A5051581078- Hippo pathway signaling and YAP/TAZ
- Muscle Physiology and Disorders
- Hereditary Neurological Disorders
- Cellular Mechanics and Interactions
- Lipid metabolism and biosynthesis
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- Pluripotent Stem Cells Research
- Genetics and Physical Performance
- Endoplasmic Reticulum Stress and Disease
- Sphingolipid Metabolism and Signaling
- MicroRNA in disease regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Kruppel-like factors research
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Connective Tissue Growth Factor Research
- Inflammasome and immune disorders
- CAR-T cell therapy research
Fundación Ciencia and Vida
2023-2025
Wellcome/MRC Institute of Metabolic Science
2024
Medical Research Council
2024
University of Cambridge
2024
Pontificia Universidad Católica de Chile
2017-2024
Fundación Chile
2021-2022
We investigated the potential involvement of miRNAs in developmental programming cardiovascular diseases (CVD) by maternal obesity. Serum were measured individuals from Helsinki Birth Cohort (with known body mass index), and a mouse model was used to determine causative effects obesity during pregnancy ischemia-reperfusion on offspring cardiac miRNA expression release. miR-15b-5p levels increased sera males born mothers with higher BMI hearts adult mice obese dams. In an ex-vivo perfused...
Sarcoglycanopathies are muscle dystrophies caused by mutations in the genes encoding sarcoglycans (α, β, γ, and δ) that can destabilize dystrophin-associated glycoprotein complex at sarcolemma, leaving fibers vulnerable to damage after contraction, followed inflammatory fibrotic responses resulting weakness atrophy. Two signaling pathways have been implicated fibrosis inflammation various tissues: autotaxin/lysophosphatidic acid (ATX-LPA) yes-associated protein 1/transcriptional co-activator...
Loss of motoneuron innervation (denervation) is a hallmark neurodegeneration and aging the skeletal muscle. Denervation induces fibrosis, response attributed to activation expansion resident fibro/adipogenic progenitors (FAPs), i.e., multipotent stromal cells with myofibroblast potential. Using in vivo silico approaches, we revealed FAPs as novel cell population that activates transcriptional coregulators YAP/TAZ muscle denervation. Here, found denervation expression activity whole lysates....