A5041000550- Neonatal and fetal brain pathology
- Phonetics and Phonology Research
- School Health and Nursing Education
- Health, psychology, and well-being
- Neonatal Respiratory Health Research
- Health, Medicine and Society
- Schizophrenia research and treatment
- Speech and Audio Processing
- Immune Response and Inflammation
- Hearing Loss and Rehabilitation
- Education, sociology, and vocational training
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- Social Sciences and Governance
- Traumatic Brain Injury and Neurovascular Disturbances
- Bipolar Disorder and Treatment
- Pregnancy and Medication Impact
- Community Health and Development
- French Urban and Social Studies
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
Université de Montréal
1991-2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Sherbrooke
2005-2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2021
Centre Hospitalier Universitaire de Sherbrooke
2007-2017
Health and Social Services Centre University Institute of Geriatrics of Sherbrooke
2014
Institute of Health Services and Policy Research
2013
Institute of Population and Public Health
2013
Université du Québec à Montréal
2006-2010
Institut National de la Recherche Scientifique
2010
Objective The objective was to compare, in a real‐world setting, the risk of mental and physical health events associated with different antipsychotic drugs (clozapine, olanzapine, risperidone, quetiapine first‐generation antipsychotics) patients SZ . Methods This is retrospective cohort study using administrative data. Outcome measures included any event (suicide, hospitalization or emergency visit for disorders) (death other than suicide, disorders). Cox proportional hazard models were...
The gut microbiome is important in modulating health childhood. Metal exposures affect multiple outcomes, but their ability to modify bacterial communities children poorly understood.
We developed an original rat model for neonatal brain lesions whereby we explored the sequential effects of infectious and hypoxic-ischemic aggressions. investigated influence combined exposure to <i>prenatal</i> infection with insult. Infectious effect was produced by administrating lipopolysaccharide (LPS) intraperitoneally pregnant rats starting on embryonic day 17. Hypoxia-ischemia (H/I) induced in pups at postnatal 1 (P1) ligature right common carotid artery followed hypoxia...
In animals, decades of research have shown that serotonin (5-HT) is involved in endogenous pain inhibition systems, which are deficient chronic disorders such as fibromyalgia (FM). humans, there preliminary evidence showing 5-HT the FM pathophysiology. current endophenotyping study, we sought to investigate, for first time relationships between transporter promoter region (5-HTTLPR) polymorphism and experimentally-induced perception/inhibition healthy controls (HC) patients.Participants were...
Adequate animal glioma models are mandatory for the pursuit of preclinical research in neuro-oncology. Many implantation have been described, but none perfectly emulate human malignant gliomas. This work reports our experience standardizing, optimizing and characterizing Fischer/F98 model on clinical, pathological, radiological metabolic aspects.F98 cells were implanted 70 Fischer rats, varying quantity volume solution, using a micro-infusion pump to minimize trauma, after adequate...
Using a model of perinatal brain lesions induced by lipopolysaccharide and hypoxia/ischemia, we hypothesized that interleukin-2 (IL-2), neurotoxic cytokine, was enhanced within injured brains. We showed hypoxia/ischemia both intracerebral IL-2 mRNA protein levels, with maximum increase upon hypoxia/ischemia. The lack detectable T lymphocytes suggested the synthesis neural cells. Lipopolysaccharide hypoxia triggered cultured microglia peak after exposure to hypoxia. Double-labeling showed, in...
Abstract Most antipsychotic (AP) drugs are dopamine (DA) D2 receptor (DRD2) antagonists and remain the main pharmacological treatment of schizophrenia. Long‐term AP use can give rise to tardive dyskinesia. It has been reported that chronic with APs induces DRD2 upregulation oxidative stress, which have associated We showed previously H 2 O ‐induced stress increased expression in human SH‐SY5Y neuroblastoma cells. report here effects on levels same cell line inhibition phenomena by...
Ten normally hearing and 10 age-matched subjects with moderate-to-severe impairment were recorded producing a protocol of 18 basic syllables [/pi/,/pa/,/pu/;/bi/,/ba/,/bu/; /ti/,/ta/,/tu/ ;/di/,/da/,/du/; /ki/,/ka/,/ku/; /gi/,/ga/,/gu/] repeated five times. The resulting 90 digitized measured for (a) total duration; (b) voice-onset time (VOT) the initial consonant; (c) fundamental frequency (F0) at midpoint vowel; (d) formant frequencies (F1, F2, F3), also vowel. Statistical comparisons...
Abstract Abnormalities of striatal dopaminergic neurotransmission play a significant role in the pathophysiology central nervous system disorders such as movement disorders, addictions and schizophrenia. The striatum appears to be exposed intrinsically high levels oxidative stress (OS). Little is known, however, on effect OS regulation dopamine D2 receptor (DRD2), key component neurotransmission. We report here effects H 2 O (a canonical oxidant non conventional messenger)...
There are numerous hurdles down the road for successfully scaling up health promotion innovations into formal programmes. The challenges of scaling-up process have mainly been conceived in terms available resources and technical or management problems. However, aiming greater impact sustainability involves addressing new contexts often adding actors whose perspectives may challenge established orientations. social dimension is thus critical. Building on existing conceptualizations...
Acoustic measures of (1) syllable duration, (2) voice onset time, (3) fundamental frequency (F0) and (4) the first three formant frequencies (F1, F2, F3) vowels were provided for a speech corpus produced by 10 French-speaking children (five boys, five girls, with an average age 9;4 years) profound hearing impairment (i.e. pure tone averages more than 100 dB HL.) These data then compared previously published moderate-to-severe 60 HL) normally children. The loss significantly different in all...
The small number of studies examining the association prenatal acetaminophen with birth outcomes have all relied on maternal self-report. It remains unknown whether exposure measured in a biological specimen is associated outcomes. To investigate meconium birthweight, gestational age, preterm birth, size for diabetes, preeclampsia, and high blood pressure. This cohort from Sherbrooke, QC, Canada, included 773 live births. Mothers no thyroid disease enrolled at their first care visit or...
Une recension des écrits sur la gestion de marginalité urbaine montre que depuis les années 1990, on assiste à changements importants le plan gouvernance dans l’espace public plusieurs villes du monde, plus en pensée termes sécuritaires et écosanitaires. À l’égard personnes marginalisées se dessine une intervention répressive qui contribue leur judiciarisation. Dans cet article, nous traitons effets d’une telle processus sortie rue jeunes partir résultats enquête terrain menée cadre...