A5047585126- Birth, Development, and Health
- Health disparities and outcomes
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Older Adults Driving Studies
- Physical Activity and Health
- Migration, Aging, and Tourism Studies
- Health, Environment, Cognitive Aging
- Sleep and related disorders
- Urban Transport and Accessibility
- Intergenerational Family Dynamics and Caregiving
- Hearing, Cochlea, Tinnitus, Genetics
- Gestational Diabetes Research and Management
- Bone fractures and treatments
- Advanced Glycation End Products research
- Workplace Health and Well-being
- Global Health Care Issues
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
Folkhälsans Forskningscentrum
2016-2025
University of Helsinki
2020-2025
Finnish Institute for Health and Welfare
2023-2025
And Technology Research (United Kingdom)
2023
Medicinska Understödsföreningen Liv och Hälsa
2023
Finska Läkaresällskapet
2023
National University of Singapore
2023
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2020
University of Jyväskylä
2007-2017
Research Institute for Olympic Sports
2011
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body evidence suggests that exposure adverse stressors during early leads developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related inequalities from onwards. To address these public challenges, many European pregnancy childhood cohorts have been established over last 30 years. The enormous...
Objectives To study the relationship between physical performance and sense of autonomy in outdoor activities with life‐space mobility—the spatial area a person purposefully moves through daily life—in community‐dwelling older people. Design Cross‐sectional analyses baseline data Life‐Space Mobility Old Age cohort study. Setting Structured interviews participants' homes. Participants Community‐dwelling people aged 75 to 90 (N = 848). Measurements Sense outdoors (Impact on Participation...
Objectives: To examine the association between life-space mobility and different dimensions of depressive symptoms among older community-dwelling people.Methods: Cross-sectional analyses baseline data 'Life-Space Mobility in Old Age' cohort study were carried out. The participants women men aged 75–90 years (N = 848). Data gathered via structured interviews participants' home. Life-space (the University Alabama at Birmingham (UAB) Life-Space Assessment – questionnaire) (Centre for...
Summary This cross‐sectional study aimed to investigate whether body fat distribution, physical activity levels and dietary intakes are associated with insomnia and/or obstructive sleep apnea among overweight middle‐aged men. Participants were 211 Finnish men aged 30–65 years. Among the 163 or obese participants, 40 had only, 23 24 comorbid 76 without disorder. The remaining 48 participants normal weight Fat mass, of diet assessed by dual‐energy X‐ray densitometry, questionnaire 3‐day food...
The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts across Europe and Australia to facilitate studies on the influence of early-life exposures later health outcomes. A major product this has been establishment FAIR (findable, accessible, interoperable reusable) resource known as EU Child Cohort Network. Here we focus Network's core variables. These are set basic variables, derivable by majority participating frequently used...
We investigated the potential involvement of miRNAs in developmental programming cardiovascular diseases (CVD) by maternal obesity. Serum were measured individuals from Helsinki Birth Cohort (with known body mass index), and a mouse model was used to determine causative effects obesity during pregnancy ischemia-reperfusion on offspring cardiac miRNA expression release. miR-15b-5p levels increased sera males born mothers with higher BMI hearts adult mice obese dams. In an ex-vivo perfused...
High body mass index (BMI) is known to be associated with elevated blood pressure (BP). The present study aims determine the relative importance of two components BMI, fat and lean index, on BP levels. We assessed composition bioimpedance performed 24 hour ambulatory measurements in 534 individuals (mean age 61 ± 3 years) who had no cardiovascular medication. Fat were calculated analogously BMI as or (kg) divided by square height (m2). Both showed a positive, small moderate relationship all...
Abstract Background Few studies have examined longitudinal changes in lifestyle-related factors and frailty. Methods We the association between individual lifestyle (exercise, diet, sleep, alcohol, smoking body composition), their sum at baseline, change over 17-year follow-up rate of frailty index values using linear mixed models a cohort 2,000 participants aged 57–69 years baseline. Results A higher number healthy baseline was associated with lower levels but not its from late midlife into...
The skeleton is recognized as an important player in energy metabolism through its interactions with other tissues. Whether the association of osteocalcin glucose age dependent has not been fully addressed. objective study was to examine age-specific between different forms and adipokines. This a family-based across three generations. conducted at university laboratory. Sixty-four daughter-premenopausal mother-maternal grandmother trios participated study. Fasting plasma insulin...
Objectives To explore the associations between self‐reported hearing problems and physical performance difficulties in mobility activities of daily living ( ADL s) community‐dwelling older adults. Design Cross‐sectional cohort study. Setting Community. Participants Men women aged 75 to 90 (N = 848). Measurements Structured face‐to‐face interviews assess perceived presence noise, (moving indoors, stair‐climbing, 0.5‐km walk, 2‐km walk), s instrumental s. The Short Physical Performance Battery...
Life-space mobility reflects individuals' actual and engagement with society. Difficulty in hearing is common among older adults can complicate participation everyday activities, thus restricting life-space mobility. The aim of this study was to examine whether self-reported predicts changes adults. We conducted a prospective cohort community-dwelling aged 75–90 years (n = 848). At-home face-to-face interviews at baseline telephone follow-up were used. Participants responded standardized...
Abstract Early life stress has far-reaching effects on various aspects of well-being in later life, but whether it impacts resilience, i.e., the ability to tolerate hardship, old age remains unclear. We investigated childhood adversities and home atmosphere are associated with resilience directly or indirectly through poorer physical psychological functioning late middle age. The data comprised 1176 persons born 1934–1944 were collected over a 17-year follow-up 2001–2018. Childhood (greater...
ABSTRACT Physical activity (PA) may delay the onset of age‐related diseases by decelerating biological aging. We investigated association between leisure‐time physical (LTPA) and metabolomics‐based aging markers (MetaboAge MetaboHealth) in late midlife during 16 years follow‐up. At 16‐year follow‐up, we also device‐based PA MetaboAge MetaboHealth. included 1816 individuals (mean age 61.6 years) from Helsinki Birth Cohort Study at baseline followed them up for 5 ( n = 982) 744), respectively....
Physical activity might be able to delay the aging process by reducing levels of advanced glycation end-products (AGEs). However, influence physical on AGEs remains unclear. We investigated associations between leisure time (LTPA) in late midlife and change LTPA during a 15-year follow up old age. analyzed 767 participants from Helsinki Birth Cohort Study. was measured with validated questionnaire The were skin autofluorescence General linear models restricted cubic regression spline used...
Abstract A better understanding of how bone growth is regulated during peripuberty important for optimizing the attainment peak mass and prevention osteoporosis in later life. In this report we used hierarchical models to evaluate associations insulin-like factor 1 (IGF-1), estradiol (E2), testosterone (T) with peripubertal a 7-year longitudinal study. Two-hundred fifty-eight healthy girls were assessed at baseline (mean age 11.2 years) 1, 2, 3.5, 7 years. Serum concentrations IGF-1, E2, T...
The aim of this study is to examine whether a persons' most frequently used mode transportation associated with life-space mobility and the association differs between persons or without walking difficulties.Life-space was measured Life-Space Assessment in 848 community-dwelling men women aged 75 90 years. Six separate groups were formed according (car driver, car passenger, public transportation) combined presence absence difficulties 2 km.Car drivers had highest scores, passengers lowest...
Most studies examining the associations between body composition and health-related quality of life (HRQoL) in older age have been cross-sectional analyzed only fat or lean mass. Hence, it is poorly known whether mass are independently associated with subsequent changes HRQoL. We investigated baseline HRQoL over a 10-year period adults.We studied 1044 men women from Helsinki Birth Cohort Study (age 57-70 years at baseline). Bioelectrical impedance analysis was used to derive index (FMI,...
BackgroundEarly growth, stress, and socioeconomic factors are associated with future risk of individual chronic diseases. It is uncertain whether they also affect the rate multimorbidity accumulation later in life. This study aimed to explore early life at which diseases accumulated across older age.MethodsIn this national birth cohort study, we studied people born Helsinki University Central Hospital, Helsinki, Finland between Jan 1, 1934, Dec 31, 1944, who attended child welfare clinics...
Hearing loss is a common health concern in older people, and the prevalence of hearing increases with aging. Poor may cause difficulties everyday life situations reduce quality (QoL). The aim this study was to assess associations between different domains QoL (physical, psychological, social, environmental), perceived various situations, audiometrically measured level among community-dwelling adults. Cross-sectional analysis 76- 91-year-old Data on (WHO Quality Life Assessment short version)...
Abstract A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural strength of tibia and radius are mainly regulated by same environmental factors, is more affected environment. Introduction: The habitual loading environment bone may modulate relative contribution factors to structure. purpose this study was estimate common site-specific interindividual variation in compressive weight-bearing non–weight-bearing radius. Materials Methods: pQCT scans...
Abstract Background Sleep is essential for normal and healthy living. Lack of good quality sleep affects physical, mental emotional functions. Currently, the treatments obesity-related disorders focus more on suppressing sleep-related symptoms pharmaceutically are often accompanied by side effects. Thus, there urgent need alternative ways to combat chronic disorders. This study will investigate underlying mechanisms effects exercise diet intervention disorders, role gut microbiota in...