A5091544525- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Reproductive Health and Technologies
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pancreatitis Pathology and Treatment
- Dietetics, Nutrition, and Education
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
London Women's Clinic
2021-2022
King's College London
2017-2020
Obesity is a heterogeneous phenotype and risk associations to non-communicable diseases such as cardiovascular disease type 2 diabetes are influenced by several factors. The paternal metabolic status at the time of conception influences offspring susceptibility developing obesity adiposity-associated cardiometabolic disease. Cholestatic liver characterized raised circulating serum bile acid levels dyslipidemia, commonly treated with ursodeoxycholic (UDCA). We hypothesized that cholestasis...
Perturbations in the intrauterine environment can result lifelong consequences for metabolic health during postnatal life. Intrahepatic cholestasis of pregnancy (ICP) predispose offspring to disease adulthood, likely due a combination effects increased bile acids, maternal dyslipidemia and deranged fetal lipid homeostasis. Whereas ursodeoxycholic acid (UDCA) is commonly used treatment ICP, no studies have yet addressed whether it also prevent ICP fetoplacental unit. We therefore analyzed...
We used a mouse model of gestational hypercholanemia to investigate the use obeticholic acid (OCA), potent FXR agonist, as treatment for intrahepatic cholestasis pregnancy (ICP). The results demonstrate that OCA can improve fetal bile profile. This is relevant not only women with ICP but also who become pregnant while receiving other conditions such primary biliary cholangitis and nonalcoholic steatohepatitis.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Study question Are there differences in ovarian stimulation outcomes among different ethnicities the largest UK vitrified oocyte donation programme? Summary answer No significant were observed response between non-White and White ethnic donor groups. Only AMH baseline AFC correlated well with response. What is known already Ethnic disparities ART have received much attention recently. Studies based on national registries reported inferior for South Asian Black undergoing non-donor...
Abstract Study question Do established donor and recipient clinical markers predict pregnancy live birth rates (LBRs) in a vitrified oocyte donation programme? Summary answer Recipient BMI previous miscarriages predicted cumulative LBR. Likelihood of LBR was higher recipients donors aged 23–29 than 18–22. What is known already The influence age on ovarian reserve underlies the upper limit 35 years for UK donors. However, recent evidence suggests that aneuploidy follow an inverse U-shaped...