A5039522742- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Pregnancy and preeclampsia studies
- Energy and Environment Impacts
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- GDF15 and Related Biomarkers
- Neonatal Respiratory Health Research
- Urban Green Space and Health
- Adolescent and Pediatric Healthcare
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Prenatal Substance Exposure Effects
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Land Use and Ecosystem Services
- Child Abuse and Trauma
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
Barcelona Institute for Global Health
2020-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2020-2025
Universitat Pompeu Fabra
2021-2025
Instituto de Salud Carlos III
2023-2025
Institute for Research in Biomedicine
2018-2023
Universitat de Barcelona
2013-2023
Universitat Jaume I
2023
Universitat de València
2023
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2023
Center for Research in Environmental Epidemiology
2023
Oxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer's disease (AD). Studies have shown that brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid cell lines (LCLs) HCs investigate role resveratrol (RV) selenium (Se) reduction reactive oxygen species (ROS) generated after an injury. We studied whether these compounds elicited expression changes genes...
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild (677C > T polymorphism) increases risk complex traits, including neuropsychiatric disorders. Although low dietary folate impacts brain development, recent concerns have focused on high intake following food fortification increased vitamin use. Our goal was to determine whether during pregnancy affects...
A growing body of evidence suggests that meditation training may have a range salubrious effects, including improved telomere regulation. Telomeres and the enzyme telomerase interact with variety molecular components to regulate cell-cycle signaling cascades, are implicated in pathways linking psychological stress disease. We investigated effects intensive practice on these biomarkers by measuring changes length (TL), activity (TA), telomere-related gene (TRG) expression during 1-month...
The senescence-accelerated SAMP8 mouse is considered a useful non-transgenic model for studying aspects of progressive cognitive decline and Alzheimer's disease (AD). Using SAMR1 mice as controls, here we explored the effects 6 months voluntary wheel running in 10-month-old female mice. Exercise improved phenotypic features associated with premature aging (i.e., skin color body tremor) enhanced vascularization BDNF gene expression hippocampus compared controls. With aim identifying genes...
Chemicals are part of our daily lives, and we exposed to numerous chemicals through multiple pathways. Relevant scientific evidence contributing the regulation hazardous require a holistic approach assess simultaneous exposure compounds. Biomonitoring provides an accurate estimation very complex costly sampling campaigns. Finding efficient proxies predict risk chemical in humans is urgent need cover large areas populations at reasonable cost. We conducted exploratory study characterize human...
Meditation retreats are characterized by intensive or concentrated periods of meditation practice, commonly undertaken in a residential setting. Although research indicates that training can positively influence physical and mental health outcomes, the biological consequences retreat interventions relatively understudied. In this study, we examined month-long, silent on expression genes involved epigenetic modulation immune processes. We assessed gene changes experienced meditators attending...
Increasing evidence supports the role of placenta in neurodevelopment and onset neuropsychiatric disorders. Recently, mQTL iQTL maps have proven useful understanding relationships between SNPs GWAS that are not captured by eQTL. In this context, we propose part genetic predisposition to complex disorders acts through placental DNA methylation. We construct a public cis-mQTL database including 214,830 CpG sites calculated 368 fetal samples from INMA project, run cell type-, gestational age-...
Objective Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvolution to identify cell type-specific profiles, from five major blood types, associated with childhood ADHD symptoms. Methods We meta-analyses of methylome-wide association (MWAS) for symptoms (agerange=4-16 years) peripheral collected during and cord...
Fifteen to 20% of pregnant women may exceed the recommended intake folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here, we explored impact an FA-supplemented diet (5× FASD, containing five-fold higher FA recommended) during pregnancy on brain function murine offspring, elucidated mechanistic changes. We placed female C57BL/6 mice for one month control diets or 5× FASD before mating. Diets were maintained throughout...
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to utero growth factors successive pregnancies may impact later life via persistent DNA methylation alterations. We investigated Illumina array data each 16 cohorts (8164 newborns) European, African, Latino ancestries from the Pregnancy Childhood Epigenetics Consortium. Meta-analyzed demonstrated systematic variation 341 CpGs (FDR adjusted P < 0.05) 1107 regions. Forty...
A growing body of research shows that epigenetic mechanisms are critically involved in normal and pathological aging. The Senescence-Accelerated Mouse Prone 8 (SAMP8) can be considered a useful tool to better understand the dynamics global landscape during aging process since its phenotype is not fully explained by genetic factors. Here we investigated dysfunctional age-related transcriptional profiles programming enzymes hippocampus 2- 9-month-old SAMP8 female mice using...
Neuroinflammation is a risk factor for Alzheimer’s disease (AD). We sought to study the glial derangement in AD using diverse experimental models and human brain tissue. Besides classical pro-inflammatory cytokines, we analyzed chitinase 3 like 1 (CHI3L1 or YKL40) triggering receptor expressed on myeloid cells 2 (TREM2) that are increasingly being associated with astrogliosis microgliosis AD, respectively. The SAMP8 mouse model of accelerated aging traits showed elevated cytokines activated...
Abstract Adverse childhood experiences (ACEs, i.e., abuse, neglect, household dysfunction) represent a potential risk factor for wide range of long-lasting diseases and shorter life expectancy. We recently described 1-week residential group program, based on mindfulness training, artistic expression EMDR therapy, that significantly reduced PTSD-related symptoms increased attention/awareness-related outcomes in adolescent girls with multiple ACEs randomized controlled study. Since epigenetic...
Aging is characterized by a low-grade systemic inflammation that contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). However, little knowledge currently available on molecular processes leading chronic neuroinflammation. In this context, recent studies have described role chromatin regulators in and longevity including REST corepressor (Rcor)-2 factor, which seems be involved an inflammatory suppressive program. To assess impact Rcor2 age-related...
Many pregnant women have higher folic acid (FA) intake due to food fortification and increased vitamin use. It is reported that diets containing five-fold FA than recommended for mice (5xFASD) during pregnancy resulted in methylenetetrahydrofolate reductase (MTHFR) deficiency altered choline/methyl metabolism, with neurobehavioral abnormalities newborns. The goal determine whether these changes their origins the placenta embryonic development.Female are fed control diet or 5xFASD a month...
Food fortification and increased vitamin intake have led to higher folic acid (FA) consumption by many pregnant women. We showed that FA-supplemented diet in mice (fivefold FA than the recommended level (5xFASD)) hyperactivity-like behavior memory impairment pups. Disturbed choline/methyl metabolism altered placental gene expression were identified. The aim of this study was examine impact 5xFASD on brain at two developmental stages, postnatal day (P) 30 embryonic (E) 17.5. Female C57BL/6...