A5011732617- Mesenchymal stem cell research
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Parkinson's Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Multiple Sclerosis Research Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Dermatologic Treatments and Research
- Metabolomics and Mass Spectrometry Studies
- Osteoarthritis Treatment and Mechanisms
- BRCA gene mutations in cancer
- Genomic variations and chromosomal abnormalities
- Reproductive Physiology in Livestock
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
- Extracellular vesicles in disease
Michigan State University
2024-2025
Henry Ford Health System
2016-2025
Michigan United
2014-2025
National Institute of Mental Health and Neurosciences
2016-2024
Henry Ford Hospital
2010-2024
Henry Ford Health + Michigan State University Health Sciences
2024
Rutgers, The State University of New Jersey
2023
Florida State University
2023
Tata Memorial Hospital
2020
Université de Sherbrooke
2020
Sarcoidosis is a systemic inflammatory disease characterized by the formation of granulomas in affected organs. Genome-wide association studies (GWASs) this have been conducted only European population. We present first sarcoidosis GWAS African Americans (AAs, 818 cases and 1,088 related controls) followed replication independent sets AAs (455 557 (EAs, 442 2,284 controls). evaluated >6 million SNPs either genotyped using Illumina Omni1-Quad array or imputed from 1000 Genomes Project data....
Metabolic aberrations impact the pathogenesis of multiple sclerosis (MS) and possibly can provide clues for new treatment strategies. Using untargeted metabolomics, we measured serum metabolites from 35 patients with relapsing-remitting (RRMS) 14 healthy age-matched controls. Of 632 known detected, 60 were significantly altered in RRMS. Bioinformatics analysis identified an metabotype RRMS, represented by four changed metabolic pathways glycerophospholipid, citrate cycle, sphingolipid,...
Despite advances in novel therapeutic approaches for the treatment of glioblastoma (GBM), median survival 12-14 months has not changed significantly. Therefore, there is an imperative need to identify molecular mechanisms that play a role patient survival. Here, we analyzed expression and functions lncRNA, TALNEC2 was identified using RNA seq E2F1-regulated lncRNAs. localized cytosol its cell-cycle dependent. highly expressed GBM with poor prognosis, specimens derived from short-term...
Acquisition of metabolic alterations has been shown to be essential for the unremitting growth cancer, yet relation such chemosensitivity not investigated. In present study our aim was identify that are specifically associated with platinum resistance in ovarian cancer. A global analysis A2780 platinum-sensitive and its platinum-resistant derivative C200 cancer cell line performed utilizing ultra-high performance liquid chromatography/mass spectroscopy gas spectroscopy. Per-metabolite...
Abstract Dental pulp originating from the neural crest is considered a better source of postnatal stem cells for cell‐based therapies in neurodegenerative diseases. Pulp Stem Cells (DPSCs) have been shown to differentiate into cell‐types cranial ontology; however, their ability functional neurons central nervous system remains be studied. We hypothesized that midbrain cues might commit DPSCs dopaminergic cell‐type. As expected, naïve state spontaneously expressed early and mature neuronal...
HLA-DRB1 is a sarcoidosis risk gene, and the *03:01 allele strongly associated with disease resolution in European cases. Whereas variation susceptibility African Americans, DRB1 alleles are not as well defined, associations have been studied. Associations between genotyped imputed susceptibility/resolution were evaluated sample of 1,277 African-American patients 1,467 control subjects. In silico binding assays performed to assess functional significance alleles. Increased was *12:01 (odds...
Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 in the thymus. However, underlying molecular programs that guide iNKT subset remain unclear. Here, we profiled transcriptomes of over 17,000 and chromatin accessibility states 39,000 across four thymic developmental stages using single-cell RNA sequencing (scRNA-seq) assay for transposase-accessible (scATAC-seq) define trajectories. Our study discovered...
Based on early occurrence in chronological age, stem‐cells from human exfoliated deciduous teeth (SHED) has been reported to possess better differentiation‐potential toward certain cell‐lineage comparison adult (DPSCs). Whether this same property between them extends for the yield of functional central nervous system neurons is still not evaluated. Hence, we aim assess neuronal plasticity SHED DPSCs dopaminergic‐neurons and further, if difference reflected a differential expression...
Triple negative breast cancers (TNBCs) are molecularly heterogeneous, and the link between their aggressiveness with African ancestry is not established. We investigated primary TNBCs for gene expression among self-reported race (SRR) groups of American (AA,
Va24-invariant human natural killer T (NKT) cells comprise a unique subset of CD1d-restricted with potent immune regulatory function and are involved in the development variety diseases. However, lack comprehensive molecular identities limits their objective classification clinical application. Using unbiased single-cell RNA sequencing (scRNA-seq) over 4000 unstimulated 7000 stimulated peripheral blood NKT cells, we identified four five clusters from each group, respectively. Our study...
Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates because an incomplete understanding biological mechanisms that lead to keloids. The purpose this project was examine keloid pathogenesis from epigenome perspective DNA methylation. Genome-wide profiling used Infinium HumanMethylation450 BeadChip interrogate 6 fresh and normal samples 12 anonymous donors. A...
ABSTRACT Post mortem studies on familial and sporadic Parkinson's disease patient striatal tissue have shown that nearly 90% of α‐synuclein deposited in Lewy‐bodies is phosphorylated at serine‐129 (pSyn‐129) as opposed to only 4% normal human brain. We aimed find the influence endogenous neurotoxin 6‐hydroxydopamine (6‐OHDA) phosphorylation, resting vesicles, vesicular dopamine release. The relative distribution pSyn‐129+ cells apoptotic non‐apoptotic populations different 6‐OHDA...
Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) the DNA-alkylating agent temozolomide (TMZ). In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, DNA methylation profiling, to investigate response of a representative panel GBM patient-derived cancer stem cells...
Sarcoidosis is a complex, multi-organ granulomatous disease with likely genetic component. West African ancestry confers higher risk for sarcoidosis than European ancestry. Admixture mapping provides the most direct method to locate genes that underlie such ethnic variation in risk. We sought identify variants within four previously-identified ancestry-associated regions—6p24.3–p12.1, 17p13.3–13.1, 2p13.3–q12.1, and 6q23.3–q25.2—in sample of 2,727 Americans. used logistic regression fit by...
Elevated blood pressure (BP) and renal dysfunction are complex traits representing major global health problems. Single nucleotide polymorphisms identified by genome-wide association studies have the Alström syndrome 1 (ALMS1) gene locus to render susceptibility for dysfunction, hypertension, chronic kidney disease (CKD). Mutations in ALMS1 humans causes syndrome, characterized progressive metabolic alterations including hypertension CKD. Despite compelling genetic evidence, underlying...