A5010185965- Dermatologic Treatments and Research
- Reconstructive Facial Surgery Techniques
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Facial Rejuvenation and Surgery Techniques
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Wound Healing and Treatments
- Nasal Surgery and Airway Studies
- Hair Growth and Disorders
- Renal and Vascular Pathologies
- Ureteral procedures and complications
- Vascular anomalies and interventions
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Body Contouring and Surgery
- Head and Neck Anomalies
- HER2/EGFR in Cancer Research
- Kruppel-like factors research
- Olfactory and Sensory Function Studies
- Extracellular vesicles in disease
- Connective Tissue Growth Factor Research
- Delphi Technique in Research
- Central Venous Catheters and Hemodialysis
Henry Ford Hospital
2014-2024
Henry Ford Health System
2010-2023
Washington University in St. Louis
2014
SUNY Upstate Medical University
2008
Ann Arbor Center for Independent Living
2007
University of Cape Town
1994
Red Cross War Memorial Children's Hospital
1994
Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates because an incomplete understanding biological mechanisms that lead to keloids. The purpose this project was examine keloid pathogenesis from epigenome perspective DNA methylation. Genome-wide profiling used Infinium HumanMethylation450 BeadChip interrogate 6 fresh and normal samples 12 anonymous donors. A...
In head and neck squamous cell cancer (HNSCC), four intrinsic subtypes (or groups) have been identified, each one possesses a unique biology that will require specific treatment strategies. We previously reported mesenchymal (group 2) tumors exhibit reduced levels of Trop2 expression. this study, we investigated the functional role in HNSCC find loss results autocrine activation EGFR family member ErbB3 via neuregulin-1. localizes to both surface cytosol cells forms complex with...
Objectives/Hypothesis To obtain biological insight into keloid pathogenesis and treatment using pathway analysis of genome‐wide differentially methylated gene profiles between normal skin. Study Design Prospective cohort. Methods Genome‐wide profiling was previously done, with institutional review board approval, on six fresh skin tissue samples, the Infinium HumanMethylation450 BeadChip kit. Statistically significant cytosine‐phosphodiester bond‐guanines (CpGs, n = 197) mapped to 152 genes....
Abstract Objectives/Hypothesis: The objective of this study was to review the outcomes scaphocephaly management. We hypothesized that differential treatment based on age at correction and degree severity yields consistently satisfying results while reducing operative morbidity. Study Design: Retrospective patient record review. Methods: Three cranial vault–remodeling procedures with varying levels aggressiveness (limited‐access, partial, total cranial‐vault remodeling) were performed...
To generate novel insights and hypotheses in keloid development from potential master regulators.Prospective cohort.Six fresh six normal skin samples 12 anonymous donors were used a prospective cohort study. Genome-wide profiling was done previously on the using Infinium HumanMethylation450 BeadChip (Illumina, San Diego, CA). The 190 statistically significant CpG islands between tissue mapped to 152 genes (P < .05). top 10 (VAMP5, ACTR3C, GALNT3, KCNAB2, LRRC61, SCML4, SYNGR1, TNS1, PLEKHG5,...
Modern microsurgical techniques enable en bloc resection of complex skull base tumors. Anterior cranial surgery, particularly, has been associated with a high rate postoperative cerebrospinal fluid (CSF) leak, meningitis, intracranial abscess, and pneumocephalus. We introduce simple modifications to already existing surgical strategies designed minimize the incidence CSF leak morbidity mortality.Medical records from 1995 2013 were reviewed in accordance Institutional Review Board. identified...
Objective The goal was to determine the prevalence of high‐risk HPV16 using saliva in a screening population Detroit, Michigan. Materials and Methods Real‐time quantitative polymerase chain reaction applied detect DNA from 349 subjects without head neck cancer (HNC), 156 with HNC, 19 controls. Cut points for human papilloma virus (HPV) positivity were >0 >0.001 copy/cell. Proportions compared between groups exact χ 2 or Fisher tests ( P <. 05). Results At cut point >0, each group...
Background: Comparing keloid treatment modalities and assessing response to treatments may be predicted by a better classification system. Objectives: To develop validate the Detroit Keloid Scale (DKS), standardized method of assessment. Methods: Forty-seven physicians were polled DKS. The scale was validated in 52 patients against Vancouver Scar (VSS), Patient Observer Assessment (POSAS), Dermatology Life Quality Index (DLQI). Results: inter-rater reliability "substantial" for observer DKS...
Effective treatment of keloids is challenging because the recurrence rate after surgical excision high. Data on best practices are lacking.To investigate earlobe based a postoperative intralesional corticosteroid injection protocol.Retrospective chart review was performed from January 1, 2005, to March 31, 2016, patients who had ear within departments dermatology, otorhinolaryngology, and plastic surgery. The number injections recorded, reported by patient, efficacy an protocol...
Mastery of the anatomy and embryology normal cleft upper lip, primary palate, secondary palate is an essential foundation for grasping techniques in aesthetic reconstruction lip defects. The surgical goals repairing deformities are to address deficiencies defect, restore static dynamic anatomy, reshape nasal deformity, leave a natural-appearing scar that mimics contours philtral components. An additional goal improve skeletal alignment retention teeth vicinity alveolar cleft. There...
Objectives: The aim of this research is to understand the importance female career mentors, co-residents, and program directors/chairs current otolaryngology residents when applying residency. safety in workplace was also investigated. Methods: Surveys were sent via electronic mail 119 programs, directors asked distribute them residents. Using Likert scale, participants ranked various factors creating a rank list, particular, mentors leadership positions. Demographic information, geographic...
The field of facial plastic and reconstructive surgery (FPRS) is an incredibly diverse, multispecialty that seeks innovative novel solutions for the management physical defects on head neck. To aid in advancement medical surgical treatments these defects, there has been a recent emphasis importance translational research. With technological advancements, are now myriad research techniques widely accessible physician scientist use Such include integrated multiomics, advanced cell culture...
Sjögren syndrome is a systemic autoimmune disease characterized by lacrimal and salivary gland inflammation resulting in dry eyes mouth. Although it common disease, diagnosis can be challenging due to its heterogeneous presentation. A positive minor biopsy mandatory fulfill the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for primary patients who are seronegative anti-SSA/Ro antibodies. The objective our study was evaluate...
In this study, we aimed to evaluate mir-31-5p as a prognostic biomarker of keloid disease (KD) recurrence using retrospective, treatment naïve, surgical cohort head and neck KD cases from Henry Ford Health.