A5055704111- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Asthma and respiratory diseases
- Child and Adolescent Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Parasites and Host Interactions
- Drug Transport and Resistance Mechanisms
- Prenatal Substance Exposure Effects
- Chronic Disease Management Strategies
- Lysosomal Storage Disorders Research
- Genetics, Bioinformatics, and Biomedical Research
- Health, Environment, Cognitive Aging
- Nutrition and Health in Aging
- Calpain Protease Function and Regulation
- Folate and B Vitamins Research
- Smoking Behavior and Cessation
- Obesity, Physical Activity, Diet
- Glycosylation and Glycoproteins Research
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
University of Southampton
2020-2024
Southampton General Hospital
2024
Misgav Ladach
2022
Universidad de Salamanca
2022
MRC Lifecourse Epidemiology Unit
2020
NIHR Southampton Biomedical Research Centre
2020
University Hospital Southampton NHS Foundation Trust
2020
Background Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, DNA methylation proposed as a mediating mechanism. Here, we examined the relationships between dysglycaemia at 24 to 28 weeks’ gestation and in neonates whether dietary physical activity intervention pregnant women obesity modified signatures dysglycaemia. Methods findings We investigated 557 women, recruited 2009 2014 from...
Abstract Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify marks offspring associated with father’s preconception smoking. Methods conducted epigenome-wide association (EWAS) the RHINESSA cohort (7–50 years) on any smoking ( n = 875 offspring) and pubertal onset < 15 years 304), using Infinium...
BackgroundAscaris infections, with a worldwide prevalence above 10%, can cause respiratory pathology. However, long-term effects on lung function in humans are largely unknown.ObjectiveWe investigated the associations of Ascaris exposure function, asthma, and DNA methylation.MethodsSerum IgG antibodies were measured 671 adults aged 18 to 47 years (46% women) from Aarhus, Bergen, Tartu RHINESSA study centers. Seropositivity was defined as 90th percentile. Linear logistic regressions used...
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to utero growth factors successive pregnancies may impact later life via persistent DNA methylation alterations. We investigated Illumina array data each 16 cohorts (8164 newborns) European, African, Latino ancestries from the Pregnancy Childhood Epigenetics Consortium. Meta-analyzed demonstrated systematic variation 341 CpGs (FDR adjusted P < 0.05) 1107 regions. Forty...
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Perturbations in the intrauterine environment can result lifelong consequences for metabolic health during postnatal life. Intrahepatic cholestasis of pregnancy (ICP) predispose offspring to disease adulthood, likely due a combination effects increased bile acids, maternal dyslipidemia and deranged fetal lipid homeostasis. Whereas ursodeoxycholic acid (UDCA) is commonly used treatment ICP, no studies have yet addressed whether it also prevent ICP fetoplacental unit. We therefore analyzed...
Many epidemiological studies have linked low birthweight to an increased risk of non-communicable diseases (NCDs) in later life, with epigenetic proceseses suggested as underlying mechanism. Here, we sought identify neonatal methylation changes associated birthweight, at the individual CpG and genomic regional level, whether birthweight-associated signatures were specific maternal factors. Using Illumina Human Methylation EPIC array, assessed DNA cord blood 557 483 infants from UK...
Abstract Recent studies implicate maternal gestational diabetes mellitus (GDM) in differential methylation of infant DNA. Folate and vitamin B12 play a role DNA methylation, these vitamins may also influence GDM risk. The aims this study were to determine folate status obese pregnant women investigate associations between status, dysglycaemia neonatal at cytosine-phosphate-guanine sites previously observed be associated with dysglycaemia. Obese who participated the UK Pregnancies Better...
<b>Background:</b> Early life paternal adverse environment has significant health consequences for the of his offspring. Children born from father's who start smoking before age 15 have three-fold risk developing asthma, lower lung function and increased BMI. We hypothesised that underlying mechanism could be in part explained by epigenetic programming. <b>Aim:</b> To identify marks offspring associated with preconception smoking. <b>Methods:</b> An epigenome-wide association studie (EWAS)...
Abstract Rationale Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are however limited. We aim to identify marks offspring associated with father’s preconception smoking. Methods conducted epigenome-wide association (EWAS) the RHINESSA cohort on any smoking (N=875 offspring) and pubertal onset <15 years (N=304), using Infinium MethylationEPIC Beadchip...
ABSTRACT Background Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used broad definition “doctor-diagnosed asthma”, thereby diluting genetic signals by not considering heterogeneity. The objective our study was to identify associates childhood wheezing phenotypes. Methods We conducted novel multivariate GWAS meta-analysis phenotypes jointly derived using unbiased analysis data collected from birth 18 years in 9,568...
Abstract Background/Aims Sarcopenia and muscle ageing are associated with substantial morbidity mortality for the individual significant costs to healthcare budgets. However, if we can identify those at particular risk of decline it may be possible intervene, prevent further deterioration improve musculoskeletal health population. DNA methylation accumulates across lifecourse provides basis biological clocks, generating a measure age acceleration (i.e. that an is biologically older or...