A5010247420- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Mitochondrial Function and Pathology
- Environmental Toxicology and Ecotoxicology
- Epigenetics and DNA Methylation
- Selenium in Biological Systems
- Trace Elements in Health
- Fish Ecology and Management Studies
- Energy and Environment Impacts
- Iron Metabolism and Disorders
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
- Reproductive biology and impacts on aquatic species
- Adipose Tissue and Metabolism
- Aquaculture Nutrition and Growth
- Mercury impact and mitigation studies
- Climate Change and Health Impacts
- Toxic Organic Pollutants Impact
- RNA modifications and cancer
- Infant Nutrition and Health
- Machine Learning in Healthcare
- Radiation Dose and Imaging
Columbia University
2019-2024
Centre Hospitalier Universitaire de Sherbrooke
2023
Creative Commons
2023
Université de Sherbrooke
2023
Columbia University Irving Medical Center
2018-2021
University of California, Riverside
2014-2017
Riverside
2017
Trace metal concentrations may affect cardiometabolic risk, but the role of prenatal exposure is unclear. We examined (1) relation between blood during pregnancy and child risk factors; (2) overall effects metals mixture (essential vs. nonessential); (3) interactions metals. measured 11 in maternal second-trimester whole a prospective birth cohort Mexico City. In children 4-6 years old, we body mass index (BMI), percent fat, pressure (N = 609); plasma hemoglobin A1C (HbA1c), non-high-density...
Human milk plays a critical role in infant development and health, particularly cognitive, immune, cardiometabolic functions. Milk contains extracellular vesicles (EVs) that can transport biologically relevant cargo from mother to infant, including microRNAs (miRNAs). We aimed characterize EV-miRNA profiles human population cohort, assess potential pathways ontology, investigate associations with maternal characteristics. conducted the first study describe EV miRNA profile of 364 mothers...
Phthalates are associated with several adverse health outcomes, but few studies have evaluated phthalate exposures in Mexican populations, particularly pregnant women. Between 2007 and 2011, 948 women from Mexico City were recruited as part of the PROGRESS cohort. We quantified 17 metabolites phthalates alternatives urine samples collected during second third trimesters examined temporal trends metabolite concentrations, within-person reproducibility, relations individual sociodemographic,...
Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases diabetes. DNA methylation is a sensitive biomarker of aging-related processes novel epigenetic-based "clocks" can be used to estimate accelerated biological aging that may underlie risk. Metals alter methylation, yet little known about their individual combined impact on epigenetic age acceleration. Our objective was investigate the associations metals several...
Temperature is a key variable affecting the timing of amphibian metamorphosis from tadpoles to tetrapods, through production and subsequent function thyroid hormones (TH). Thyroid can be impaired by environmental contaminants as well temperature. Tadpoles experience large temperature fluctuations in their habitats many species are distributed areas that may impacted agriculture. Diuron widely used herbicide detected freshwater ecosystems impact endocrine aquatic organisms. We evaluated...
Manganese (Mn) is an essential nutrient but also a toxicant at high exposures, when it can induce oxidative stress (OS). Mn uptake inversely correlated with iron status, therefore anemic individuals may be more susceptible to overload induced-OS, which manifest as changes in mitochondrial DNA copy number (mtDNA CN). Our objectives were to: 1) determine stage-specific associations of prenatal exposure cord blood MtDNA CN; and 2) investigate effect modification by maternal anemia, ferritin,...
Post-transcriptional modifications of RNA constitute fundamental mechanisms gene regulation. N6-methyladenosine (m6A) is critical for health and disease modulated by cellular stressors. However, associations between environmental exposures m6A have not been studied in humans. We aimed to examine tobacco smoking particulate air pollution with mRNA expression levels its reader, writer eraser (RWE) genes blood.Using the Beijing Truck Driver Air Pollution Study, we investigated global from...
Inorganic arsenic (As) may increase the risk of cardiovascular disease (CVD) and all-cause mortality through accelerated aging, which can be estimated using epigenetic-based measures.
Chronic lead exposure is associated with both subclinical and clinical cardiovascular disease. We evaluated whether declines in blood were changes systolic diastolic pressure adult American Indian participants from the SHFS (Strong Heart Family Study).
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a high-production volume organophosphate flame retardant widely used within the United States. Within zebrafish, initiation of TDCIPP exposure at 0.75 h post-fertilization (hpf) results in genome-wide alterations methylation during cleavage (2 hpf) as well epiboly delay or arrest (at higher concentrations) late-blastula and early-gastrula (4–6 hpf). To determine whether these TDCIPP-induced effects were associated with impacts on...
Phthalate exposure is ubiquitous and may affect biological pathways related to regulators of blood pressure. Given the profound changes in vasculature during pregnancy, pregnant women be particularly susceptible potential effects phthalates on We examined associations phthalate pregnancy with maternal pressure trajectories from mid-pregnancy through 72 months postpartum. Women singleton pregnancies delivering a live birth Mexico City were enrolled second trimester (n=892). Spot urine samples...
Background Lead is a cardiotoxic metal with variety of adverse health effects. In the absence data on bone lead exposure, epigenetic biomarkers can serve as indicators cumulative exposure and body burden. Herein, we leveraged novel to investigate their association cardiovascular disease (CVD) incidence mortality. Methods Results Blood DNA methylation was measured using Illumina MethylationEPIC BeadChip among 2231 participants Strong Heart Study (SHS) at baseline (1989–1991). Epigenetic...
Exposure to low moderate arsenic (As) levels has been associated with type 2 diabetes (T2D) and other chronic diseases in American Indian communities. Prenatal exposure As may also increase the risk for T2D adulthood, maternal adult offspring metabolic health measurements. We hypothesized that T2D-related outcomes born women exposed can be evaluated utilizing a maternally-derived molecular biosignature of exposure. Herein, we association DNA methylation incident insulin resistance...
Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is an organophosphate flame retardant that impacts zebrafish epiboly - effect may be associated with genome-wide hypomethylation. Using as a model, the objectives of this study were to (1) quantify concentration-dependent TDCIPP on epiboly; (2) determine whether co-exposure folic acid (FA) methyl donor mitigates TDCIPP-induced impacts; and (3) using ten previously identified TDCIPP-susceptible loci, rely bisulfite amplicon sequencing (BSAS)...
Prenatal phthalate exposures may affect processes that underlie offspring cardiometabolic health, but findings from studies examining these associations are conflicting. We examined between biomarkers of during pregnancy with child lipid and adipokine levels. Data were 463 mother-child pairs in the PROGRESS cohort Mexico City. quantified 15 metabolites 2nd 3rd trimester maternal urine samples created an average measure using geometric mean. evaluated as nine biomarkers, including four...
Early life exposures to marine contaminants can adversely impact child health but modes of action are unclear. Human milk contains extracellular vesicles (EVs) that transport biologically relevant cargo from mother infant, including microRNAs (miRNAs), and may partly mediate the effects pollutants on health. However, role miRNA expression in EVs is unexplored.