A5050280443- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Iron Metabolism and Disorders
- Ovarian function and disorders
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
- Telomeres, Telomerase, and Senescence
- Cardiovascular Disease and Adiposity
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hemoglobinopathies and Related Disorders
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Histiocytic Disorders and Treatments
University of Oulu
2015-2025
The Kids Research Institute Australia
2022
The University of Western Australia
2022
Imperial College London
2022
Biocenter Finland
2020
Oulu University Hospital
2015-2016
Ageing is a biological and psychosocial process related to diseases mortality. It correlates with changes in DNA methylation (DNAm) all human tissues. Therefore, epigenetic markers can be used estimate age using DNAm profiling across tissues.We developed Bioconductor package that allows computation of several existing adult/childhood gestational clocks. Functions visualize the prediction versus chronological correlation between clocks are also available as well other features, such missing...
Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy growth, we report genome-wide association analyses in the ( n = 65,405), 61,228) paternal 52,392) genomes, yielding 40 independent signals. Twenty-six signals are classified fetal, four three maternal. parent-of-origin effect seen near KCNQ1 . Genetic correlation colocalization reveal overlap with birth genetics, but 12 loci predominantly or only affecting...
The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts across Europe and Australia to facilitate studies on the influence of early-life exposures later health outcomes. A major product this has been establishment FAIR (findable, accessible, interoperable reusable) resource known as EU Child Cohort Network. Here we focus Network's core variables. These are set basic variables, derivable by majority participating frequently used...
Abstract Common variants of human fat mass- and obesity-associated gene Fto have been linked with higher body mass index, but the biological explanation for link has remained obscure. Recent findings suggest that these affect homeobox protein IRX3. Here we report FTO a role in white adipose tissue which modifies its response to high-fat feeding. Wild type -deficient mice were exposed standard or diet 16 weeks after metabolism, behavior morphology analyzed together adipokine levels relative...
Children's biological age does not always correspond to their chronological age. In the case of BMI trajectories, this can appear as phase variation, which be seen shift, stretch, or shrinking between trajectories. With maturation thought a process moving towards final state - adult BMI, we assessed whether children divided into latent groups reflecting similar maturational BMI. The were characterised by early factors and time-related features We used data from two general population birth...
Genetic variants in the fat mass- and obesity-associated gene Fto are linked to onset of obesity humans. The causal role FTO protein is supported by evidence obtained from transgenic mice; however, underlying molecular pathways pertaining have yet be established. In this study, we investigate mouse brown adipose tissue browning process white tissue. We analyze distinct structural factors depots Fto-deficient mice under normal obesogenic conditions. report significant alterations morphology...
Aging | doi:10.18632/aging.203872. Anna Freni-Sterrantino, Giovanni Fiorito, Angelo D'Errico, Oliver Robinson, Marianna Virtanen, Leena Ala-Mursula, Marjo-Riitta Järvelin, Justiina Ronkainen, Paolo Vineis
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to utero growth factors successive pregnancies may impact later life via persistent DNA methylation alterations. We investigated Illumina array data each 16 cohorts (8164 newborns) European, African, Latino ancestries from the Pregnancy Childhood Epigenetics Consortium. Meta-analyzed demonstrated systematic variation 341 CpGs (FDR adjusted P < 0.05) 1107 regions. Forty...
Objective and methods The impact of the rs9939609 FTO variant on cardiovascular events was investigated in 19-year follow-up subjects recruited to OPERA study.Results A total 212 disease (CVD) 152 coronary heart (CHD) or deaths occurred during follow-up. logistic regression analysis revealed that among AA genotype incidence CHD (OR 1.905; 95% CI 1.250–2.903, p = 0.001) CVD 1.849; 1.265–2.702, 0.003) death significantly higher when adjusted for age, sex, study group. After further adjustment...
The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle living environments. These correspond to changes our "modern" postwar societies globally characterized by rural-to-urban migration, modernization agricultural practices, transportation, climate change, aging. Evidence suggests that these are related each other, although the social biological mechanisms as well their interactions yet be uncovered....
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist liver (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol. Our aim was to elucidate the roles oxysterols in regulation cholesterol transporters. We measured serum volunteers dosed with rifampicin 600 mg/day versus placebo for a week analysed expression transporters mononuclear cells. The effect 4βHC on transport studied human primary monocyte-derived macrophages foam...
Leucocyte telomere length (LTL) has been associated with nonalcoholic fatty liver disease (NAFLD), but the evidence is imperfect. Furthermore, fibrosis shown to correlate mortality and recent studies have also found associations LTL suggesting that may additional prognostic value in diseases. Our objective was study association of NAFLD evaluate prognosis subjects. Study subjects (n = 847) were middle-aged hypertensive patients. All participants evaluated for their measured at baseline....
Abstract STUDY QUESTION Can a genome-wide association study (GWAS) meta-analysis, including large sample of young premenopausal women from founder population Northern Finland, identify novel genetic variants for circulating anti-Müllerian hormone (AMH) levels and provide insights into single-nucleotide polymorphism enrichment in different biological pathways tissues involved AMH regulation? SUMMARY ANSWER The meta-analysis identified total six loci associated with at P &lt; 5 × 10−8,...
Abstract Background Globally, one in ten babies is born preterm (<37 weeks), and 1–2% at very low birth weight (VLBW, <1500 g). As adults, they are increased risk for a plethora of health conditions, e.g., cardiometabolic disease, which may partly be mediated by epigenetic regulation. We compared blood DNA methylation between young adults VLBW controls. Methods 157 subjects 161 controls term, from the Helsinki Study Very Low Birth Weight Adults, were assessed peripheral venous levels...
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a rare disease with poor prognosis. By contrast, cancer common in any elderly population and leading killer, but now often curable. Of note, whereas IPF driven by cellular senescence, characterized uncontrolled cell division. Using data available from two large biobank-based studies (Finnish FinnGen study UK biobank), we conducted comprehensive analysis of the shared genetic background cancer. In sample 218,792 Finns complete longitudinal...
Abstract Objectives Type 2 diabetes (T2D) and comorbid depression challenges clinical management particularly in individuals with overweight. We aim to explore the shared etiology, via lifecourse adiposity, between T2D depression. Methods used data from birth until 46years Northern Finland Birth Cohort 1966 ( n = 6,372; 53.8% females). conducted multivariate analyses on three outcomes: (4.2%), (19.2%) as comorbidity (1.8%). (i) Path analysis clarify time-dependent body mass index (BMI)...
Telomeres are DNA-protein complexes that protect chromosome ends from DNA damage and surrogate biomarkers of cellular aging. Current evidence, almost entirely cross-sectional observations, supports negative associations between leukocyte telomere length (LTL) adverse lifestyle factors cardiometabolic risk factors. Polycystic ovary syndrome (PCOS), the most common gynecological endocrine disorder, is associated with inflammation oxidative stress, both accelerated attrition. We therefore...
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in newborn possible long-term consequences. To test this humans, we meta-analyzed epigenome-wide of offspring 3,967 cord blood 1,534 children 1,962 adolescent whole-blood samples derived 10 cohorts. was measured using Illumina Infinium...
Understanding the biological mechanisms behind multimorbidity patterns in adolescence is important as they may act intermediary risk factor for long-term health. We aimed to explore relationship between prenatal exposures and adolescent's psycho-cardiometabolic traits mediated through epigenetic biomarkers, using structural equation modeling (SEM). used data from mother-child dyads pregnancy adolescents at 16-17 years two prospective cohorts: Northern Finland Birth Cohort 1986 (NFBC1986)...