth factor beta (TGF-β) (cytokine vascular endothelial (VEGF) (angiogenic endothelin-1 (ET-1) (profibrotic factor), in rats...