A5008629721- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Gut microbiota and health
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- SARS-CoV-2 and COVID-19 Research
- Iron Metabolism and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Crystallography and molecular interactions
- COVID-19 and healthcare impacts
- Family Support in Illness
- Microbial Community Ecology and Physiology
- Plant-Microbe Interactions and Immunity
- COVID-19 and Mental Health
- Isotope Analysis in Ecology
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent Sexual and Reproductive Health
University of Bristol
2019-2024
Medical Research Council
2020-2024
MRC Epidemiology Unit
2021-2022
University Medical Center Groningen
2022
University of Reading
2017-2020
UNSW Sydney
2014
Abstract Numerous observational studies have attempted to identify risk factors for infection with SARS-CoV-2 and COVID-19 disease outcomes. Studies used datasets sampled from patients admitted hospital, people tested active infection, or who volunteered participate. Here, we highlight the challenge of interpreting evidence such non-representative samples. Collider bias can induce associations between two more variables which affect likelihood an individual being sampled, distorting these in...
<ns3:p>Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed published. To make this rich source results more accessible, we have manually curated database CpG-trait (with p<1x10<ns3:sup>-4</ns3:sup>) from...
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed published. To make this rich source results more accessible, we have manually curated database CpG-trait (with p<1x10 -4) from published EWAS, each assaying over...
Objectives: The biological mechanisms linking diet-related obesity and depression remain unclear. Therefore, we examined the impact of high-fat diet (HFD) on murine behaviour, intestinal microbiome, brain metabolome, neuropeptide Y (NPY) expression, dipeptidyl peptidase-4 (DPP-4) activity.Methods: Male C57Bl/6J mice were fed an HFD (60 kJ% from fat) or control (12 for 8 weeks, followed by behavioural phenotyping. Caecal microbiome was analysed 16S rDNA sequencing, metabolome 1H nuclear...
Abstract Observational data on COVID-19 including hypothesised risk factors for infection and progression are accruing rapidly, often from non-random sampling such as hospital admissions, targeted testing or voluntary participation. Here, we highlight the challenge of interpreting observational evidence samples population, which may be affected by collider bias. We illustrate these issues using UK Biobank in individuals tested highly selected a wide range genetic, behavioural,...
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via butyrate production. Human bariatric surgery data suggest the gut-brain axis is also involved this process, but underlying mechanisms remain unknown.We compared effect of fecal transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin (SERT) binding as well stable isotope-determined...
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed pub-lished. To make this rich source results more accessible, we have manually curated database CpG-trait (with p&lt;1x10-4) from published EWAS, each...
Two new pincer ligands have been developed that contain a central N-heterocyclic carbene (NHC) moiety linked to two pendant pyrazole groups by either methylene (NCN(me)) or ethylene (NCN(et)) chain. The coordination of these rhodium and iridium resulted in variety binding modes. Tridentate the was observed complexes [Rh(NCN(me))(COD)]BPh4 (8), [Ir(NCN(me))(COD)]BPh4 (10), [Rh(NCN(et))(CO)2]BPh4 (13), [Ir(NCN(me))(CO)2]BPh4 (14), monodentate NHC for [Ir(NCN(me))2(COD)]BPh4 (11)...
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to utero growth factors successive pregnancies may impact later life via persistent DNA methylation alterations. We investigated Illumina array data each 16 cohorts (8164 newborns) European, African, Latino ancestries from the Pregnancy Childhood Epigenetics Consortium. Meta-analyzed demonstrated systematic variation 341 CpGs (FDR adjusted P < 0.05) 1107 regions. Forty...
Objectives: Imbalanced nutrition and obesity are risk factors for depression, a relationship that in rodents can be modeled by depression-like behavior response to high-fat diet (HFD). In this work, we examined the role of intestinal microbiota adipocytokine leptin as potential mediators effects HFD induce anhedonia-like reduce self-care mice.Methods: Male mice were fed control or (60 kJ% from fat) period 4 weeks, after which behavioral tests molecular analyses (gut microbiome composition,...
Suboptimal nutrition in pregnancy is associated with worse offspring cardiometabolic health. DNA methylation may be an underlying mechanism. We meta-analyzed epigenome-wide association studies (EWAS) of maternal dietary glycemic index and load cord blood methylation.We calculated from food frequency questionnaires ran EWAS on 2,003 mother-offspring pairs three cohorts. Analyses were additionally stratified by BMI categories. looked-up the findings traits as well birth weight child BMI....
Abstract Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biologic mechanisms underlying these associations largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve datasets from ten pregnancy cohorts (N=5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine during cord blood. Children whose mothers reported higher levels of cumulative exhibited differential...