A5044306241- Diabetes and associated disorders
- Diabetes Management and Research
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Rheumatoid Arthritis Research and Therapies
- Advanced Optimization Algorithms Research
- Risk and Portfolio Optimization
- Metabolomics and Mass Spectrometry Studies
- Venomous Animal Envenomation and Studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Statistical Methods and Inference
- Bioinformatics and Genomic Networks
- Plant Reproductive Biology
- Cardiovascular Function and Risk Factors
- melanin and skin pigmentation
- Spider Taxonomy and Behavior Studies
- Chronic Kidney Disease and Diabetes
- Chronic Lymphocytic Leukemia Research
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
Leipzig University
2023
University of Edinburgh
2010-2022
University Hospital Leipzig
2022
Ospedale di Circolo di Busto Arsizio
2009-2022
Institute of Genetics and Cancer
2020
Glasgow Centre for Population Health
2017-2018
University of Cambridge
2018
NHS Fife
2015
Maxwell Institute for Mathematical Sciences
2013
University of Pisa
2013
Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans renal function diabetes.Using serum samples from 818 adults who were considered to have extreme annual loss estimated glomerular filtration rate (eGFR; i.e., slope) based retrospective clinical records, among 6,127 the Scottish Diabetes Research Network Type Bioresource...
Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence ~50% by age 50; however, known genes explain little heritability. Here, we present results genome-wide association study including more than 70,000 identifying 71 independently replicated loci, which 30 are novel. These loci 38% risk, suggesting that MPB less genetically complex other traits. We show many these contain relevant to pathology and highlight pathways...
The objective of this cross-sectional study was to explore the relationship detectable C-peptide secretion in type 1 diabetes clinical features and genetic architecture diabetes. measured an untimed serum sample SDRNT1BIO cohort 6076 Scottish people with clinically diagnosed or latent autoimmune adulthood. Risk scores at loci previously associated 2 were calculated from publicly available summary statistics. Prevalence varied 19% those onset before age 15 duration greater than years 92%...
As part of the Surrogate Markers for Micro- and Macrovascular Hard Endpoints Innovative Diabetes Tools (SUMMIT) programme we previously reported that large panels biomarkers derived from three analytical platforms maximised prediction progression renal decline in type 2 diabetes. Here, hypothesised smaller (n ≤ 5), platform-specific combinations selected these larger might achieve similar performance when tested additional diabetes cohorts.We used 657 serum samples, held under differing...
Abstract Prospective biomarker studies can be used to identify biomarkers predictive of disease onset. However, if serum are measured years after their collection, the storage conditions might affect analyte concentrations. Few data exists concerning which metabolites and proteins affected by at − 20 °C vs 80 °C. Our objectives were document analytes samples °C, those indicative temperature. We utilized liquid chromatography tandem mass spectrometry Luminex quantify 300 from 16 Finnish...
We aimed to identify a sparse panel of biomarkers for improving the prediction renal disease progression in type 1 diabetes.We considered 859 individuals recruited from Scottish Diabetes Research Network Type Bioresource (SDRNT1BIO) and 315 Finnish Diabetic Nephropathy (FinnDiane) study. All had an entry eGFR between 30 75 ml min-1[1.73 m]-2, with those FinnDiane being oversampled albuminuria. A total 297 circulating (30 proteins, 121 metabolites, 146 tryptic peptides) were measured...
Imaging of joint inflammation provides a standard against which to derive an updated DAS for RA. Our objectives were develop and validate based on reweighting the DAS28 components maximize association with US-assessed synovitis.
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From population-representative Scottish Diabetes Research Network Type Bioresource (SDRNT1BIO) we sampled 50% and 25% those starting eGFR below above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), median 5.1 years follow-up....
We aimed to report current rates of CVD in type 1 diabetes and develop a risk prediction tool for diabetes.A cohort 27,527 people with without prior was derived from the national register Scotland. Incident events during 199,552 person-years follow-up were ascertained using hospital admissions death registers. A Poisson regression model developed then validated Swedish National Diabetes Register (n = 33,183). compared percentage high 10 year (i.e., ≥10%) eligible statins guidelines by...
Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment has been revolutionised tumour necrosis factor alpha inhibitors (TNFi) but each available drug shows a significant non-response rate. We conducted genome-wide association study of 1752 UK RA TNFi-treated patients to identify predictors change in the Disease Activity Score 28 (DAS28) and subcomponents over 3–6 months. The rs7195994 variant at FTO gene locus was associated with infliximab response when...
Abstract We address the task of genotype imputation to a dense reference panel given likelihoods computed from ultralow coverage sequencing as inputs. In this setting, data have high-level missingness or uncertainty, and are thus more amenable probabilistic representation. Most existing algorithms not well suited for situation, they rely on prephasing computational efficiency, and, without definite calls, becomes computationally expensive. describe GeneImp, program that does require is...
Fasting indices of glucose-insulin-metabolism are an easy and affordable tool to assess insulin resistance. We aimed establish reference ranges for fasting that reflect age-dependent variation over the entire life span subsequently test their clinical application regarding prediction glycemic deterioration in children. calculated age- puberty-dependent values HOMA-IR, HOMA2-IR, HOMA-β, McAuley index, insulin, glucose from 6994 observations 5512 non-obese healthy subjects aged 5–80 years....
Abstract Aims/hypothesis The aim of this study was to provide data from a contemporary population-representative cohort on rates and predictors renal decline in type 1 diabetes. Methods We used 5777 people with diabetes aged 16 older, diagnosed before the age 50, representative adult population Scotland (Scottish Diabetes Research Network Type Bioresource; SDRNT1BIO). measured serum creatinine urinary albumin/creatinine ratio (ACR) at recruitment linked national electronic healthcare...
We sought to investigate whether genetic effects on response TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known susceptibility loci for relevant traits and evaluate the usefulness of these stratifying drug response.We studied relation TNFi response, quantified change swollen joint counts ( Δ SJC) erythrocyte sedimentation rate ESR) with locus-specific scores constructed from genome-wide assocation study summary statistics 2938 genotyped individuals: 37...
Suboptimal nutrition in pregnancy is associated with worse offspring cardiometabolic health. DNA methylation may be an underlying mechanism. We meta-analyzed epigenome-wide association studies (EWAS) of maternal dietary glycemic index and load cord blood methylation.We calculated from food frequency questionnaires ran EWAS on 2,003 mother-offspring pairs three cohorts. Analyses were additionally stratified by BMI categories. looked-up the findings traits as well birth weight child BMI....
An assessment of the population dynamics Microtityus jaumei Armas (Scorpiones: Buthidae) on slopes south Sierra de Canasta, Guantánamo Province, Cuba show an increase in activity over year (≤ 0.05). The peak is related to reproductive period from June November. abundance scorpions was significantly density canopy and thickness substrate.