A5101501277- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diagnosis and treatment of tuberculosis
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Amoebic Infections and Treatments
- Neuropeptides and Animal Physiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Colorectal Cancer Screening and Detection
- Lipid metabolism and disorders
- Pregnancy and preeclampsia studies
- Urological Disorders and Treatments
- Adipose Tissue and Metabolism
- Infectious Diseases and Tuberculosis
The University of Texas at Arlington
2024
Pennsylvania State University
2023
National Institute of Diabetes and Digestive and Kidney Diseases
2019-2022
National Institutes of Health
2019-2022
Alfred Health
2020-2021
University of California, San Diego
2018
Sanford Consortium for Regenerative Medicine
2018
Massachusetts General Hospital
2017
Harvard University
2017
University of California, Irvine
2012
Glucagon, a hormone released from pancreatic α cells, plays key role in maintaining proper glucose homeostasis and has been implicated the pathophysiology of diabetes. In vitro studies suggest that intraislet glucagon can modulate function β cells. However, because lack suitable experimental tools, vivo physiological this cross-talk remained elusive. To address issue, we generated mouse model selectively expressed an inhibitory designer GPCR (Gi DREADD) cells only. Drug-induced activation...
Abstract Aim Thrombospondins are a family of multidomain and secretory glycoproteins. Among them, thrombospondin 2 (TSP2) encoded by TSP2 gene has been reported to be involved in various functions such as collagen/fibrin formation, maintenance normal blood vessel density cell adhesion properties. Microarray analyses ranked one the most highly up‐regulated genes fibrotic liver patients with non‐alcoholic fatty disease (NAFLD). Since possesses unique properties protein, we hypothesized that...
The incidence of Alzheimer's disease increases in people who have had an ischemic episode. Furthermore, APP expression is increased following or hypoxic conditions, as the production Aβ peptide. To address question why and are conditions we induced episode knockout mice (APP-/-) BACE1 (BACE-/-). We find that both APP-/- BACE-/- a dramatically risk mortality result cerebral ischemia. reduced blood flow response to hypoxia, while wild-type maintain increase same conditions. transcription...
Significance Type 2 diabetes (T2D) has emerged as a major threat to human health worldwide. In T2D, pancreatic β cells are unable release sufficient amounts of insulin maintain physiological blood glucose levels. Acetylcholine (ACh) stimulates from mouse and by activating cell surface receptor known M 3 muscarinic ACh (M3R). the present study, we show that drug binds an allosteric site on M3R (a distinct ACh-binding site) greatly enhances ACh-induced, M3R-mediated improves homeostasis in...
Benign prostatic hyperplasia is the most common proliferative abnormality of prostate. All men experience some growth as they age, but rate varies among individuals. Steroid 5α-reductase 2 (SRD5A2) a critical enzyme for development and growth. Previous work indicates that one-third adult samples do not express SRD5A2, secondary to epigenetic modifications. Here we show level oestradiol dramatically elevated, concomitant with significant upregulation oestrogen response genes, in methylation...
β-Arrestin-1 and β-arrestin-2 have emerged as important signaling molecules that modulate glucose fluxes in several peripheral tissues. The potential roles of neuronally expressed β-arrestins regulating homeostasis remain unknown. We here report mice lacking β-arrestin-1 (barr1) selectively AgRP neurons displayed impaired tolerance insulin sensitivity when consuming an obesogenic diet, while overexpressing barr1 were protected against obesity-associated metabolic impairments. Additional...
Accurate detection of the hepatic fibrosis stage is essential to estimate outcome patients with non-alcoholic fatty liver disease (NAFLD). Many formulas, biomarkers, and imaging tests are being developed predict advanced without performing a biopsy. However, these do not have high efficiency in detecting early-stage fibrosis. Therefore, we aimed detect presence (≥F1) merely by using only standard clinical markers.A total 436 NAFLD who underwent biopsy were retrospectively enrolled as...
The prognosis of nonalcoholic fatty liver disease is determined by biopsy; steatohepatitis can be progressive whereas benign. Insulin resistance and increased hepatic-free acids are central to the pathophysiology this disorder. Our objective was assess whether serum-free acids, lipoproteins, insulin in compared with healthy controls, thus may potential noninvasive markers for severity.Fifteen subjects biopsy proven steatohepatitis, 15 histological liver, controls were enrolled. Fasting serum...
Heavy alcohol drinking habits contribute to the development of hypertension; this is partly due overactivation sympathetic nervous system and increased release catecholamines. Recently, heavy has been linked poor sleep quality, but underlying mechanisms remain unclear. We postulated that long-term frequent use could increase catecholamine levels cause blood pressure dysregulation at night, altogether influencing quality. Therefore, purpose study test following hypothesis compared non-heavy...
Introduction: As our population ages, type 2 diabetes has become more prevalent in the United States and one five mid-life adults (50-64 years) have diabetes. Unhealthy heavy alcohol use (that exceeds recommended drinking limits) causes dysfunction of liver pancreas that can impact glucose control thereby increase risks In young adults, we previously found fasting insulin resistance were not associated with use. However, it remains unclear if contributes to development an aged population....
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology1 Apr 2017MP17-07 ANDROGENIC TO ESTROGENIC SWITCH IN PROSTATE GLAND AS A RESULT OF EPIGENETIC SILENCING STEROID 5-? REDUCTASE 2 Zongwei Wang, Libing Hu, Rongbin Ge, Keyan Salari, Seth Bechis, Shulin Wu, Cyrus Rassoulian, Jonathan Pham, Shahin Tabetabaei, Chin-Lee Douglas Strand, and Aria Olumi WangZongwei Wang , HuLibing Hu GeRongbin Ge SalariKeyan Salari BechisSeth Bechis WuShulin Wu...
Introduction: Although inlet patches are common, they typically asymptomatic and usually incidental findings. Rarely, strictures can occur as a result of patch acid production may lead to dysphagia. We present case an related esophageal stricture highlight disease diagnosis management. Case Description/Methods: A 76-year-old woman presented her primary care provider after 6 years intermittent, progressively worsening solid food dysphagia that would at least twice month, resulting in...
Aim: This study aims to examine trends in incidence and mortality of colorectal cancer (CRC) using a state-wide registry, focusing on race, age, rurality. Methods: From 1990 2019, CRC age-adjusted were examined through the Pennsylvania Cancer Registry Joinpoint Regression model average annual percent changes (AAPC). Results: In Pennsylvania, there was decline (AAPC -1.7) -2.5), consistent regardless race or stage, with an inflection 2000s demonstrating greater rate decrease. Conversely,...