A5013190946- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Atmospheric and Environmental Gas Dynamics
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Nutritional Studies and Diet
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Folate and B Vitamins Research
- Dermatology and Skin Diseases
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health disparities and outcomes
- Cancer-related gene regulation
- Obesity, Physical Activity, Diet
- Smoking Behavior and Cessation
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Evolutionary Psychology and Human Behavior
- Cardiovascular Disease and Adiposity
- Gene expression and cancer classification
University of Bristol
2018-2023
Medical Research Council
2020-2023
University Medical Center Groningen
2022
MRC Epidemiology Unit
2018-2022
MRC Integrative Epidemiology Unit
2019
University of Oulu
2018
<ns3:p>Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed published. To make this rich source results more accessible, we have manually curated database CpG-trait (with p<1x10<ns3:sup>-4</ns3:sup>) from...
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed published. To make this rich source results more accessible, we have manually curated database CpG-trait (with p<1x10 -4) from published EWAS, each assaying over...
Abstract Linking epigenetic marks to clinical outcomes improves insight into molecular processes, disease prediction, and therapeutic target identification. Here, a statistical approach is presented infer the architecture of complex disease, determine variation captured by effects, estimate phenotype-epigenetic probe associations jointly. Implicitly adjusting for correlations, data structure (cell-count or relatedness), single-nucleotide polymorphism (SNP) marker association estimates in...
Whether smoking-associated DNA methylation has a causal effect on lung function not been thoroughly evaluated. We first investigated the effects of 474 CpGs forced expiratory volume in 1 s (FEV1) UK Biobank (n = 321,047) by using two-sample Mendelian randomization (MR) and then replicated this investigation SpiroMeta Consortium 79,055). Second, we used two-step MR to investigate whether mediates smoking FEV1. Lastly, evaluated presence horizontal pleiotropy assessed there is any evidence for...
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, increase in availability measures population-based cohorts case-control has resulted a dramatic expansion number EWAS being performed pub-lished. To make this rich source results more accessible, we have manually curated database CpG-trait (with p&lt;1x10-4) from published EWAS, each...
Abstract Identifying genomic regions pertinent to complex traits is a common goal of genome-wide and epigenome-wide association studies (GWAS EWAS). GWAS identify causal genetic variants, directly or via linkage disequilibrium, EWAS variation in DNA methylation associated with trait. While principle will only detect variants due genes, can also genes confounding, reverse causation. We systematically compare ( N > 50,000) 4500) results 15 traits. evaluate if the gene ontology terms flagged...
It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel sites in blood, with repeated measurements, appraise the putative role cancer development.
Spousal comparisons have been proposed as a design that can both reduce confounding and estimate effects of the shared adulthood environment. However, assortative mating, process by which individuals select phenotypically (dis)similar mates, could distort associations when comparing spouses. We evaluated use spousal comparisons, in within-spouse pair (WSP) model, for aetiological research such genetic association studies. demonstrated WSP model but may be susceptible to collider bias arising...
<ns4:p><ns4:bold>Background:</ns4:bold>Genome-wide association studies have identified genetic variants associated with coronary artery disease (CAD) in adults – the leading cause of death worldwide. It often occurs later life, but may impact CAD-relevant phenotypes early and throughout life-course. Cohorts longitudinal data on thousands individuals are letting us explore antecedents this adult disease.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>149 metabolites, a focus lipidome, measured...
Abstract Molecular quantitative trait loci (molQTL), which can provide functional evidence on the mechanisms underlying phenotype-genotype associations, are increasingly used in drug target validation and safety assessment. In particular, protein abundance QTLs (pQTLs) gene expression (eQTLs) most commonly for this purpose. However, questions remain how to best consolidate results from pQTLs eQTLs validation. study, we combined blood cell-derived plasma-derived form QTL pairs representing...
<ns4:p><ns4:bold>Background:</ns4:bold>Genome-wide association studies have identified genetic variants associated with coronary artery disease (CAD) in adults – the leading cause of death worldwide. It often occurs later life, but may impact CAD-relevant phenotypes early and throughout life-course. Cohorts longitudinal data on thousands individuals are letting us explore antecedents this adult disease.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>148 metabolites, a focus lipidome, measured...
Abstract DNA methylation changes in peripheral blood have been identified relation to lung cancer risk. However, the causal nature of these associations remains be fully elucidated. Meta-analysis four epigenome-wide association studies (918 cases, 918 controls) revealed differential at 16 CpG sites (FDR < 0.05) A two-sample Mendelian randomization analysis, using genetic instruments for 14 sites, and 29,863 cases 55,586 controls from TRICL-ILCCO consortium, was performed appraise role on...
<ns4:p>Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact exposures on outcomes. Evidence suggests a role excess adipose tissue (adiposity) many health However, this body work has not been systematically appraised.</ns4:p><ns4:p> </ns4:p><ns4:p> We reviewed and meta-analysed results from MR studies investigating association between adiposity outcomes prior to SARS-CoV-2/COVID-19 pandemic (PROSPERO: <ns4:ext-link...
<ns3:p>Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact exposures on outcomes. Evidence suggests a role excess adipose tissue (adiposity) many health However, this body work has not been systematically appraised.</ns3:p><ns3:p> </ns3:p><ns3:p> We reviewed and meta-analysed results from MR studies investigating association between adiposity outcomes prior to SARS-CoV-2/COVID-19 pandemic (PROSPERO: <ns3:ext-link...
ABSTRACT Following years of epigenome-wide association studies (EWAS), traits analysed to date tend yield few associations. Reinforcing this observation, we conducted EWAS on 400 and 16 yielded at least one the conventional significance threshold (P<1×10 −7 ). To investigate why is low, formally estimated proportion phenotypic variation captured by 421,693 blood derived DNA methylation markers (h 2 ) across all traits. The mean h was zero, with evidence for regular cigarette smoking...
Abstract Whether smoking-associated DNA methylation has a causal effect on lung function not been thoroughly evaluated. We investigated the effects of 474 CpGs forced expiratory volume in one second (FEV 1 ) two-sample Mendelian randomization (MR) using quantitative trait loci and genome-wide association data for FEV . found evidence possible at 18 (p<1.2×10 −4 ). Replication analysis supported three (cg21201401 ( ZGPAT ), cg19758448 PGAP3 cg12616487 AHNAK (p<0.0028). did clearly...
Abstract Comparisons between cohabitating spouses have been proposed as an aetiological design method to reduce confounding and evaluate effects of the shared adulthood environment. However, assortative mating, a phenomenon where individuals select phenotypically similar mates, could distort associations. We evaluated use spousal comparisons, in within-spouse pair (WSP) model, for epidemiological research. Using directed acyclic graphs simulations, we demonstrated that WSP model can if are...
Abstract Identifying the genes, properties of these genes and pathways to understand underlying biology complex traits responsible for differential health states in population is a common goal epigenome-wide genome-wide association studies (EWAS GWAS). GWAS identify genetic variants that effect trait interest or are linkage disequilibrium with true causal variants. EWAS variation DNA methylation, molecular phenotype, associated interest. Therefore, while principle will only detect within...