A5004110157- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Organ Donation and Transplantation
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Healthcare Policy and Management
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Transplantation: Methods and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- HIV/AIDS drug development and treatment
- Economic and Financial Impacts of Cancer
- Gastroesophageal reflux and treatments
- COVID-19 and healthcare impacts
- Global Health Care Issues
University of Miami
2019-2025
Monterey Peninsula College
2024
Sylvester Comprehensive Cancer Center
2022-2024
University of Miami Health System
2022-2023
Icahn School of Medicine at Mount Sinai
2009-2022
Hospital of the University of Pennsylvania
2009-2021
Jackson Memorial Hospital
2020-2021
University of Pennsylvania
2011-2020
Kentucky Science Center
2020
Health Protection Scotland
2005-2020
The availability of direct-acting antiviral agents for the treatment hepatitis C virus (HCV) infection has resulted in a profound shift approach to management this infection. These changes have affected practice solid organ transplantation by altering framework which patients with end-stage disease are managed and receive transplants. high level safety efficacy these medications chronic HCV provides opportunity explore their use setting transplanting organs from HCV-viremic into...
Background: Organs from hepatitis C virus (HCV)–infected deceased donors are often discarded. Preliminary data 2 small trials, including THINKER-1 (Transplanting Hepatitis kidneys Into Negative KidnEy Recipients), suggested that HCV-infected could be safely transplanted into HCV-negative patients. However, intermediate-term on quality of life and renal function needed to counsel patients about risk. Objective: To describe 12-month HCV treatment outcomes, estimated glomerular filtration rate...
The term acute‐on‐chronic liver failure (ACLF) is intended to identify patients with chronic disease who develop rapid deterioration of function and high short‐term mortality after an acute insult. two prominent definitions (European Association for the Study Liver [EASL] Asian Pacific [APASL]) differ, existing literature applies narrow patient groups. We sought compare ACLF incidence among a diverse cohort compensated cirrhosis, using both definitions. This was retrospective study incident...
New antiviral therapies for hepatitis C virus infection, with cure rates exceeding 95%, should prompt transplant-community leaders to view HCV-positive organs as a valuable opportunity transplant candidates or without preexisting HCV infection.
Death rates from drug overdoses have nearly doubled since 2003, with over 47 000 deaths in 2014. This is largely attributable to the opioid epidemic. If unfortunate of otherwise healthy people yielded an increase organ donors, then this might serve as perhaps only comforting factor among tragic and unnecessary loss life. In viewpoint, we present data Organ Procurement Transplantation Network (OPTN) that show how greatest relative increases mechanism death deceased donors 2003 2014 were...
Centralization of specialized health care services such as organ transplantation and bariatric surgery is advocated to improve quality, increase efficiency, reduce cost. The effect increased travel on access outcomes from these not fully understood.To evaluate the association between distance a Veterans Affairs (VA) transplant center (VATC) being waitlisted for liver transplantation, actually having transplant, mortality.Retrospective study veterans meeting eligibility criteria January 1,...
Journal Article Social Justice, Health Inequalities and Methodological Individualism in US Promotion Get access Daniel S. Goldberg * East Carolina University, USA *Corresponding author: Goldberg, Department of Bioethics & Interdisciplinary Studies, Brody School Medicine, 600 Moye Blvd, Mailstop 641, Greenville, NC 27834, USA. Tel.: 252.744.5699; Fax: 252.744.2319; Email: goldbergd@ecu.edu Search for other works by this author on: Oxford Academic PubMed Google Scholar Public Ethics, Volume 5,...
PURPOSE: Use of administrative or population-based databases for post-marketing pharmacoepidemiology research in patients with end-stage liver disease (ESLD) has been limited by the difficulty accurately identifying such patients. Algorithms to identify ESLD using ICD-9-CM codes have not developed outside Veterans Affairs healthcare setting. METHODS: We queried electronic medical records at two tertiary care hospitals indicative ESLD. Coding algorithms were confirmed ESLD, and these tested...
Candidates with hepatocellular carcinoma (HCC) within the Milan criteria (MC) receive standardized Model for End-Stage LIver Disease (MELD) exception points because of projected risk tumor expansion beyond MC. Exception at listing are meant to be equivalent a 15% rusj if 90-day mortality, additional granted every 3 months, 10% increased morality risk. We analyzed United Network Organ Sharing database (January 1, 2005 May 31, 2009) compare waitlist outcomes HCC candidates and non-HCC similar...
Patients with cirrhosis are at increased risk of postoperative mortality. Currently available tools to predict suboptimally calibrated and do not account for surgery type. Our objective was use population-level data derive internally validate surgical models.
Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality in cirrhosis patients. This provides an opportunity to target the highest-risk population, yet surveillance rates United States Europe range from 10% 40%. The goal this study was identify barriers HCC surveillance, using data Veterans Health Administration, largest provider liver-related health care States. We included all patients 75 years age or younger who were diagnosed with January 1, 2008, until December 31,...
The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated tremendous interest in transplanting organs from HCV-infected donors. We conducted a single-arm trial orthotopic heart transplantation (OHT) donors into uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first detected (NCT03146741; sponsor: Merck). enrolled OHT candidates aged 40-65 years; left ventricular assist device (LVAD) support and liver disease were...
Objectives: We sought to assess consent rates for organ donation from potential brain-dead donors, and identify factors associated with variation in that could guide the development of targeted interventions increase rates. Design, Setting, Subjects: used data provided by Organ Procurement Transplantation Network analyze 35,823 procurement organization–reported eligible deaths (potential donors ≤ 70 yr age) January 1, 2008, October 31, 2011. Measurements Main Results: Excluding cases where...
Guidelines recommend restricting simultaneous liver-kidney (SLK) transplant to candidates with prolonged dialysis or estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m(2) for 90 days. However, few studies exist support the latter recommendation. Using Scientific Registry of Transplant Recipients and Medicare data, we assembled a cohort 4997 liver recipients from February 27, 2002-January 1, 2008. Serial eGFRs were calculated serum creatinines submitted MELD reports. We categorized...