A5046741732- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Health, Environment, Cognitive Aging
- Diabetes Management and Education
- Endometrial and Cervical Cancer Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microtubule and mitosis dynamics
- Uterine Myomas and Treatments
- Cardiovascular Health and Risk Factors
- Cancer Genomics and Diagnostics
- Air Quality Monitoring and Forecasting
- Transcranial Magnetic Stimulation Studies
- Chronic Disease Management Strategies
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Heavy Metal Exposure and Toxicity
- Genetic factors in colorectal cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chromosomal and Genetic Variations
- Intraperitoneal and Appendiceal Malignancies
- Bladder and Urothelial Cancer Treatments
- Health disparities and outcomes
- Genomics and Chromatin Dynamics
Instituto Nacional de Cancerología
2014-2024
Universidad Nacional Autónoma de México
2014-2024
Icahn School of Medicine at Mount Sinai
2023-2024
Columbia University
2020-2023
Mount Sinai Hospital
2023
Harvard University
2015-2019
Centro Científico Tecnológico - Tucumán
2019
Environmental Health
2016
Çanakkale Onsekiz Mart Üniversitesi
2015
VA Boston Healthcare System
2015
Air particulate matter (PM) is a ubiquitous environmental exposure associated with oxidation, inflammation, and age-related chronic disease. Whether PM loss of bone mineral density (BMD) risk fractures undetermined.We conducted two complementary studies of: (i) long-term <2.5 μm (PM2.5) levels osteoporosis-related fracture hospital admissions among 9.2 million Medicare enrollees the Northeast/Mid-Atlantic United States between 2003-2010; (ii) black carbon [BC] PM2.5 levels, serum calcium...
Background— Exposure to black carbon (BC), a tracer of vehicular-traffic pollution, is associated with increased blood pressure (BP). Identifying biological factors that attenuate BC effects on BP can inform prevention. We evaluated the role mitochondrial abundance, an adaptive mechanism compensating for cellular-redox imbalance, in BC-BP relationship. Methods and Results— At ≥1 visits among 675 older men from Normative Aging Study (observations=1252), we assessed daily ambient levels...
Human milk plays a critical role in infant development and health, particularly cognitive, immune, cardiometabolic functions. Milk contains extracellular vesicles (EVs) that can transport biologically relevant cargo from mother to infant, including microRNAs (miRNAs). We aimed characterize EV-miRNA profiles human population cohort, assess potential pathways ontology, investigate associations with maternal characteristics. conducted the first study describe EV miRNA profile of 364 mothers...
The gut microbiome is important in modulating health childhood. Metal exposures affect multiple outcomes, but their ability to modify bacterial communities children poorly understood.
Abstract Background Although important achievements have been done in type 2 diabetes mellitus (T2D) treatment and glycemic control, new strategies may take advantage of non-pharmacological approaches other potential determinants health (e.g., socioeconomic status, education, knowledge, physical activity, self-care behavior). However, the relationships between these factors are not totally clear studied context large urban settings. This study aimed to explore relationship control (GC) a...
ABSTRACT Objective Psychosocial stressors have been linked with accelerated biological aging in adults; however, few studies examined across the life course relation to aging. Methods In 359 individuals (57% White, 34% Black) from Child Health and Development Studies Disparities study, economic (income, education, financial strain), social (parent-child relations, caretaker responsibilities) traumatic (death of a sibling or child, violence exposure) were assessed at multiple time points...
Theodore Boveri, eminent German pathologist, observed aneuploidy in cancer cells more than a century ago and suggested that derived from single progenitor cell acquires the potential for uncontrolled continuous proliferation. Currently, it is well known virtually all cancers. Gain loss of chromosomal material neoplastic considered to be process diversification leads survival fittest clones. According Darwin's theory evolution, environment determines grounds upon which selection takes place...
Background Short‐term fine particles ( PM 2.5 ) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility essential for intervention. We evaluated whether Toll‐like receptor 2 TLR methylation, reversible immune‐epigenetic process, and its dietary modulation by flavonoids methyl nutrients, modify to variability effects following exposure. Methods Results measured repeatedly...
Long-term air pollution exposure has been associated with age-related cognitive impairment, possibly because of enhanced inflammation. Leukocytes longer telomere length (TL) are more responsive to inflammatory stimuli, yet TL not evaluated in relation and cognition.We assessed whether modifies the association 1-year black carbon (BC), a marker traffic-related pollution, function older men, we examined this modification is independent age C-reactive protein (CRP), inflammation.Between 1999...
Abstract Background Although important advances in treatment strategies have been developed type 2 diabetes mellitus (T2DM), large gaps exist achieving glycemic control and preventing complications, particularly low-and middle-income countries, which suggests a potential effect of social determinants health (SDH, i.e., education level socioeconomic status). However, few studies determined the role SDH other (ODH, knowledge self-care scores) T2DM goals during effective multidisciplinary...
Abstract Background In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns covalent histone marks development. Until recently, microRNA (miRNA) was not well understood. particular, miR-125b1 suggested to be an miRNA tumor suppressor activity, it shown deregulated in various human cancers. the present study, we evaluated at CpG island proximal transcription start site cell lines as normal tissues...
Satellite sequences are an important part of the pericentromeric regions in mammalian genomes; they play a relevant role chromosome stability and DNA hypomethylation these has been reported ICF syndrome some cancers that closely associated with chromosomal abnormalities. Epigenetic modifications satellite their consequences have not extensively studied human cells. In present work, we evaluated 2 methylation patterns lymphocytes exposed to 5-azacytidine (5-azaC) assessed relationship between...
Early life exposures to marine contaminants can adversely impact child health but modes of action are unclear. Human milk contains extracellular vesicles (EVs) that transport biologically relevant cargo from mother infant, including microRNAs (miRNAs), and may partly mediate the effects pollutants on health. However, role miRNA expression in EVs is unexplored.
APOE is the biomarker with greatest known influence on cognitive function; however, effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations. We evaluated using multiplex PCR for genotyping Mini-Mental State Examination (MMSE) to evaluate function 819 individuals from VA Normative Aging Study. Combinatorial analysis all individual rs440446 did not show any association performance. Polymorphism was...