Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) principal curcuminoid of turmeric possesses strong antioxidant anti-inflammatory activities. This study explored protective effect CUR Pb hepatotoxicity an emphasis oxidative stress, inflammation Akt/GSK-3β signaling. Rats received lead acetate and/or ascorbic acid (AA) for seven days samples were collected analyses. Pb(II) induced injury manifested by elevated serum alanine...

Doxorubicin (DOX) is a cytotoxic anthracycline antibiotic and one of the important chemotherapeutic agents for different types cancers. DOX treatment associated with adverse effects, particularly cardiac dysfunction. This study examined cardioprotective effects carvedilol (CAR) and/or resveratrol (RES) liposomal RES (LIPO-RES) against DOX-induced cardiomyopathy, pointing to their modulatory effect on oxidative stress, inflammation, S100A1 sarco/endoplasmic reticulum calcium ATPase2a...

Copper (Cu) is essential for multiple biochemical processes, and copper sulphate (CuSO4) a pesticide used repelling pests. Accidental or intentional intoxication can induce multiorgan toxicity could be fatal. Curcumin (CUR) potent antioxidant, but its poor systemic bioavailability the main drawback in therapeutic uses. This study investigated protective effect of CUR N-CUR on CuSO4-induced cerebral oxidative stress, inflammation, apoptosis rats, pointing to possible involvement Akt/GSK-3β....

Copper (Cu) is essential for a plethora of biological processes; however, its high redox reactivity renders it potentially toxic. This study investigated the protective effect curcumin (CUR) and nano-CUR (N-CUR) against Cu cardiotoxicity, emphasizing role oxidative stress, TLR4/NF-κB mitogen-activated protein kinase (MAPK) signaling cell death in rats. Rats received 100 mg/kg copper sulfate (CuSO4), pesticide used repelling pests, were concurrently treated with CUR or N-CUR 7 days. caused...

The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin their combination in regulation immuno-inflammatory mediators heat shock protein expressions sodium nitrite induced hypoxia rat lungs. results revealed that NaNO2 injection caused a significant decrease Hb rats, while serum levels TNF-α, IL-6 CRP, VEGF HSP70 were elevated compared control group. Administration melatonin, quercetin or before markedly reduced these parameters....

Calotropis procera is traditionally used for treating many diseases including ulcers and tumors. It was thus deemed of interest to investigate compare the antiulcer cytotoxic activities C. leaf, flower, fruit extracts in an attempt verify its traditional uses. Phytochemical studies on fruits, flowers, leaves procera, collected from desert Saudi Arabia, led isolation one new lignan 7'-methoxy-3'-O-demethyl-tanegool-9-O-β-d-glucopyranoside five known compounds four leaves, a flavonoid...

Abstract The objective of this work is to study the protective effects Quercetin against sodium nitrite‐induced hypoxia on liver, lung, kidney and cardiac tissues, also explore novel mechanism compound. Male albino rats were injected with nitrite (75 mg/kg). (200 mg kg −1 ,‐ i.p.) was administrated 24 1 h respectively prior intoxication, significantly decreased hemoglobin concentration, while increased expressions HIF, Bax, Smad‐2, TGF‐β, AKT. However, administration played a modulatory role...

Copper is essential for several cellular processes and an important catalytic factor many proteins. However, excess copper can provoke oxidative stress reproductive toxicity. This study evaluated the effect of liposomal nano-curcumin (N-CUR) CUR on testicular injury, inflammation, apoptosis, altered steroidogenesis Nrf2/HO-1 signaling induced by sulfate (CuSO4). Rats received CuSO4 N-CUR or via oral gavage 7 days. histopathological changes pituitary-gonadal axis manifested decreased serum...

Transforming growth factor-β (TGF-β1) enhances the expression of apoptosis induced by certain cytokines and oncogenes. Activation small mother against decapentaplegic (Smads) TGF-β results in fibrotic, apoptotic processes. PI-3/AKT focal adhesion kinase-phosphatidylinositol3-kinase (AKT), mitogen-activated protein kinase (MAPK) signal transducer activator transcription-3 (STAT3) pathways are influence COX-2 VEGF-stimulating pathways. NF-E2-related factor-2 (Nrf2) is an essential...

Arctium lappa L. (A. lappa) is a popular medicinal plant with promising hepatoprotective activity. This study investigated the protective effect of A. root extract (ALRE) on lead (Pb) hepatotoxicity, pointing to its ability modulate oxidative stress, inflammation, and protein kinase B/Akt/glycogen synthase (GSK)-3β signaling. Rats received 50 mg/kg acetate (Pb(Ac)2) 200 ALRE or vitamin C (Vit. C) for 7 days, blood liver samples were collected. Pb(Ac)2 provoked hepatotoxicity manifested by...

The underlying pathology of cardiac damage involves various molecular and signaling pathways. Therefore, this study aimed to explore the role Quercetin (Querc), alone or in combination with Melatonin (Melat) against induced by sodium nitrite (Sod nit), as well elucidate different Querc Melat were injected intraperitoneally (i.p.), followed induction hypoxia rats using a single dose Sod nit (60 mg/kg, s.c.). Treatment significantly decreased hemoglobin (Hb) levels blood. Pretreatment hypoxic...

This study is designed to evaluate the potential impact of N-acetyl cysteine (NAC) and coenzyme Q10 (CoQ10) each alone or in combination against carbon tetrachloride (CCl4)-induced cardiac damage rats. Animals were treated with CCl4 single intraperitoneal dose 1 mL/Kg body weight; CCl4-intoxicated animals pretreated 20 mg/kg/d NAC 200 CoQ10 same previously mentioned doses. Carbon tetrachloride-intoxicated rats showed a significant elevation nitric oxide lipid peroxides downregulation reduced...

Abstract The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose‐dependent cardiotoxicity. aim this study was to evaluate cardioprotective effect combination carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR‐induced cardiomyopathy in rats. results present showed that DOXR administration significantly increased heart weight/body weight ratio 35.6%, creatine kinase‐MB (CK‐MB) 40.6%, troponin‐I levels 85%, decreased reduced glutathione level superoxide...

Abstract The aim of this study was to compare the potential renoprotective effects turmeric (TM) and nano (NTM) with those desferrioxamine (DSM) against copper sulfate (CS)‐induced toxicity. Rats were administered a toxic dose CS TM, NTM, DSM for 1 week. Next, serum‐urea creatinine, uric acid, interleukin (IL)‐10, c‐reactive protein (CRP), caspase‐3 levels; renal nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), vascular cell adhesion molecule‐1...

This study aimed to explore the effective role of carnosine and /or L- arginine in down regulation inflammatory molecule expression caused renal damage response sodium nitrite (NaNO2) induced hypoxia rats . NaNO2 was administered subcutaneously (s.c.) as a single dose (60 mg/kg body weight ). L-arginine (200mg/Kg weight) (250 mg/ Kg ) were (i.p.) , 24 h before injection. The results revealed that pre- administration hypoxic rats, significantly modulated increases serum markers function...

Doxorubicin (DOXR) belongs to the antineoplastic anthracycline antibiotic and despite its prevalent use for various types of cancer, it is associated with side effects that occur even after treatment cessation, particularly on heart, blood, liver kidney. This study aimed efficiency carvedilol (CAR), resveratrol (RES) or liposomal RES (LIPO-RES) their combination treat DOXR-induced hepatotoxicity investigate other driving mechanisms are involved. Rats were injected twice weekly DOXR five...

Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced damage until now. Aim: This work aims at examining potential impact nano-resveratrol (N-Resv), native resveratrol (Resv), and their combination with carvedilol (Card) against toxicity in rats to investigate mechanisms through which these antioxidants act ameliorate DXR nephrotoxicity. Method: was administered (2...

Acetaminophen (APAP)-induced nephrotoxicity is detrimental consequence for which there has not been a standardized therapeutic regimen. Although, N-acetylcysteine (NAC) well-known antidote used in APAP-induced hepatotoxicity, its benefit caused by APAP almost lacking. This study aimed to compare the possible protective effect of thymoquinone (TQ), curcumin (CR), and α-lipoic acid (α-LA), either solo or combination regimens with that NAC against renal injury.Rats were divided into nine...

The objective of this study is to examine whether silymarin alone or in combination with chlorogenic acid and/ melatonin plays a modulatory role against apoptotic damage rats liver induced by CCl4. present work revealed that CCl4 elevation Bax, Smad, TGF-β and NFkBhepatic mRNA expression, administration down regulates these expressions. Treatment along produced best results concern. Bcl-2 expression was regulated whereas concurrent treatment increased expression. On conclusion, the use...