A5040460731- Chemotherapy-induced cardiotoxicity and mitigation
- Chemotherapy-induced organ toxicity mitigation
- Curcumin's Biomedical Applications
- Parkinson's Disease Mechanisms and Treatments
- Heavy Metal Exposure and Toxicity
- Carbon Nanotubes in Composites
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Zoonotic diseases and public health
- Cancer-related cognitive impairment studies
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Asthma and respiratory diseases
- Medicinal Plants and Neuroprotection
- Patient Satisfaction in Healthcare
- Attention Deficit Hyperactivity Disorder
- Antibiotic Use and Resistance
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- Iron Metabolism and Disorders
- Cancer Treatment and Pharmacology
- Artificial Intelligence in Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
Ministry of Health
2024
King Saud University
2019-2023
King Fahad Specialist Hospital
2021-2023
King Fahd Medical City
2022-2023
Almaarefa University
2022
Doxorubicin (DOX) is a cytotoxic anthracycline antibiotic and one of the important chemotherapeutic agents for different types cancers. DOX treatment associated with adverse effects, particularly cardiac dysfunction. This study examined cardioprotective effects carvedilol (CAR) and/or resveratrol (RES) liposomal RES (LIPO-RES) against DOX-induced cardiomyopathy, pointing to their modulatory effect on oxidative stress, inflammation, S100A1 sarco/endoplasmic reticulum calcium ATPase2a...
Lead is a common environmental and occupational pollutant which induced multiorgans dysfunction. The present study was designed to investigate the hepatoprotective effects of turmeric (TUR) and/or vitamin C (Vit-C) alone or together against lead acetate toxicity explore novel molecular pathways.Acute hepatotoxicity by (100 mg/kg/day, i.p.) in male rats, effect TUR (200 orally) Vit-C (250 along with for 7 days studied.Lead increased serum alanine transaminase, aspartate lactate dehydrogenase,...
Abstract The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose‐dependent cardiotoxicity. aim this study was to evaluate cardioprotective effect combination carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR‐induced cardiomyopathy in rats. results present showed that DOXR administration significantly increased heart weight/body weight ratio 35.6%, creatine kinase‐MB (CK‐MB) 40.6%, troponin‐I levels 85%, decreased reduced glutathione level superoxide...
Background and Objectives The mental physical functioning of an individual is partly determined by their health-related quality life (HRQOL), which a multifaceted component. Women who have recently given birth must good to provide proper care development for infant. purpose this study was assess the relationship between postpartum depression (PPD) HRQOL in Saudi Arabian women identify potential risk factors that could influence them. Methods This comprised 253 mothers aged 1–24 weeks from...
Doxorubicin (DOXR) belongs to the antineoplastic anthracycline antibiotic and despite its prevalent use for various types of cancer, it is associated with side effects that occur even after treatment cessation, particularly on heart, blood, liver kidney. This study aimed efficiency carvedilol (CAR), resveratrol (RES) or liposomal RES (LIPO-RES) their combination treat DOXR-induced hepatotoxicity investigate other driving mechanisms are involved. Rats were injected twice weekly DOXR five...
Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced damage until now. Aim: This work aims at examining potential impact nano-resveratrol (N-Resv), native resveratrol (Resv), and their combination with carvedilol (Card) against toxicity in rats to investigate mechanisms through which these antioxidants act ameliorate DXR nephrotoxicity. Method: was administered (2...
Propionic acid (PRA) is a metabolic end-product of enteric bacteria in the gut, and it commonly used as food preservative. Despite necessity PRA for immunity body, excessive exposure to this product may result disruptive effects. The purpose study examine hepatoprotective effects acetyl-L-carnitine (A-CAR) liposomal-coenzyme Q10 (L-CoQ10) against PRA-induced injury. Liver injury rats was induced by oral administration PRA, A-CAR L-CoQ10 were administered concurrently with 5 days. Oxidative...
Mercury is the third most hazardous heavy metal and its toxicity causes a severe health risk through unfavorable detrimental pathological biochemical effects. widely found in many ecological certain occupational settings. The aim of this study to elucidate neuroprotective role vitamin E (VE) Lactobacillus plantarum (LTB) either alone or combination against toxic sublethal dose Mercuric chloride (MC). First group served as normal control group; rats from second were intoxicated with (5 mg/kg...
Background: Atopic dermatitis (AD) is one of the most prevalent chronic conditions in children. It a global public health concern because its burden on systems. The disease usually associated with comorbidities including psychosocial and behavioural problems. Objectives: To explore emotional symptoms peer relationship problems, hyperactivity/inattention, prosocial behaviour among Saudi children atopic Methods: A cross-sectional study was conducted during November 2022 through an onlinesurvey...
Precision medicine is the new frontier in health management since it involves development of at molecular level individual patient by considering his/her genomic, environmental, and lifestyle characteristics. The special contribution these scientific achievements to reality current future healthcare delivery systems cannot be overemphasized; better said, scrip-swinging part played workers worldwide actualizing discoveries need not overemphasized. This comprehensive review explores multiple...
Autophagy and apoptosis are two important regulatory mechanisms for how the body can respond to diseases. This study was designed investigate protective actions of vitamin E (Vit-E) lactobacillus plantarum (Lac-B) against mercuric chloride (HgCl2)-induced kidney injury. Thirty albino rats were divided into five groups: group 1 served as normal group; in 2 received high doses HgCl2; groups 3, 4 5 given Vit-E, Lac-B combination Vit-E Lac-B, respectively along with HgCl2 weeks. provoked renal...
Background: Herbal remedies are agents that known to hasten the healing process of a variety wounds where plant products efficacy in wound was confirmed.Some most important plants and herbal Aloe Vera, sesame oil shea butter.Thus, this study aimed prepare ointments creams contain natural extracts 2023 Dec.